(55 nodes) Endoplasmic reticulum organization network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tram-1	Translocating chain-associated membrane protein; Belongs to the TRAM family. (371 aa)
	emc-2	Protein CBG07111. (295 aa)
	emc-1	Protein CBG07074. (968 aa)
	CBG08027	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (297 aa)
	ile-2	Protein CBR-ILE-2. (347 aa)
	CBG08258	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (244 aa)
	CBG08519	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (192 aa)
	CBG09477	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (331 aa)
	CBG10705	Protein CBG10705. (578 aa)
	CBG10833	Protein CBG10833. (156 aa)
	CBG11513	Protein CBG11513. (463 aa)
	lpin-1	Protein CBG11512. (804 aa)
	CBG12782	Protein CBG12782. (1599 aa)
	CBG12785	Protein CBG12785. (548 aa)
	farl-11	Protein CBG13065. (976 aa)
	gbf-1	Protein CBR-GBF-1. (1990 aa)
	CBG13259	Protein CBG13259. (241 aa)
	CBG13486	Protein CBG13486. (627 aa)
	atln-2	Protein CBG13780. (462 aa)
	atln-1	Protein CBG13900. (482 aa)
	lnp-1	Endoplasmic reticulum junction formation protein lunapark-1; Plays a role in tubular endoplasmic reticulum network formation and maintenance (By similarity). May be involved in central nervous system development. Has a presynaptic role in neurotransmission. Likely to operate in synaptogenesis by regulating vesicular transport or localization. Required for correct localization of rab-3 and snb-1 (By similarity); Belongs to the lunapark family. (344 aa)
	ostd-1	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (284 aa)
	CBG15265	Receptor expression-enhancing protein. (235 aa)
	CBG15331	Receptor expression-enhancing protein. (162 aa)
	npp-25	Protein CBG15760. (266 aa)
	CBG17947	Protein CBG17947. (222 aa)
	CBG17972	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (123 aa)
	CBG18166	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (163 aa)
	cee-1	Protein CBG18187. (362 aa)
	CBG18908	Protein CBG18908. (85 aa)
	perm-3	ER membrane protein complex subunit 4; Belongs to the EMC4 family. (174 aa)
	CBG20367	Protein CBG20367. (188 aa)
	CBG21224	Receptor expression-enhancing protein. (210 aa)
	CBG28126	Protein CBG28126. (738 aa)
	CBG25682	Protein CBG25682. (291 aa)
	CBG19742	Protein jagunal homolog. (189 aa)
	CBG05695	Protein CBG05695. (234 aa)
	CBG04310	Protein CBG04310. (203 aa)
	CBG03818	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (123 aa)
	ile-1	Protein CBR-ILE-1. (491 aa)
	yop-1	Receptor expression-enhancing protein. (184 aa)
	vpr-1	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (254 aa)
	CBG03696	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (179 aa)
	CBG03552	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (160 aa)
	sec-31	Protein CBR-SEC-31. (1098 aa)
	CBG02637	Protein CBG02637. (113 aa)
	ccm-3	Protein CBG03050. (215 aa)
	CBG03052	Protein CBG03052. (74 aa)
	CBG03087	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (311 aa)
	CBG02246	Protein CBG02246. (169 aa)
	emc-3	ER membrane protein complex subunit 3. (234 aa)
	wrb-1	Protein CBR-WRB-1. (936 aa)
	asna-1	ATPase asna-1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] (345 aa)
	hut-1	Protein CBR-HUT-1. (354 aa)
	CBG23909	Receptor expression-enhancing protein. (135 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG02246	CBG05695	A8WS69	A8X0G8	Protein CBG02246.	Protein CBG05695.	0.918
CBG02246	CBG17947	A8WS69	A8XSM8	Protein CBG02246.	Protein CBG17947.	0.924
CBG02246	emc-1	A8WS69	A8X3R8	Protein CBG02246.	Protein CBG07074.	0.966
CBG02246	emc-2	A8WS69	A8X3N8	Protein CBG02246.	Protein CBG07111.	0.987
CBG02246	emc-3	A8WS69	A8WQU9	Protein CBG02246.	ER membrane protein complex subunit 3.	0.969
CBG02246	perm-3	A8WS69	A8XWS9	Protein CBG02246.	ER membrane protein complex subunit 4; Belongs to the EMC4 family.	0.967
CBG03052	ccm-3	A8WSW7	A8WSW9	Protein CBG03052.	Protein CBG03050.	0.540
CBG03052	farl-11	A8WSW7	A8XH00	Protein CBG03052.	Protein CBG13065.	0.771
CBG03552	CBG08258	A8WVB5	A8X657	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.453
CBG03552	CBG09477	A8WVB5	A8X909	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.457
CBG03552	CBG17972	A8WVB5	A8XSQ1	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.443
CBG03552	CBG21224	A8WVB5	A8XZK0	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	Receptor expression-enhancing protein.	0.477
CBG03696	vpr-1	A8WVM1	A8WVZ9	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.633
CBG04310	emc-3	A8WX76	A8WQU9	Protein CBG04310.	ER membrane protein complex subunit 3.	0.416
CBG04310	ile-1	A8WX76	A8WWJ0	Protein CBG04310.	Protein CBR-ILE-1.	0.486
CBG05695	CBG02246	A8X0G8	A8WS69	Protein CBG05695.	Protein CBG02246.	0.918
CBG05695	CBG17947	A8X0G8	A8XSM8	Protein CBG05695.	Protein CBG17947.	0.981
CBG05695	emc-1	A8X0G8	A8X3R8	Protein CBG05695.	Protein CBG07074.	0.977
CBG05695	emc-2	A8X0G8	A8X3N8	Protein CBG05695.	Protein CBG07111.	0.978
CBG05695	emc-3	A8X0G8	A8WQU9	Protein CBG05695.	ER membrane protein complex subunit 3.	0.975