STRINGSTRING
bcat-1 bcat-1 cysl-2 cysl-2 acs-7 acs-7 mtrr-1 mtrr-1 asns-1 asns-1 fat-1 fat-1 fat-2 fat-2 CBG01775 CBG01775 seld-1 seld-1 cbs-1 cbs-1 cysl-1 cysl-1 CBG01968 CBG01968 CBG01970 CBG01970 CBG01975 CBG01975 dbt-1 dbt-1 agxt-1 agxt-1 pah-1 pah-1 mecr-1 mecr-1 CBG02813 CBG02813 upb-1 upb-1 dhs-5 dhs-5 CBG03380 CBG03380 fat-3 fat-3 fat-4 fat-4 CBG03789 CBG03789 glna-1 glna-1 CBG05537 CBG05537 CBG06229 CBG06229 CBG06193 CBG06193 CBG06191 CBG06191 fat-6 fat-6 CBG05948 CBG05948 CBG05881 CBG05881 elo-3 elo-3 CBG07192 CBG07192 CBG07184 CBG07184 CBG07019 CBG07019 djr-1.1 djr-1.1 djr-1.2 djr-1.2 CBG06975 CBG06975 CBG06970 CBG06970 pod-2 pod-2 lim-6 lim-6 abhd-3.2 abhd-3.2 CBG08117 CBG08117 CBG08349 CBG08349 CBG08368 CBG08368 pqn-60 pqn-60 CBG08973 CBG08973 sqv-4 sqv-4 acly-2 acly-2 Cbr-rpl-16 Cbr-rpl-16 elo-4 elo-4 CBG10258 CBG10258 cysl-3 cysl-3 CBG10451 CBG10451 CBG10452 CBG10452 CBG10453 CBG10453 CBG10454 CBG10454 CBG10455 CBG10455 art-1 art-1 glna-3 glna-3 pges-2 pges-2 dhs-25 dhs-25 acly-1 acly-1 fat-5 fat-5 cth-2 cth-2 CBG24871 CBG24871 CBG25013 CBG25013 alh-13 alh-13 CBG00142 CBG00142 CBG00232 CBG00232 CBG00376 CBG00376 elo-2 elo-2 CBG00666 CBG00666 pyr-1 pyr-1 CBG11442 CBG11442 Cbr-stdh-1 Cbr-stdh-1 CBG11572 CBG11572 CBG12230 CBG12230 fath-1 fath-1 dhfr-1 dhfr-1 fasn-1 fasn-1 CBG12517 CBG12517 mthf-1 mthf-1 CBG12961 CBG12961 CBG12968 CBG12968 CBG13312 CBG13312 CBG13458 CBG13458 glna-2 glna-2 aass-1 aass-1 CBG13739 CBG13739 gln-3 gln-3 dhs-27 dhs-27 pks-1 pks-1 dpyd-1 dpyd-1 gln-1 gln-1 flu-2 flu-2 Cbr-elo-8 Cbr-elo-8 asns-2 asns-2 CBG15622 CBG15622 unc-25 unc-25 got-1.2 got-1.2 Cbr-got-1.3 Cbr-got-1.3 CBG16221 CBG16221 CBG17045 CBG17045 CBG17652 CBG17652 CBG18225 CBG18225 dhs-11 dhs-11 mlcd-1 mlcd-1 lipl-4 lipl-4 hpo-8 hpo-8 CBG19472 CBG19472 Cbr-gln-5 Cbr-gln-5 elo-6 elo-6 elo-5 elo-5 elo-1 elo-1 elo-7 elo-7 metr-1 metr-1 gln-2.1 gln-2.1 CBG20736 CBG20736 gln-2.2 gln-2.2 elo-9 elo-9 dld-1 dld-1 CBG22021 CBG22021 cbl-1 cbl-1 Cbr-pqn-98 Cbr-pqn-98 CBG23511 CBG23511 kmo-1 kmo-1 pqn-53 pqn-53 CBG23334 CBG23334 CBG23332 CBG23332 CBG25505 CBG25505 CBG27484 CBG27484 CBG27228 CBG27228 oatr-1 oatr-1 cdo-1 cdo-1 let-767 let-767 mel-32 mel-32 haao-1 haao-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bcat-1Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (414 aa)
cysl-2Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (337 aa)
acs-7Protein CBG00883. (541 aa)
mtrr-1Protein CBR-MTRR-1. (683 aa)
asns-1Protein CBR-ASNS-1. (572 aa)
fat-1Protein CBR-FAT-1. (399 aa)
fat-2Protein CBR-FAT-2. (376 aa)
CBG01775Protein CBG01775. (264 aa)
seld-1Protein CBR-SELD-1. (380 aa)
cbs-1Protein CBR-CBS-2. (701 aa)
cysl-1Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (341 aa)
CBG01968Probable methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). (169 aa)
CBG01970Protein CBG01970. (116 aa)
CBG01975Protein CBG01975. (2174 aa)
dbt-1Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (482 aa)
agxt-1Serine--pyruvate aminotransferase. (413 aa)
pah-1Protein CBR-PAH-1. (458 aa)
mecr-1Protein CBR-MECR-1. (344 aa)
CBG02813Protein CBG02813. (349 aa)
upb-1Protein CBR-UPB-1. (371 aa)
dhs-5Protein CBR-DHS-5. (374 aa)
CBG03380Protein CBG03380; Belongs to the TPP enzyme family. (642 aa)
fat-3Protein CBR-FAT-3. (443 aa)
fat-4Protein CBR-FAT-4. (447 aa)
CBG03789Protein CBG03789; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (400 aa)
glna-1Protein CBR-GLNA-1. (825 aa)
CBG05537Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (389 aa)
CBG06229Protein CBG06229. (477 aa)
CBG06193Protein CBG06193. (457 aa)
CBG06191Protein CBG06191. (925 aa)
fat-6Protein CBR-FAT-6; Belongs to the fatty acid desaturase type 1 family. (338 aa)
CBG05948Protein CBG05948. (252 aa)
CBG05881Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (298 aa)
elo-3Elongation of very long chain fatty acids protein. (319 aa)
CBG07192Protein CBG07192. (187 aa)
CBG07184Protein CBG07184. (194 aa)
CBG07019Protein CBG07019. (346 aa)
djr-1.1Protein CBR-DJR-1.1. (187 aa)
djr-1.2Protein CBR-DJR-1.2. (192 aa)
CBG06975Protein CBG06975. (423 aa)
CBG069701,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase homolog 2; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene); Belongs to the acireductone dioxygenase (ARD) family. (159 aa)
pod-2Protein CBG07699. (2257 aa)
lim-6Protein CBR-LIM-6. (257 aa)
abhd-3.2Protein CBG08080. (375 aa)
CBG08117Protein CBG08117. (297 aa)
CBG08349Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (116 aa)
CBG08368Protein CBG08368. (253 aa)
pqn-60Protein CBG08422. (147 aa)
CBG08973Protein CBG08973. (492 aa)
sqv-4UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (481 aa)
acly-2ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1111 aa)
Cbr-rpl-16Protein CBR-RPL-16; Belongs to the universal ribosomal protein uL13 family. (584 aa)
elo-4Elongation of very long chain fatty acids protein. (292 aa)
CBG10258Protein CBG10258. (464 aa)
cysl-3Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (337 aa)
CBG10451Protein CBG10451. (415 aa)
CBG10452Protein CBG10452. (428 aa)
CBG10453Protein CBG10453. (428 aa)
CBG10454Protein CBG10454. (432 aa)
CBG10455Protein CBG10455. (252 aa)
art-1Protein CBR-ART-1. (329 aa)
glna-3Protein CBR-GLNA-3. (600 aa)
pges-2Protein CBG23755; Belongs to the GST superfamily. (350 aa)
dhs-25Protein CBR-DHS-25. (248 aa)
acly-1ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1106 aa)
fat-5Protein CBR-FAT-5; Belongs to the fatty acid desaturase type 1 family. (333 aa)
cth-2Protein CBG24746. (392 aa)
CBG24871Protein CBG24871. (125 aa)
CBG25013Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (338 aa)
alh-13Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (802 aa)
CBG001421,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (178 aa)
CBG00232Protein CBG00232. (345 aa)
CBG00376Protein CBG00376. (1665 aa)
elo-2Elongation of very long chain fatty acids protein. (271 aa)
CBG00666Protein CBG00666. (502 aa)
pyr-1Protein CBR-PYR-1. (2090 aa)
CBG11442Protein CBG11442; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (311 aa)
Cbr-stdh-1Protein CBR-STDH-1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (315 aa)
CBG11572Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (366 aa)
CBG12230Protein CBG12230. (124 aa)
fath-1Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (316 aa)
dhfr-1Protein CBG12356; Belongs to the dihydrofolate reductase family. (189 aa)
fasn-1Protein CBR-FASN-1. (2731 aa)
CBG12517Protein CBG12517. (325 aa)
mthf-1Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (724 aa)
CBG12961Protein CBG12961. (278 aa)
CBG12968S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (285 aa)
CBG13312Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (133 aa)
CBG134581,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase homolog 3; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene); Belongs to the acireductone dioxygenase (ARD) family. (158 aa)
glna-2Protein CBR-GLNA-2. (662 aa)
aass-1Protein CBG13546. (934 aa)
CBG13739Protein CBG13739. (305 aa)
gln-3Glutamine synthetase. (385 aa)
dhs-27Protein CBR-DHS-27. (763 aa)
pks-1Protein CBG14683. (7813 aa)
dpyd-1Probable dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil (By similarity). Belongs to the dihydropyrimidine dehydrogenase family. (1053 aa)
gln-1Protein CBR-GLN-1; Belongs to the glutamine synthetase family. (385 aa)
flu-2Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (483 aa)
Cbr-elo-8Elongation of very long chain fatty acids protein. (291 aa)
asns-2Protein CBR-ASNS-2. (567 aa)
CBG15622Protein CBG15622. (247 aa)
unc-25Protein CBR-UNC-25. (510 aa)
got-1.2Aspartate aminotransferase. (408 aa)
Cbr-got-1.3Protein CBR-GOT-1.3. (397 aa)
CBG16221Protein CBG16221. (279 aa)
CBG17045Protein CBG17045; Belongs to the fatty acid desaturase type 1 family. (338 aa)
CBG17652Protein CBG17652. (427 aa)
CBG18225Protein CBG18225. (345 aa)
dhs-11Protein CBR-DHS-11. (244 aa)
mlcd-1Protein CBG18041. (442 aa)
lipl-4Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (423 aa)
hpo-8Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (218 aa)
CBG19472Protein CBG19472. (216 aa)
Cbr-gln-5Protein CBR-GLN-5; Belongs to the glutamine synthetase family. (383 aa)
elo-6Elongation of very long chain fatty acids protein. (272 aa)
elo-5Elongation of very long chain fatty acids protein. (274 aa)
elo-1Elongation of very long chain fatty acids protein. (290 aa)
elo-7Elongation of very long chain fatty acids protein. (308 aa)
metr-1Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). (1273 aa)
gln-2.1Protein CBG20640; Belongs to the glutamine synthetase family. (367 aa)
CBG20736Protein CBG20736; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (322 aa)
gln-2.2Protein CBR-GLN-2; Belongs to the glutamine synthetase family. (367 aa)
elo-9Elongation of very long chain fatty acids protein. (286 aa)
dld-1Dihydrolipoyl dehydrogenase. (495 aa)
CBG22021Phosphoserine aminotransferase. (369 aa)
cbl-1Protein CBG22025. (414 aa)
Cbr-pqn-98Protein CBR-PQN-98. (144 aa)
CBG23511Protein CBG23511. (280 aa)
kmo-1Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (461 aa)
pqn-53Protein CBR-PQN-53. (348 aa)
CBG23334Protein CBG23334. (316 aa)
CBG23332Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (249 aa)
CBG25505Protein CBG25505. (207 aa)
CBG27484Protein CBG27484. (64 aa)
CBG27228Protein CBG27228. (1131 aa)
oatr-1Protein CBG09115; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (422 aa)
cdo-1Cysteine dioxygenase; Belongs to the cysteine dioxygenase family. (190 aa)
let-767Very-long-chain 3-oxooacyl-coA reductase let-767; Required for branched chain fatty acid synthesis. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. Very long-chain fatty acids (VLCFAs) serve as precursors for ceramide and sphingolipids. May also be required for sterol hormone production (By similarity). (316 aa)
mel-32Serine hydroxymethyltransferase; Interconversion of serine and glycine. (511 aa)
haao-13-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (281 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.