(61 nodes) Phosphoric diester hydrolase activity network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ptr-9	Protein CBR-PTR-9. (861 aa)
	CBG23668	Protein CBG23668. (439 aa)
	CBG23963	Protein CBG23963. (349 aa)
	CBG24914	Protein CBG24914. (195 aa)
	ptr-16	Protein CBR-PTR-16. (808 aa)
	asm-3	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (584 aa)
	ptr-20	Protein CBR-PTR-20. (894 aa)
	ptr-13	Protein CBR-PTR-13. (852 aa)
	ptr-18	Protein CBR-PTR-18. (905 aa)
	pld-1	Phospholipase. (1402 aa)
	ptr-12	Protein CBR-PTR-12. (940 aa)
	ptr-21	Protein CBR-PTR-21. (913 aa)
	ptr-11	Protein CBR-PTR-11. (933 aa)
	fan-1	Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (878 aa)
	CBG05563	Protein CBG05563. (520 aa)
	plc-4	Phosphoinositide phospholipase C. (752 aa)
	CBG05849	Protein CBG05849. (356 aa)
	CBG05848	Protein CBG05848. (424 aa)
	egl-8	Phosphoinositide phospholipase C. (1528 aa)
	pde-2	Phosphodiesterase. (959 aa)
	ptr-3	Protein CBR-PTR-3. (927 aa)
	ptr-24	Protein CBR-PTR-24. (864 aa)
	nape-2	Protein CBR-NAPE-2. (181 aa)
	CBG09540	Protein CBG09540. (561 aa)
	asm-1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (562 aa)
	pde-5	Phosphodiesterase. (715 aa)
	CBG12510	Protein CBG12510. (653 aa)
	pde-4	Phosphodiesterase. (785 aa)
	gpcp-2	Protein CBG13338. (805 aa)
	apn-1	Protein CBR-APN-1. (389 aa)
	gpcp-1	Protein CBG14135. (616 aa)
	ptr-4	Protein CBR-PTR-4. (989 aa)
	pll-1	Phosphoinositide phospholipase C. (1083 aa)
	CBG15798	Protein CBG15798. (197 aa)
	CBG16011	Protein CBG16011. (275 aa)
	ptr-5	Protein CBR-PTR-5. (1017 aa)
	CBG16362	Protein CBG16362. (580 aa)
	asm-2	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
	CBG17582	Protein CBG17582. (396 aa)
	CBG17584	Protein CBG17584. (1313 aa)
	Cbr-frm-9	Protein CBR-FRM-9. (455 aa)
	plc-1	Phosphoinositide phospholipase C. (1917 aa)
	CBG18375	Protein CBG18375. (1247 aa)
	pde-6	Phosphodiesterase. (705 aa)
	plc-2	Phosphoinositide phospholipase C. (933 aa)
	exo-3	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. (290 aa)
	plc-3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1308 aa)
	CBG18751	Protein CBG18751. (387 aa)
	CBG18823	5'-tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. (337 aa)
	ptr-15	Protein CBR-PTR-15. (849 aa)
	CBG19099	Protein CBG19099. (674 aa)
	CBG19208	Protein CBG19208. (1082 aa)
	ptr-23	Protein CBR-PTR-23. (982 aa)
	ptr-22	Protein CBR-PTR-22. (881 aa)
	pde-1	Phosphodiesterase. (662 aa)
	ptr-8	Protein CBR-PTR-8. (905 aa)
	pde-3	Phosphodiesterase. (504 aa)
	CBG20887	Protein CBG20887. (209 aa)
	CBG22509	Protein CBG22509. (421 aa)
	CBG23426	Protein CBG23426. (249 aa)
	CBG26374	Protein CBG26374. (61 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG12510	CBG23668	A8XFX9	A8WJ20	Protein CBG12510.	Protein CBG23668.	0.552
CBG12510	asm-1	A8XFX9	A8XCM9	Protein CBG12510.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.	0.918
CBG15798	egl-8	A8XMT9	A8X232	Protein CBG15798.	Phosphoinositide phospholipase C.	0.405
CBG15798	plc-3	A8XMT9	A8XTZ1	Protein CBG15798.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.446
CBG16362	pld-1	A8XNL7	A8WUL4	Protein CBG16362.	Phospholipase.	0.408
CBG17582	egl-8	A8XRA1	A8X232	Protein CBG17582.	Phosphoinositide phospholipase C.	0.411
CBG17582	plc-3	A8XRA1	A8XTZ1	Protein CBG17582.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.471
CBG17584	Cbr-frm-9	A8XRA3	A8XRA4	Protein CBG17584.	Protein CBR-FRM-9.	0.550
CBG17584	egl-8	A8XRA3	A8X232	Protein CBG17584.	Phosphoinositide phospholipase C.	0.411
CBG17584	plc-1	A8XRA3	A8XRA5	Protein CBG17584.	Phosphoinositide phospholipase C.	0.548
CBG17584	plc-3	A8XRA3	A8XTZ1	Protein CBG17584.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.471
CBG18751	CBG22509	A8XU18	A8Y2F6	Protein CBG18751.	Protein CBG22509.	0.604
CBG18751	apn-1	A8XU18	A8XHT2	Protein CBG18751.	Protein CBR-APN-1.	0.815
CBG18823	CBG22509	A8XU68	A8Y2F6	5'-tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals.	Protein CBG22509.	0.842
CBG19099	pld-1	A8XUS6	A8WUL4	Protein CBG19099.	Phospholipase.	0.945
CBG20887	pde-2	A8XYV7	A8X375	Protein CBG20887.	Phosphodiesterase.	0.461
CBG20887	pde-4	A8XYV7	A8XGW5	Protein CBG20887.	Phosphodiesterase.	0.461
CBG20887	pde-5	A8XYV7	A8XFQ4	Protein CBG20887.	Phosphodiesterase.	0.461
CBG20887	pde-6	A8XYV7	A8XTJ4	Protein CBG20887.	Phosphodiesterase.	0.527
CBG22509	CBG18751	A8Y2F6	A8XU18	Protein CBG22509.	Protein CBG18751.	0.604