STRINGSTRING
div-1 div-1 orc-2 orc-2 tim-1 tim-1 mcm-4 mcm-4 psf-3 psf-3 CBG06130 CBG06130 pri-2 pri-2 evl-18 evl-18 pri-1 pri-1 CBG10068 CBG10068 mcm-3 mcm-3 cdc-6 cdc-6 mcm-5 mcm-5 rpa-4 rpa-4 sld-5 sld-5 pola-1 pola-1 mcm-10 mcm-10 cdt-1 cdt-1 orc-5 orc-5 orc-1 orc-1 orc-4 orc-4 mcm-2 mcm-2 CBG18914 CBG18914 pole-2 pole-2 CBG19681 CBG19681 psf-2 psf-2 pole-1 pole-1 pole-4 pole-4 mcm-7 mcm-7 CBG23450 CBG23450 CBG23360 CBG23360 ctf-4 ctf-4 mcm-6 mcm-6 tipn-1 tipn-1 psf-1 psf-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
div-1DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (584 aa)
orc-2Protein CBR-ORC-2. (544 aa)
tim-1Protein CBR-TIM-1. (1404 aa)
mcm-4DNA helicase; Belongs to the MCM family. (830 aa)
psf-3Protein CBG05113. (193 aa)
CBG06130Protein CBG06130. (450 aa)
pri-2DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (512 aa)
evl-18Protein CBG09214. (997 aa)
pri-1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (411 aa)
CBG10068Protein CBG10068. (363 aa)
mcm-3Protein CBR-MCM-3; Belongs to the MCM family. (812 aa)
cdc-6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (531 aa)
mcm-5DNA helicase; Belongs to the MCM family. (771 aa)
rpa-4Protein CBR-RPA-4. (304 aa)
sld-5DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (219 aa)
pola-1DNA polymerase. (1473 aa)
mcm-10Protein CBG13203. (659 aa)
cdt-1Protein CBR-CDT-1. (658 aa)
orc-5Protein CBR-ORC-5. (398 aa)
orc-1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (651 aa)
orc-4Protein CBR-ORC-4. (384 aa)
mcm-2DNA helicase; Belongs to the MCM family. (892 aa)
CBG18914Protein CBG18914. (257 aa)
pole-2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
CBG19681Protein CBG19681. (142 aa)
psf-2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (226 aa)
pole-1DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2133 aa)
pole-4Protein CBG20898. (200 aa)
mcm-7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (729 aa)
CBG23450Protein CBG23450. (382 aa)
CBG23360DNA polymerase. (1081 aa)
ctf-4Protein CBG23065. (1105 aa)
mcm-6DNA replication licensing factor mcm-6; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentia [...] (810 aa)
tipn-1Protein TIPIN homolog; Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. Belongs to the CSM3 family. (239 aa)
psf-1Probable DNA replication complex GINS protein PSF1; The GINS complex plays an essential role in the initiation of DNA replication. (201 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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