(33 nodes) Positive regulation of autophagy network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CBG26587	Protein CBG26587. (599 aa)
	unc-51	Protein CBR-UNC-51. (875 aa)
	CBG24636	Protein CBG24636. (770 aa)
	CBG24891	Protein CBG24891. (259 aa)
	atg-18	Protein CBR-ATG-18. (406 aa)
	CBG01467	Protein CBG01467. (383 aa)
	nprl-3	Protein CBG01588. (490 aa)
	CBG01923	Protein CBG01923. (2041 aa)
	lgg-1	Protein lgg. (123 aa)
	pink-1	Protein CBR-PINK-1. (1237 aa)
	sesn-1	Protein CBG03915. (557 aa)
	CBG03830	Protein CBG03830. (415 aa)
	epg-8	Protein CBR-EPG-8. (431 aa)
	hlh-30	Protein CBR-HLH-30. (392 aa)
	CBG05575	Protein CBG05575. (166 aa)
	pha-4	Protein CBR-PHA-4. (477 aa)
	atg-7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. (671 aa)
	lgg-2	Protein lgg. (130 aa)
	nprl-2	Protein CBG05911. (756 aa)
	laat-1	Protein CBG07028. (310 aa)
	rbg-1	Protein CBR-RBG-1. (922 aa)
	cup-5	Protein CBR-CUP-5. (650 aa)
	CBG24924	Protein CBG24924. (389 aa)
	mtm-3	Protein CBR-MTM-3. (1008 aa)
	epg-7	Protein CBR-ATG-11. (1313 aa)
	atg-2	Protein CBR-ATG-2. (2305 aa)
	rsks-1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (540 aa)
	CBG14564	Protein CBG14564; Belongs to the protein kinase superfamily. (342 aa)
	smcr-8	Protein CBG16529. (511 aa)
	hsf-1	Protein CBR-HSF-1. (504 aa)
	lipl-4	Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (423 aa)
	CBG21231	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (461 aa)
	CBG21229	Protein CBG21229. (1384 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG01467	CBG14564	A8WQM3	A8XK73	Protein CBG01467.	Protein CBG14564; Belongs to the protein kinase superfamily.	0.616
CBG01467	CBG24636	A8WQM3	A8WL56	Protein CBG01467.	Protein CBG24636.	0.838
CBG01467	CBG24924	A8WQM3	H8WHA0	Protein CBG01467.	Protein CBG24924.	0.400
CBG01467	atg-18	A8WQM3	A8WQM1	Protein CBG01467.	Protein CBR-ATG-18.	0.901
CBG01467	atg-2	A8WQM3	A8XC81	Protein CBG01467.	Protein CBR-ATG-2.	0.993
CBG01467	atg-7	A8WQM3	A8X151	Protein CBG01467.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.	0.862
CBG01467	epg-7	A8WQM3	A8XC23	Protein CBG01467.	Protein CBR-ATG-11.	0.544
CBG01467	epg-8	A8WQM3	A8WWV2	Protein CBG01467.	Protein CBR-EPG-8.	0.712
CBG01467	hlh-30	A8WQM3	A8WZP5	Protein CBG01467.	Protein CBR-HLH-30.	0.400
CBG01467	lgg-1	A8WQM3	A8WTV5	Protein CBG01467.	Protein lgg.	0.885
CBG01467	lgg-2	A8WQM3	A8X182	Protein CBG01467.	Protein lgg.	0.779
CBG01467	unc-51	A8WQM3	A8WL55	Protein CBG01467.	Protein CBR-UNC-51.	0.838
CBG03830	CBG14564	A8WWV0	A8XK73	Protein CBG03830.	Protein CBG14564; Belongs to the protein kinase superfamily.	0.519
CBG05575	CBG24924	A8X067	H8WHA0	Protein CBG05575.	Protein CBG24924.	0.626
CBG05575	hlh-30	A8X067	A8WZP5	Protein CBG05575.	Protein CBR-HLH-30.	0.626
CBG05575	hsf-1	A8X067	A8XTY3	Protein CBG05575.	Protein CBR-HSF-1.	0.633
CBG05575	lgg-1	A8X067	A8WTV5	Protein CBG05575.	Protein lgg.	0.634
CBG05575	lipl-4	A8X067	A8XUG3	Protein CBG05575.	Lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.630
CBG05575	rsks-1	A8X067	A8XHB3	Protein CBG05575.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.630
CBG05575	unc-51	A8X067	A8WL55	Protein CBG05575.	Protein CBR-UNC-51.	0.452