(46 nodes) RHO GTPases Activate WASPs and WAVEs, and Actin, conserved site network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CBG23593	Protein CBG23593. (439 aa)
	arx-4	Protein CBR-ARX-4. (539 aa)
	CBG24443	Protein CBG24443. (93 aa)
	CBG24444	Protein CBG24444. (376 aa)
	CBG24445	Protein CBG24445. (368 aa)
	gex-2	Protein CBR-GEX-2. (1278 aa)
	CBG01565	Protein CBG01565. (188 aa)
	wsp-1	Protein CBR-WSP-1. (785 aa)
	CBG02160	Protein CBG02160. (395 aa)
	CBG02162	Protein CBG02162. (372 aa)
	CBG02163	Protein CBG02163. (93 aa)
	CBG02167	Protein CBG02167. (372 aa)
	gex-3	Protein CBR-GEX-3. (1140 aa)
	arx-7	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (152 aa)
	unc-60	Protein CBR-UNC-60; Belongs to the actin-binding proteins ADF family. (293 aa)
	pfn-3	Profilin; Belongs to the profilin family. (114 aa)
	abi-1	Protein CBR-ABI-1. (487 aa)
	CBG10797	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (215 aa)
	CBG11865	Protein CBG11865. (350 aa)
	hum-1	Protein CBR-HUM-1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1131 aa)
	CBG13967	Protein CBG13967. (367 aa)
	plst-1	Protein CBR-PLST-1. (623 aa)
	unc-78	Protein CBR-UNC-78. (611 aa)
	CBG14863	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa)
	arx-5	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa)
	CBG16073	Protein CBG16073. (502 aa)
	toca-1	Protein CBR-TOCA-1. (588 aa)
	twf-2	Protein CBG16364. (376 aa)
	cas-1	Adenylyl cyclase-associated protein; Belongs to the CAP family. (1230 aa)
	wip-1	Protein CBR-WIP-1. (313 aa)
	viro-2	Protein CBG16600. (552 aa)
	act-5	Protein CBR-ACT-5. (375 aa)
	dbn-1	Protein CBG18266. (672 aa)
	toca-2	Protein CBR-TOCA-2. (677 aa)
	arx-6	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (169 aa)
	arx-3	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (382 aa)
	wve-1	Protein CBR-WVE-1. (475 aa)
	gsnl-1	Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. (474 aa)
	CBG22322	Protein CBG22322. (372 aa)
	aipl-1	Protein CBR-TAG-216. (599 aa)
	act-2	Protein CBR-ACT-2. (376 aa)
	act-4	Protein CBG23090. (376 aa)
	CBG26242	Protein CBG26242. (46 aa)
	CBG29119	Protein CBG29119. (274 aa)
	arx-2	Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (393 aa)
	arx-1	Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (426 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG01565	CBG02160	A8WRD1	A8WS31	Protein CBG01565.	Protein CBG02160.	0.491
CBG01565	CBG02162	A8WRD1	A8WS33	Protein CBG01565.	Protein CBG02162.	0.491
CBG01565	CBG02167	A8WRD1	A8WS37	Protein CBG01565.	Protein CBG02167.	0.491
CBG01565	CBG10797	A8WRD1	A8XBT7	Protein CBG01565.	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.	0.738
CBG01565	CBG13967	A8WRD1	A8XIX7	Protein CBG01565.	Protein CBG13967.	0.596
CBG01565	CBG14863	A8WRD1	A8XKV2	Protein CBG01565.	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.774
CBG01565	CBG22322	A8WRD1	A8Y226	Protein CBG01565.	Protein CBG22322.	0.491
CBG01565	CBG23593	A8WRD1	A8WIW5	Protein CBG01565.	Protein CBG23593.	0.916
CBG01565	CBG24443	A8WRD1	A8WKQ4	Protein CBG01565.	Protein CBG24443.	0.491
CBG01565	CBG24444	A8WRD1	A8WKQ5	Protein CBG01565.	Protein CBG24444.	0.491
CBG01565	CBG24445	A8WRD1	A8WKQ6	Protein CBG01565.	Protein CBG24445.	0.491
CBG01565	CBG26242	A8WRD1	B6ILW3	Protein CBG01565.	Protein CBG26242.	0.593
CBG01565	CBG29119	A8WRD1	H8WHC9	Protein CBG01565.	Protein CBG29119.	0.491
CBG01565	abi-1	A8WRD1	A8X822	Protein CBG01565.	Protein CBR-ABI-1.	0.766
CBG01565	act-2	A8WRD1	A8Y4Q9	Protein CBG01565.	Protein CBR-ACT-2.	0.491
CBG01565	act-4	A8WRD1	A8Y4R0	Protein CBG01565.	Protein CBG23090.	0.491
CBG01565	act-5	A8WRD1	A8XS95	Protein CBG01565.	Protein CBR-ACT-5.	0.609
CBG01565	arx-1	A8WRD1	Q61WW9	Protein CBG01565.	Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).	0.903
CBG01565	arx-2	A8WRD1	Q61JZ2	Protein CBG01565.	Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).	0.927
CBG01565	arx-3	A8WRD1	A8XT67	Protein CBG01565.	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.875