STRINGSTRING
dos-1 dos-1 pde-2 pde-2 egl-8 egl-8 hecd-1 hecd-1 CBG05921 CBG05921 ragc-1 ragc-1 bre-5 bre-5 gcy-22 gcy-22 unc-77 unc-77 CBG05218 CBG05218 nekl-4 nekl-4 cdf-1 cdf-1 actl-1 actl-1 CBG02568 CBG02568 sma-6 sma-6 trf-2 trf-2 stg-1 stg-1 rict-1 rict-1 CBG02786 CBG02786 raga-1 raga-1 ccm-3 ccm-3 CBG03052 CBG03052 ndk-1 ndk-1 CBG02176 CBG02176 tsp-21 tsp-21 CBG01923 CBG01923 svh-1 svh-1 tpa-1 tpa-1 CBG01732 CBG01732 CBG01733 CBG01733 CBG01796 CBG01796 unc-26 unc-26 asna-1 asna-1 daf-7 daf-7 CBG24775 CBG24775 dos-3 dos-3 rps-3 rps-3 CBG24198 CBG24198 CBG24197 CBG24197 CBG23828 CBG23828 gar-3 gar-3 ego-2 ego-2 riok-1 riok-1 CBG03577 CBG03577 npp-18 npp-18 fem-3 fem-3 vha-12 vha-12 ric-3 ric-3 CBG08088 CBG08088 lmtr-5 lmtr-5 Cbr-aex-1 Cbr-aex-1 CBG26587 CBG26587 CBG25886 CBG25886 CBG27393 CBG27393 lmtr-3 lmtr-3 daf-11 daf-11 frm-7 frm-7 ksr-1 ksr-1 sma-10 sma-10 pin-2 pin-2 dyb-1 dyb-1 egl-30 egl-30 bre-4 bre-4 Cbr-daf-25 Cbr-daf-25 CBG22065 CBG22065 oma-2 oma-2 unc-129 unc-129 praf-3 praf-3 trf-1 trf-1 mig-14 mig-14 tig-3 tig-3 mec-15 mec-15 soc-2 soc-2 sol-2 sol-2 spdl-1 spdl-1 rgef-1 rgef-1 dbl-1 dbl-1 CBG18955 CBG18955 ubh-1 ubh-1 ubr-5 ubr-5 prde-1 prde-1 pde-6 pde-6 fsn-1 fsn-1 CBG18064 CBG18064 sel-5 sel-5 Cbr-tag-243 Cbr-tag-243 gipc-2 gipc-2 osm-7 osm-7 nca-2 nca-2 CBG18204 CBG18204 CBG17418 CBG17418 gcy-9 gcy-9 slo-2 slo-2 unc-18 unc-18 sma-3 sma-3 rod-1 rod-1 smcr-8 smcr-8 vha-20 vha-20 sur-7 sur-7 osm-11 osm-11 daf-2 daf-2 stg-2 stg-2 Cbr-dys-1 Cbr-dys-1 dys-1 dys-1 unc-75 unc-75 let-765 let-765 unc-40 unc-40 gnrr-4 gnrr-4 unc-97 unc-97 tsp-14 tsp-14 CBG14553 CBG14553 dpy-23 dpy-23 npp-20 npp-20 CBG13699 CBG13699 lsy-13 lsy-13 rho-1 rho-1 ubh-4 ubh-4 tph-1 tph-1 CBG12570 CBG12570 daf-16 daf-16 mel-26 mel-26 CBG12421 CBG12421 unc-29 unc-29 sup-17 sup-17 csnk-1 csnk-1 aex-1 aex-1 sue-1 sue-1 CBG11925 CBG11925 sol-1 sol-1 hop-1 hop-1 unc-73 unc-73 lin-44 lin-44 lmtr-2 lmtr-2 rpy-1 rpy-1 CBG11220 CBG11220 sphk-1 sphk-1 svh-2 svh-2 CBG10838 CBG10838 unc-10 unc-10 hen-1 hen-1 CBG10472 CBG10472 CBG10300 CBG10300 unc-16 unc-16 egl-3 egl-3 CBG09543 CBG09543 Cbr-gcy-6 Cbr-gcy-6 daf-4 daf-4 ida-1 ida-1 tsp-12 tsp-12 CBG03383 CBG03383 pink-1 pink-1 ptp-2 ptp-2 casy-1 casy-1 tig-2 tig-2 CBG08550 CBG08550 egl-21 egl-21 aex-3 aex-3 sel-12 sel-12 unc-1 unc-1 sel-7 sel-7 CBG07264 CBG07264 rog-1 rog-1 unc-32 unc-32
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dos-1Protein CBR-DOS-1. (316 aa)
pde-2Phosphodiesterase. (959 aa)
egl-8Phosphoinositide phospholipase C. (1528 aa)
hecd-1Protein CBR-HECD-1. (2727 aa)
CBG05921Protein CBG05921. (299 aa)
ragc-1Protein CBR-RAGC-1. (338 aa)
bre-5Hexosyltransferase. (281 aa)
gcy-22Guanylate cyclase. (1076 aa)
unc-77Protein CBR-NCA-1. (1883 aa)
CBG05218Protein CBG05218. (260 aa)
nekl-4Protein CBR-NEKL-4. (1572 aa)
cdf-1Protein CBR-CDF-1. (545 aa)
actl-1Protein CBG05082. (369 aa)
CBG02568Protein CBG02568. (128 aa)
sma-6Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (629 aa)
trf-2Protein CBG23748. (294 aa)
stg-1Protein CBR-STG-1. (843 aa)
rict-1Protein CBG02784. (830 aa)
CBG02786Protein CBG02786. (805 aa)
raga-1Protein CBR-RAGA-1. (312 aa)
ccm-3Protein CBG03050. (215 aa)
CBG03052Protein CBG03052. (74 aa)
ndk-1Nucleoside diphosphate kinase. (153 aa)
CBG02176Protein CBG02176. (132 aa)
tsp-21Tetraspanin. (298 aa)
CBG01923Protein CBG01923. (2041 aa)
svh-1Protein CBR-TRY-2; Belongs to the peptidase S1 family. (921 aa)
tpa-1Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (705 aa)
CBG01732Protein CBG01732. (549 aa)
CBG01733Protein CBG01733. (299 aa)
CBG01796Protein CBG01796. (564 aa)
unc-26Protein CBR-UNC-26. (1123 aa)
asna-1ATPase asna-1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] (345 aa)
daf-7Protein CBR-DAF-7. (376 aa)
CBG24775Protein CBG24775. (209 aa)
dos-3Protein CBG24557. (467 aa)
rps-3Protein CBR-RPS-3; Belongs to the universal ribosomal protein uS3 family. (247 aa)
CBG24198Protein CBG24198. (188 aa)
CBG24197Protein CBG24197. (188 aa)
CBG23828Protein CBG23828. (269 aa)
gar-3Protein CBR-GAR-3; Belongs to the G-protein coupled receptor 1 family. (609 aa)
ego-2Protein CBR-EGO-2. (1434 aa)
riok-1Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (515 aa)
CBG03577Protein CBG03577. (448 aa)
npp-18Nucleoporin SEH1; Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus; Belongs to the WD repeat SEC13 family. (366 aa)
fem-3Sex-determination protein fem-3; Required for male development. In XO (male) animals, fem-3 directs male differentiation in all tissues. In XX (hermaphrodite animals), it specifies the first 80 or so germ cells to be sperm. Negatively regulates male development when bound to tra-2. (409 aa)
vha-12Probable V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Required for necrotic cell death and epidermal cell fusion (By similarity). Belongs to the ATPase alpha/beta chains family. (491 aa)
ric-3Resistance to inhibitors of cholinesterase protein 3; Required for maturation and cell surface expression of acetylcholine receptors. (385 aa)
CBG08088Protein CBG08088. (282 aa)
lmtr-5Protein CBG25826. (95 aa)
Cbr-aex-1Protein CBG26592. (97 aa)
CBG26587Protein CBG26587. (599 aa)
CBG25886Protein CBG25886. (111 aa)
CBG27393Protein CBG27393. (341 aa)
lmtr-3Protein CBG23109. (147 aa)
daf-11Guanylate cyclase. (1277 aa)
frm-7Protein CBR-FRM-7. (967 aa)
ksr-1Protein CBR-KSR-1. (812 aa)
sma-10Protein CBG22529. (879 aa)
pin-2Protein CBR-PIN-2. (328 aa)
dyb-1Dystrobrevin. (622 aa)
egl-30Protein CBR-EGL-30. (388 aa)
bre-4Beta-1,4-N-acetylgalactosaminyltransferase bre-4; Catalyzes the transfer of galactose onto proteins or lipids. Required for susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2 and bre-3 (By similarity); Belongs to the glycosyltransferase 7 family. (384 aa)
Cbr-daf-25Protein CBR-DAF-25. (615 aa)
CBG22065Protein CBG22065. (207 aa)
oma-2Protein CBR-OMA-2. (379 aa)
unc-129Protein CBR-UNC-129. (404 aa)
praf-3PRA1 family protein. (189 aa)
trf-1Protein CBR-TRF-1. (439 aa)
mig-14Protein CBR-MIG-14. (548 aa)
tig-3Protein CBR-TIG-3. (225 aa)
mec-15Protein CBG20219. (368 aa)
soc-2Leucine-rich repeat protein soc-2; Acts as a Ras effector and participates in MAPK pathway activation. Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulates Raf activity at specialized signaling complexes upon Ras activation. Required for vulval development. Involved in fluid homeostasis. Plays a role in nicotinic acetylcholine receptor (nAChR)- mediated sensitivity to nicotine; Belongs to the SHOC2 family. (559 aa)
sol-2Protein CBG19743. (299 aa)
spdl-1Protein CBR-SPDL-1. (501 aa)
rgef-1Protein CBR-RGEF-1. (676 aa)
dbl-1Protein CBR-DBL-1. (373 aa)
CBG18955Protein CBG18955. (148 aa)
ubh-1Ubiquitin carboxyl-terminal hydrolase. (216 aa)
ubr-5Protein CBG18920. (2963 aa)
prde-1Protein CBG18603. (553 aa)
pde-6Phosphodiesterase. (705 aa)
fsn-1F-box/SPRY domain-containing protein 1; Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf-2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM and [...] (332 aa)
CBG18064Protein CBG18064. (987 aa)
sel-5Protein CBR-SEL-5. (1078 aa)
Cbr-tag-243Protein CBR-TAG-243. (230 aa)
gipc-2Protein CBG17992. (363 aa)
osm-7Protein CBR-OSM-7. (697 aa)
nca-2Protein CBR-NCA-2. (1809 aa)
CBG18204Protein CBG18204. (260 aa)
CBG17418Protein CBG17418. (2818 aa)
gcy-9Guanylate cyclase. (1156 aa)
slo-2Protein CBR-SLO-2. (1098 aa)
unc-18Protein CBR-UNC-18; Belongs to the STXBP/unc-18/SEC1 family. (590 aa)
sma-3Dwarfin sma. (365 aa)
rod-1Protein CBR-ROD-1. (2213 aa)
smcr-8Protein CBG16529. (511 aa)
vha-20Protein CBG16307. (329 aa)
sur-7Protein CBR-SUR-7. (365 aa)
osm-11Protein CBR-OSM-11. (188 aa)
daf-2Protein CBR-DAF-2. (1840 aa)
stg-2Protein CBR-STG-2. (373 aa)
Cbr-dys-1Protein CBR-DYS-1. (2353 aa)
dys-1Protein CBG15371. (1276 aa)
unc-75Protein CBR-UNC-75. (515 aa)
let-765Protein CBR-LET-765. (1839 aa)
unc-40Protein CBR-UNC-40. (1407 aa)
gnrr-4Protein CBR-GNRR-4. (531 aa)
unc-97LIM domain-containing protein. (353 aa)
tsp-14Tetraspanin. (440 aa)
CBG14553Protein CBG14553. (5515 aa)
dpy-23Protein CBR-DPY-23; Belongs to the adaptor complexes medium subunit family. (435 aa)
npp-20Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat; Belongs to the WD repeat SEC13 family. (306 aa)
CBG13699Protein CBG13699. (277 aa)
lsy-13Protein CBG13684. (277 aa)
rho-1Protein CBR-RHO-1. (192 aa)
ubh-4Ubiquitin carboxyl-terminal hydrolase. (326 aa)
tph-1Protein CBR-TPH-1. (546 aa)
CBG12570Protein CBG12570. (1945 aa)
daf-16Protein CBR-DAF-16. (497 aa)
mel-26Protein CBR-MEL-26. (394 aa)
CBG12421Protein CBG12421. (145 aa)
unc-29Protein CBR-UNC-29. (491 aa)
sup-17Protein CBR-SUP-17. (920 aa)
csnk-1Protein CBR-CSNK-1; Belongs to the protein kinase superfamily. (460 aa)
aex-1Protein CBR-AEX-1. (1034 aa)
sue-1Protein CBR-SUE-1. (539 aa)
CBG11925Protein CBG11925. (118 aa)
sol-1Protein CBR-SOL-1. (596 aa)
hop-1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (358 aa)
unc-73Protein CBR-UNC-73. (1618 aa)
lin-44Abnormal cell lineage protein 44; Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Affects male tail development, vulval precursor cell specification and egg laying. Involved in morphogenesis by influencing polarity of asymmetric cell divisions of the B, U, and F cells in the male, and the T cell in males and hermaphrodites. Controls spindle orientation in B-gamma cell division during male copulatory spicule development. Involved in specification of the P7.p lineage during vulval development. Has a role in providing polarity and default lin-17 [...] (341 aa)
lmtr-2Protein CBG11395. (124 aa)
rpy-1Protein CBR-RPY-1. (613 aa)
CBG11220Protein CBG11220. (299 aa)
sphk-1Protein CBR-SPHK-1. (423 aa)
svh-2Protein CBG10839; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1120 aa)
CBG10838Protein CBG10838. (249 aa)
unc-10Protein CBR-UNC-10. (1636 aa)
hen-1Protein CBR-HEN-1. (118 aa)
CBG10472Protein CBG10472. (597 aa)
CBG10300Protein CBG10300. (675 aa)
unc-16Protein CBR-UNC-16. (1158 aa)
egl-3Protein CBR-EGL-3; Belongs to the peptidase S8 family. (662 aa)
CBG09543Protein CBG09543. (121 aa)
Cbr-gcy-6Guanylate cyclase. (1104 aa)
daf-4Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (742 aa)
ida-1Protein CBR-IDA-1. (722 aa)
tsp-12Tetraspanin. (308 aa)
CBG03383Protein CBG03383. (567 aa)
pink-1Protein CBR-PINK-1. (1237 aa)
ptp-2Protein CBR-PTP-2. (692 aa)
casy-1Protein CBR-CASY-1. (983 aa)
tig-2Protein CBR-TIG-2. (364 aa)
CBG08550Protein CBG08550. (255 aa)
egl-21Protein CBR-EGL-21. (473 aa)
aex-3Protein CBR-AEX-3. (1500 aa)
sel-12Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (450 aa)
unc-1Protein CBR-UNC-1. (285 aa)
sel-7Protein CBR-SEL-7. (317 aa)
CBG07264Protein CBG07264. (300 aa)
rog-1Protein CBR-ROG-1. (661 aa)
unc-32V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (953 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
Server load: low (20%) [HD]