(74 nodes) Nuclear body network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CBG20414	Protein CBG20414. (335 aa)
	pqbp-1.1	Protein CBR-PQBP-1.2. (272 aa)
	syd-9	Protein CBR-SYD-9. (429 aa)
	pfs-2	Protein CBR-PFS-2. (814 aa)
	fib-1	Protein CBR-FIB-1. (350 aa)
	CBG12024	Protein CBG12024. (806 aa)
	CBG12064	Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA- mediated gene silencing (RNAi) by miRNAs (By similarity). Belongs to the ARS2 family. (715 aa)
	prp-4	Protein CBR-PRP-4. (496 aa)
	CBG12463	Protein CBG12463. (292 aa)
	CBG12605	Protein CBG12605. (283 aa)
	toe-4	Protein CBR-TOE-4. (540 aa)
	pqn-37	Protein CBR-PQN-37. (562 aa)
	sup-12	Protein CBR-SUP-12. (252 aa)
	mltn-13	Protein CBR-MLTN-13. (752 aa)
	CBG14713	Protein CBG14713. (113 aa)
	CBG14893	Protein CBG14893. (521 aa)
	CBG15138	Protein CBG15138. (300 aa)
	CBG15334	Protein CBG15334. (664 aa)
	unc-75	Protein CBR-UNC-75. (515 aa)
	frg-1	Protein CBR-FRG-1. (281 aa)
	CBG16740	Protein CBG16740. (609 aa)
	rsp-6	Protein CBR-RSP-6. (173 aa)
	rnp-4	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (142 aa)
	CBG18142	Protein CBG18142. (1438 aa)
	hsf-1	Protein CBR-HSF-1. (504 aa)
	CBG18823	5'-tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. (337 aa)
	rmh-2	Protein CBG19410. (602 aa)
	let-756	Protein CBR-LET-756; Belongs to the heparin-binding growth factors family. (473 aa)
	hinf-1	Protein CBG19711. (586 aa)
	CBG20393	Protein CBG20393. (622 aa)
	CBG10243	Protein CBG10243. (387 aa)
	rsr-2	Protein CBR-RSR-2. (498 aa)
	parn-2	Protein CBG20934. (429 aa)
	CBG21521	Protein CBG21521. (151 aa)
	ztf-2	Protein CBR-ZTF-2. (355 aa)
	ubc-3	Protein CBR-UBC-3; Belongs to the ubiquitin-conjugating enzyme family. (244 aa)
	rbm-25	Protein CBG23510. (703 aa)
	rnp-1	Protein CBR-RNP-1. (286 aa)
	CBG25779	Protein CBG25779. (821 aa)
	CBG25942	Protein CBG25942. (194 aa)
	CBG25094	Protein CBG25094. (323 aa)
	nrde-2	Protein CBR-NRDE-2. (951 aa)
	uaf-1	Splicing factor U2AF 65 kDa subunit; Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity). (488 aa)
	CBG23571	Protein CBG23571. (1136 aa)
	smn-1	Protein CBR-SMN-1. (194 aa)
	sut-2	Protein CBR-SUT-2. (722 aa)
	exc-7	Protein CBR-EXC-7. (676 aa)
	set-15	Protein CBR-SET-15. (621 aa)
	nlp-2	Protein CBR-NLP-2. (161 aa)
	rmh-1	Protein CBG02237. (944 aa)
	mus-101	Protein CBR-MUS-101. (1175 aa)
	let-858	Pre-mRNA-splicing factor CWC22 homolog; Required for early embryogenesis and tissue differentiation. Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity); Belongs to the CWC22 family. (935 aa)
	rsp-2	Protein CBR-RSP-2. (256 aa)
	vab-23	Protein CBR-VAB-23. (260 aa)
	rsp-5	Protein CBR-RSP-5. (150 aa)
	eif-2d	Protein CBG02479. (548 aa)
	rsp-4	Protein CBR-RSP-4. (125 aa)
	CBG03465	Protein CBG03465. (352 aa)
	rbd-1	Protein CBR-RBD-1. (877 aa)
	CBG03544	Protein CBG03544. (474 aa)
	morc-1	Protein CBR-MORC-1. (870 aa)
	rsp-3	Protein CBR-RSP-3. (258 aa)
	cpf-2	Protein CBR-CPF-2. (319 aa)
	eri-7	Protein CBG03999. (897 aa)
	CBG03715	Protein CBG03715. (137 aa)
	CBG04254	Protein CBG04254. (80 aa)
	hecd-1	Protein CBR-HECD-1. (2727 aa)
	nfki-1	Protein CBG07688. (622 aa)
	rsy-1	Protein CBR-RSY-1. (579 aa)
	tcab-1	Protein CBG08747. (471 aa)
	gcna-1	Protein CBG09024. (492 aa)
	cux-7	Protein CBR-CUX-7. (510 aa)
	CBG09882	Protein CBG09882. (235 aa)
	emb-30	Protein CBR-EMB-30. (1439 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG03465	CBG03715	A8WV48	A8WWJ1	Protein CBG03465.	Protein CBG03715.	0.529
CBG03465	CBG04254	A8WV48	A8WX21	Protein CBG03465.	Protein CBG04254.	0.593
CBG03465	CBG21521	A8WV48	A8Y0B0	Protein CBG03465.	Protein CBG21521.	0.473
CBG03465	let-858	A8WV48	A8WT19	Protein CBG03465.	Pre-mRNA-splicing factor CWC22 homolog; Required for early embryogenesis and tissue differentiation. Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity); Belongs to the CWC22 family.	0.915
CBG03465	prp-4	A8WV48	A8XF84	Protein CBG03465.	Protein CBR-PRP-4.	0.679
CBG03465	rsr-2	A8WV48	A8XYY7	Protein CBG03465.	Protein CBR-RSR-2.	0.704
CBG03715	CBG03465	A8WWJ1	A8WV48	Protein CBG03715.	Protein CBG03465.	0.529
CBG03715	CBG04254	A8WWJ1	A8WX21	Protein CBG03715.	Protein CBG04254.	0.669
CBG03715	CBG10243	A8WWJ1	A8XAS1	Protein CBG03715.	Protein CBG10243.	0.555
CBG03715	CBG14713	A8WWJ1	A8XKI3	Protein CBG03715.	Protein CBG14713.	0.438
CBG03715	CBG15138	A8WWJ1	A8XLV2	Protein CBG03715.	Protein CBG15138.	0.555
CBG03715	CBG20414	A8WWJ1	A8XXQ8	Protein CBG03715.	Protein CBG20414.	0.525
CBG03715	CBG21521	A8WWJ1	A8Y0B0	Protein CBG03715.	Protein CBG21521.	0.498
CBG03715	CBG25779	A8WWJ1	B6IGK2	Protein CBG03715.	Protein CBG25779.	0.555
CBG03715	CBG25942	A8WWJ1	B6IK74	Protein CBG03715.	Protein CBG25942.	0.624
CBG03715	cpf-2	A8WWJ1	A8WVC9	Protein CBG03715.	Protein CBR-CPF-2.	0.713
CBG03715	frg-1	A8WWJ1	A8XMS0	Protein CBG03715.	Protein CBR-FRG-1.	0.445
CBG03715	hinf-1	A8WWJ1	A8XWH9	Protein CBG03715.	Protein CBG19711.	0.497
CBG03715	let-858	A8WWJ1	A8WT19	Protein CBG03715.	Pre-mRNA-splicing factor CWC22 homolog; Required for early embryogenesis and tissue differentiation. Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity); Belongs to the CWC22 family.	0.766
CBG03715	pfs-2	A8WWJ1	A8XCF1	Protein CBG03715.	Protein CBR-PFS-2.	0.636