(13 nodes) Nucleotide-activated protein kinase complex, and Mo25-like network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mop-25.2	Protein CBR-MOP-25.2. (338 aa)
	aakg-5	Protein CBR-AAKG-5. (476 aa)
	aakg-3	Protein CBR-AAKG-3. (398 aa)
	aakg-4	Protein CBR-AAKG-4. (461 aa)
	par-4	Serine/threonine-protein kinase par-4; Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Phosphorylates and restricts the asymmetry effectors mex-5 and mex-6 to the anterior cytoplasm of the zygote and maintains these phosphorylations until fertilization. Phosphorylates and regulates aak-2 in response to oxidative stress. May also play a role in motility, behavioral response, regulation of lifespan and dauer formation through this pathway (By similarity). (649 aa)
	aak-1	Non-specific serine/threonine protein kinase. (609 aa)
	aakb-1	Protein CBR-AAKB-1. (268 aa)
	aakg-1	Protein CBG11682. (519 aa)
	aakb-2	Protein CBR-AAKB-2. (273 aa)
	mop-25.1	Protein CBR-MOP-25.1. (615 aa)
	aakg-2	Protein CBR-AAKG-2. (425 aa)
	aak-2	Non-specific serine/threonine protein kinase. (641 aa)
	strd-1	Protein CBR-STRD-1. (385 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
aak-1	aak-2	A8X3C9	A8XNT5	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.988
aak-1	aakb-1	A8X3C9	A8X4W7	Non-specific serine/threonine protein kinase.	Protein CBR-AAKB-1.	0.985
aak-1	aakb-2	A8X3C9	A8XHB4	Non-specific serine/threonine protein kinase.	Protein CBR-AAKB-2.	0.984
aak-1	aakg-1	A8X3C9	A8XDZ3	Non-specific serine/threonine protein kinase.	Protein CBG11682.	0.996
aak-1	aakg-2	A8X3C9	A8XNS7	Non-specific serine/threonine protein kinase.	Protein CBR-AAKG-2.	0.574
aak-1	aakg-3	A8X3C9	A8WRT4	Non-specific serine/threonine protein kinase.	Protein CBR-AAKG-3.	0.485
aak-1	aakg-4	A8X3C9	A8WS19	Non-specific serine/threonine protein kinase.	Protein CBR-AAKG-4.	0.500
aak-1	aakg-5	A8X3C9	A8WP59	Non-specific serine/threonine protein kinase.	Protein CBR-AAKG-5.	0.948
aak-1	mop-25.1	A8X3C9	A8XJS2	Non-specific serine/threonine protein kinase.	Protein CBR-MOP-25.1.	0.947
aak-1	mop-25.2	A8X3C9	A8WP05	Non-specific serine/threonine protein kinase.	Protein CBR-MOP-25.2.	0.947
aak-1	par-4	A8X3C9	A8X0C4	Non-specific serine/threonine protein kinase.	Serine/threonine-protein kinase par-4; Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Phosphorylates and restricts the asymmetry effectors mex-5 and mex-6 to the anterior cytoplasm of the zygote and maintains these phosphorylations until fertilization. Phosphorylates and regulates aak-2 in response to oxidative stress. May also play a role in motility, behavioral response, regulation of lifespan and dauer formation through this pathway (By similarity).	0.967
aak-1	strd-1	A8X3C9	A8XSB0	Non-specific serine/threonine protein kinase.	Protein CBR-STRD-1.	0.954
aak-2	aak-1	A8XNT5	A8X3C9	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.988
aak-2	aakb-1	A8XNT5	A8X4W7	Non-specific serine/threonine protein kinase.	Protein CBR-AAKB-1.	0.995
aak-2	aakb-2	A8XNT5	A8XHB4	Non-specific serine/threonine protein kinase.	Protein CBR-AAKB-2.	0.995
aak-2	aakg-1	A8XNT5	A8XDZ3	Non-specific serine/threonine protein kinase.	Protein CBG11682.	0.997
aak-2	aakg-2	A8XNT5	A8XNS7	Non-specific serine/threonine protein kinase.	Protein CBR-AAKG-2.	0.773
aak-2	aakg-3	A8XNT5	A8WRT4	Non-specific serine/threonine protein kinase.	Protein CBR-AAKG-3.	0.603
aak-2	aakg-4	A8XNT5	A8WS19	Non-specific serine/threonine protein kinase.	Protein CBR-AAKG-4.	0.834
aak-2	aakg-5	A8XNT5	A8WP59	Non-specific serine/threonine protein kinase.	Protein CBR-AAKG-5.	0.984