STRINGSTRING
cand-1 cand-1 lin-23 lin-23 lrr-1 lrr-1 skr-1 skr-1 skr-20 skr-20 skr-19 skr-19 skr-21 skr-21 skr-16 skr-16 CBG09125 CBG09125 cul-5 cul-5 elc-1 elc-1 CBG11949 CBG11949 rbx-2 rbx-2 ned-8 ned-8 elb-1 elb-1 rfl-1 rfl-1 CBG17039 CBG17039 CBG17038 CBG17038 CBG17150 CBG17150 vhl-1 vhl-1 cul-2 cul-2 cul-1 cul-1 ula-1 ula-1 ubc-12 ubc-12 rbx-1 rbx-1 CBG22545 CBG22545 CBG27741 CBG27741 CBG19761 CBG19761 dcn-1 dcn-1 sel-10 sel-10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cand-1Protein CBR-CAND-1. (1124 aa)
lin-23Protein CBR-LIN-23. (682 aa)
lrr-1Protein CBR-LRR-1. (454 aa)
skr-1Protein CBR-SKR-1; Belongs to the SKP1 family. (172 aa)
skr-20Protein CBR-SKR-20; Belongs to the SKP1 family. (165 aa)
skr-19Protein CBR-SKR-19; Belongs to the SKP1 family. (162 aa)
skr-21Protein CBR-SKR-21; Belongs to the SKP1 family. (166 aa)
skr-16Protein CBR-SKR-16; Belongs to the SKP1 family. (181 aa)
CBG09125Protein CBG09125; Belongs to the SKP1 family. (197 aa)
cul-5Protein CBR-CUL-5; Belongs to the cullin family. (766 aa)
elc-1Protein CBR-ELC-1; Belongs to the SKP1 family. (123 aa)
CBG11949Protein CBG11949; Belongs to the ubiquitin-conjugating enzyme family. (171 aa)
rbx-2Protein CBR-RBX-2. (115 aa)
ned-8Protein CBR-NED-8. (76 aa)
elb-1Protein CBR-ELB-1. (117 aa)
rfl-1Protein CBR-RFL-1. (430 aa)
CBG17039Protein CBG17039; Belongs to the cullin family. (719 aa)
CBG17038Protein CBG17038; Belongs to the cullin family. (771 aa)
CBG17150Protein CBG17150. (659 aa)
vhl-1Protein CBR-VHL-1. (170 aa)
cul-2Protein CBR-CUL-2; Belongs to the cullin family. (850 aa)
cul-1Protein CBR-CUL-1; Belongs to the cullin family. (768 aa)
ula-1NEDD8-activating enzyme E1 regulatory subunit. (550 aa)
ubc-12Protein CBR-UBC-12; Belongs to the ubiquitin-conjugating enzyme family. (180 aa)
rbx-1Protein CBR-RBX-1. (110 aa)
CBG22545Protein CBG22545. (478 aa)
CBG27741Protein CBG27741; Belongs to the cullin family. (134 aa)
CBG19761Protein CBG19761. (250 aa)
dcn-1Defective in cullin neddylation protein 1; Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with rbx-1 to recruit the Nedd8-charged E2 enzyme to the cullin component of SCF-type complexes (By similarity). (367 aa)
sel-10F-box/WD repeat-containing protein sel-10; Probable substrate recognition component of SCF (SKP1-CUL-F- box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates synapse elimination in early development in the motor neuron HSNL. Cell autonomous negative regulator of lin-12/Notch- mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis. May target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation. Involved in sex determi [...] (589 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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