(72 nodes) Mixed, incl. MTOR signalling, and TOR signaling network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Cbr-srx-120	Protein CBR-SRX-120. (649 aa)
	CBG24789	Protein CBG24789. (740 aa)
	CBG24891	Protein CBG24891. (259 aa)
	CBG25088	Protein CBG25088. (245 aa)
	CBG00206	Protein CBG00206; Belongs to the protein kinase superfamily. (350 aa)
	mop-25.2	Protein CBR-MOP-25.2. (338 aa)
	aakg-5	Protein CBR-AAKG-5. (476 aa)
	nprl-3	Protein CBG01588. (490 aa)
	aakg-3	Protein CBR-AAKG-3. (398 aa)
	aakg-4	Protein CBR-AAKG-4. (461 aa)
	ilkp-1	Protein CBG02976. (241 aa)
	raga-1	Protein CBR-RAGA-1. (312 aa)
	CBG02786	Protein CBG02786. (805 aa)
	rict-1	Protein CBG02784. (830 aa)
	npp-18	Nucleoporin SEH1; Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus; Belongs to the WD repeat SEC13 family. (366 aa)
	sesn-1	Protein CBG03915. (557 aa)
	mlst-8	Protein CBG03961. (343 aa)
	CBG05170	Protein CBG05170. (4154 aa)
	pha-4	Protein CBR-PHA-4. (477 aa)
	par-4	Serine/threonine-protein kinase par-4; Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Phosphorylates and restricts the asymmetry effectors mex-5 and mex-6 to the anterior cytoplasm of the zygote and maintains these phosphorylations until fertilization. Phosphorylates and regulates aak-2 in response to oxidative stress. May also play a role in motility, behavioral response, regulation of lifespan and dauer formation through this pathway (By similarity). (649 aa)
	slr-2	Protein CBG05648. (384 aa)
	CBG05662	Protein CBG05662. (197 aa)
	ragc-1	Protein CBR-RAGC-1. (338 aa)
	CBG05980	Protein CBG05980. (613 aa)
	nprl-2	Protein CBG05911. (756 aa)
	aak-1	Non-specific serine/threonine protein kinase. (609 aa)
	CBG07019	Protein CBG07019. (346 aa)
	aakb-1	Protein CBR-AAKB-1. (268 aa)
	pdk-1	Protein CBR-PDK-1. (644 aa)
	CBG08151	Protein CBG08151; Belongs to the protein kinase superfamily. (401 aa)
	mop-25.3	MO25-like protein 3; Belongs to the Mo25 family. (492 aa)
	ppm-1.a	Protein CBR-PPM-1. (468 aa)
	akt-1	Non-specific serine/threonine protein kinase. (605 aa)
	CBG09543	Protein CBG09543. (121 aa)
	rheb-1	GTP-binding protein Rheb homolog 1; Binds GTP and exhibits intrinsic GTPase activity. Belongs to the small GTPase superfamily. Rheb family. (206 aa)
	CBG10328	Tyrosine-protein kinase. (417 aa)
	CBG10201	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (370 aa)
	flcn-1	Protein CBG11189. (305 aa)
	CBG11190	Protein CBG11190. (346 aa)
	lmtr-2	Protein CBG11395. (124 aa)
	aakg-1	Protein CBG11682. (519 aa)
	let-363	Serine/threonine-protein kinase TOR. (1721 aa)
	rsks-1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (540 aa)
	aakb-2	Protein CBR-AAKB-2. (273 aa)
	immp-1	Protein CBR-IMMP-1. (156 aa)
	CBG13453	Protein CBG13453. (146 aa)
	CBG13871	Protein CBG13871. (1063 aa)
	mop-25.1	Protein CBR-MOP-25.1. (615 aa)
	CBG14553	Protein CBG14553. (5515 aa)
	CBG15618	Protein CBG15618. (460 aa)
	CBG15660	Protein CBG15660; Belongs to the protein kinase superfamily. (299 aa)
	CBG15853	Protein CBG15853. (281 aa)
	sgk-1	Serine/threonine-protein kinase sgk-1; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating development, stress response, and longevity. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their function. Acts downstream of rict-1 to regulate fat storage, size, and development. Downstream of age-1 and together with akt-1/2, promotes cell survival during embryonic development. Does not appear to play [...] (464 aa)
	CBG16302	Non-specific serine/threonine protein kinase. (564 aa)
	CBG16284	Protein CBG16284; Belongs to the protein kinase superfamily. (442 aa)
	aakg-2	Protein CBR-AAKG-2. (425 aa)
	aak-2	Non-specific serine/threonine protein kinase. (641 aa)
	CBG16239	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa)
	strd-1	Protein CBR-STRD-1. (385 aa)
	CBG18395	Protein CBG18395; Belongs to the protein kinase superfamily. (380 aa)
	CBG20115	Protein CBG20115. (361 aa)
	CBG20695	Protein CBG20695. (93 aa)
	sinh-1	Protein CBR-SINH-1. (638 aa)
	efk-1	Protein CBR-EFK-1. (772 aa)
	CBG21229	Protein CBG21229. (1384 aa)
	CBG21773	Protein CBG21773. (459 aa)
	daf-15	Protein CBR-DAF-15. (1795 aa)
	CBG23277	Protein CBG23277. (3553 aa)
	lmtr-3	Protein CBG23109. (147 aa)
	CBG18724	Protein CBG18724. (3212 aa)
	CBG25377	Protein CBG25377; Belongs to the PI3/PI4-kinase family. (916 aa)
	CBG27023	Protein CBG27023. (101 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG00206	CBG02786	A8WMH0	A8WTI5	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBG02786.	0.951
CBG00206	CBG05980	A8WMH0	A8X168	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBG05980.	0.454
CBG00206	CBG08151	A8WMH0	A8X5X8	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBG08151; Belongs to the protein kinase superfamily.	0.581
CBG00206	CBG10201	A8WMH0	A8XAV3	Protein CBG00206; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.571
CBG00206	CBG13453	A8WMH0	A8XHQ7	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBG13453.	0.469
CBG00206	CBG15618	A8WMH0	A8XME2	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBG15618.	0.736
CBG00206	CBG15660	A8WMH0	A8XMH2	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBG15660; Belongs to the protein kinase superfamily.	0.778
CBG00206	CBG15853	A8WMH0	A8XMW0	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBG15853.	0.444
CBG00206	CBG16239	A8WMH0	A8XNU4	Protein CBG00206; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.567
CBG00206	CBG16284	A8WMH0	A8XNR1	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBG16284; Belongs to the protein kinase superfamily.	0.541
CBG00206	CBG16302	A8WMH0	A8XNQ5	Protein CBG00206; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.566
CBG00206	CBG18395	A8WMH0	A8XSL9	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBG18395; Belongs to the protein kinase superfamily.	0.535
CBG00206	CBG20695	A8WMH0	A8XYE3	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBG20695.	0.483
CBG00206	CBG24789	A8WMH0	A8WLH8	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBG24789.	0.598
CBG00206	CBG25088	A8WMH0	A8WM31	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBG25088.	0.469
CBG00206	CBG25377	A8WMH0	B6IIP1	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBG25377; Belongs to the PI3/PI4-kinase family.	0.592
CBG00206	Cbr-srx-120	A8WMH0	A8WK94	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBR-SRX-120.	0.542
CBG00206	aak-1	A8WMH0	A8X3C9	Protein CBG00206; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.552
CBG00206	aak-2	A8WMH0	A8XNT5	Protein CBG00206; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.526
CBG00206	daf-15	A8WMH0	A8Y0U3	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBR-DAF-15.	0.727