(72 nodes) SNARE binding, and Norepinephrine Neurotransmitter Release Cycle network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	snt-6	Protein CBR-SNT-6. (465 aa)
	CBG25086	Protein CBG25086. (423 aa)
	mltn-8	Protein CBG01376. (814 aa)
	CBG01377	Protein CBG01377. (1582 aa)
	uso-1	Protein CBG01765. (952 aa)
	sph-1	Protein CBR-SPH-1. (226 aa)
	CBG03275	Protein CBG03275. (124 aa)
	CBG03274	Protein CBG03274. (339 aa)
	rab-3	Protein CBR-RAB-3. (219 aa)
	syx-16	Protein CBR-SYN-16. (327 aa)
	unc-64	Syntaxin-1A; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent s [...] (293 aa)
	syd-2	Protein CBR-SYD-2. (1152 aa)
	cpx-2	Protein CBR-CPX-2. (145 aa)
	CBG05584	Protein CBG05584. (299 aa)
	CBG05923	Protein CBG05923. (1233 aa)
	cla-1	Protein CBR-TAG-199. (2352 aa)
	CBG05921	Protein CBG05921. (299 aa)
	snt-5	Protein CBR-SNT-5. (457 aa)
	CBG06423	Protein CBG06423. (254 aa)
	snap-29	Protein CBR-SNAP-29. (277 aa)
	snt-7	Protein CBR-SNT-7. (414 aa)
	syx-2	Protein CBR-SYX-2; Belongs to the syntaxin family. (295 aa)
	CBG08069	Protein CBG08069. (714 aa)
	sec-22	Protein CBR-SEC-22; Belongs to the synaptobrevin family. (214 aa)
	smgl-1	Protein CBR-SMGL-1. (1627 aa)
	CBG08254	Protein CBG08254. (335 aa)
	snn-1	Protein CBR-SNN-1. (448 aa)
	CBG08497	Protein CBG08497. (339 aa)
	syx-4	Protein CBR-SYX-4; Belongs to the syntaxin family. (293 aa)
	ric-4	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (235 aa)
	sri-18	Protein CBR-SRI-18. (208 aa)
	memb-2	Protein CBR-MEMB-2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (216 aa)
	use-1	Protein CBR-USE-1. (247 aa)
	unc-10	Protein CBR-UNC-10. (1636 aa)
	mltn-9	Protein CBR-MLTN-9. (744 aa)
	CBG11078	Protein CBG11078. (39 aa)
	snt-1	Protein CBR-SNT-1. (443 aa)
	snap-1	Protein CBR-SNAP-1. (470 aa)
	sue-1	Protein CBR-SUE-1. (539 aa)
	unc-13	Protein CBR-UNC-13. (2250 aa)
	Cbr-unc-13	Protein CBG11945. (394 aa)
	syx-7	Protein CBR-SYX-7; Belongs to the syntaxin family. (244 aa)
	syx-17	Protein CBR-SYX-17. (265 aa)
	rskn-1	Ribosomal protein S6 kinase. (803 aa)
	CBG13544	Protein CBG13544; Belongs to the STXBP/unc-18/SEC1 family. (575 aa)
	aex-4	Protein CBR-AEX-4. (209 aa)
	syx-3	Protein CBR-SYX-3; Belongs to the syntaxin family. (305 aa)
	cat-1	Protein CBR-CAT-1. (554 aa)
	tom-1	Protein CBR-TOM-1. (1101 aa)
	CBG15059	Protein CBG15059. (117 aa)
	snt-2	Protein CBR-SNT-2. (370 aa)
	rimb-1	Protein CBR-TAG-168. (1337 aa)
	gos-28	Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. Cooperates with ykt-6 for proper expression of Golgi-resident proteins. Required along with ykt-6 for normal embryonic development, seam cell division or differentiation, and ray formation (By similarity). (234 aa)
	ykt-6	Protein CBR-YKT-6; Belongs to the synaptobrevin family. (201 aa)
	memb-1	Golgi SNAP receptor complex member 2 homolog memb-1; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (212 aa)
	Cbr-snb-7	Protein CBR-SNB-7. (101 aa)
	unc-18	Protein CBR-UNC-18; Belongs to the STXBP/unc-18/SEC1 family. (590 aa)
	CBG17418	Protein CBG17418. (2818 aa)
	sly-1	Protein CBG18370; Belongs to the STXBP/unc-18/SEC1 family. (720 aa)
	syx-18	Protein CBR-SYX-18. (421 aa)
	nsf-1	Protein CBR-NSF-1. (754 aa)
	nbet-1	Protein CBR-NBET-1. (106 aa)
	CBG21068	Protein CBG21068. (462 aa)
	vti-1	Protein CBR-VTI-1. (221 aa)
	vamp-8	Protein CBG22395. (113 aa)
	snb-2	Protein CBR-SNB-2. (114 aa)
	rskd-1	Protein CBR-RSKD-1. (850 aa)
	syx-5	Protein CBR-SYX-5; Belongs to the syntaxin family. (378 aa)
	CBG25344	Protein CBG25344. (78 aa)
	CBG27733	Protein CBG27733. (67 aa)
	cpx-1	Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family. (143 aa)
	snb-1	Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function (By similarity). (108 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG01377	CBG08254	A8WQ97	A8X655	Protein CBG01377.	Protein CBG08254.	0.479
CBG01377	CBG13544	A8WQ97	A8XI54	Protein CBG01377.	Protein CBG13544; Belongs to the STXBP/unc-18/SEC1 family.	0.688
CBG01377	CBG15059	A8WQ97	A8XLA9	Protein CBG01377.	Protein CBG15059.	0.524
CBG01377	CBG17418	A8WQ97	A8XR05	Protein CBG01377.	Protein CBG17418.	0.777
CBG01377	Cbr-snb-7	A8WQ97	A8XP96	Protein CBG01377.	Protein CBR-SNB-7.	0.606
CBG01377	Cbr-unc-13	A8WQ97	A8XEN0	Protein CBG01377.	Protein CBG11945.	0.487
CBG01377	aex-4	A8WQ97	A8XJN5	Protein CBG01377.	Protein CBR-AEX-4.	0.610
CBG01377	cpx-1	A8WQ97	Q60PP8	Protein CBG01377.	Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family.	0.439
CBG01377	cpx-2	A8WQ97	A8WZF1	Protein CBG01377.	Protein CBR-CPX-2.	0.439
CBG01377	memb-1	A8WQ97	A8XP14	Protein CBG01377.	Golgi SNAP receptor complex member 2 homolog memb-1; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.	0.469
CBG01377	memb-2	A8WQ97	A8X9A4	Protein CBG01377.	Protein CBR-MEMB-2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.	0.469
CBG01377	nbet-1	A8WQ97	A8XX36	Protein CBG01377.	Protein CBR-NBET-1.	0.464
CBG01377	nsf-1	A8WQ97	A8XVN9	Protein CBG01377.	Protein CBR-NSF-1.	0.524
CBG01377	rab-3	A8WQ97	A8WU73	Protein CBG01377.	Protein CBR-RAB-3.	0.447
CBG01377	ric-4	A8WQ97	A8X8S6	Protein CBG01377.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.610
CBG01377	rimb-1	A8WQ97	A8XLQ4	Protein CBG01377.	Protein CBR-TAG-168.	0.421
CBG01377	sec-22	A8WQ97	A8X5Q7	Protein CBG01377.	Protein CBR-SEC-22; Belongs to the synaptobrevin family.	0.692
CBG01377	sly-1	A8WQ97	A8XSJ5	Protein CBG01377.	Protein CBG18370; Belongs to the STXBP/unc-18/SEC1 family.	0.479
CBG01377	snap-1	A8WQ97	A8XD84	Protein CBG01377.	Protein CBR-SNAP-1.	0.721
CBG01377	snap-29	A8WQ97	A8X3C5	Protein CBG01377.	Protein CBR-SNAP-29.	0.610