(46 nodes) Nuclear speck network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CBG09882	Protein CBG09882. (235 aa)
	rnp-1	Protein CBR-RNP-1. (286 aa)
	CBG25779	Protein CBG25779. (821 aa)
	nrde-2	Protein CBR-NRDE-2. (951 aa)
	uaf-1	Splicing factor U2AF 65 kDa subunit; Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity). (488 aa)
	unc-75	Protein CBR-UNC-75. (515 aa)
	CBG15138	Protein CBG15138. (300 aa)
	CBG14713	Protein CBG14713. (113 aa)
	sup-12	Protein CBR-SUP-12. (252 aa)
	pqn-37	Protein CBR-PQN-37. (562 aa)
	CBG12605	Protein CBG12605. (283 aa)
	CBG12463	Protein CBG12463. (292 aa)
	prp-4	Protein CBR-PRP-4. (496 aa)
	CBG12024	Protein CBG12024. (806 aa)
	pfs-2	Protein CBR-PFS-2. (814 aa)
	syd-9	Protein CBR-SYD-9. (429 aa)
	CBG10243	Protein CBG10243. (387 aa)
	emb-30	Protein CBR-EMB-30. (1439 aa)
	sut-2	Protein CBR-SUT-2. (722 aa)
	exc-7	Protein CBR-EXC-7. (676 aa)
	nlp-2	Protein CBR-NLP-2. (161 aa)
	let-858	Pre-mRNA-splicing factor CWC22 homolog; Required for early embryogenesis and tissue differentiation. Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity); Belongs to the CWC22 family. (935 aa)
	rsp-2	Protein CBR-RSP-2. (256 aa)
	vab-23	Protein CBR-VAB-23. (260 aa)
	rsp-5	Protein CBR-RSP-5. (150 aa)
	rsp-4	Protein CBR-RSP-4. (125 aa)
	CBG03465	Protein CBG03465. (352 aa)
	rbd-1	Protein CBR-RBD-1. (877 aa)
	rsp-3	Protein CBR-RSP-3. (258 aa)
	cpf-2	Protein CBR-CPF-2. (319 aa)
	CBG04254	Protein CBG04254. (80 aa)
	hecd-1	Protein CBR-HECD-1. (2727 aa)
	nfki-1	Protein CBG07688. (622 aa)
	rsy-1	Protein CBR-RSY-1. (579 aa)
	cux-7	Protein CBR-CUX-7. (510 aa)
	rbm-25	Protein CBG23510. (703 aa)
	ubc-3	Protein CBR-UBC-3; Belongs to the ubiquitin-conjugating enzyme family. (244 aa)
	ztf-2	Protein CBR-ZTF-2. (355 aa)
	CBG21521	Protein CBG21521. (151 aa)
	rsr-2	Protein CBR-RSR-2. (498 aa)
	CBG20414	Protein CBG20414. (335 aa)
	CBG20393	Protein CBG20393. (622 aa)
	let-756	Protein CBR-LET-756; Belongs to the heparin-binding growth factors family. (473 aa)
	CBG18142	Protein CBG18142. (1438 aa)
	rnp-4	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (142 aa)
	rsp-6	Protein CBR-RSP-6. (173 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG03465	CBG04254	A8WV48	A8WX21	Protein CBG03465.	Protein CBG04254.	0.593
CBG03465	CBG21521	A8WV48	A8Y0B0	Protein CBG03465.	Protein CBG21521.	0.473
CBG03465	let-858	A8WV48	A8WT19	Protein CBG03465.	Pre-mRNA-splicing factor CWC22 homolog; Required for early embryogenesis and tissue differentiation. Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity); Belongs to the CWC22 family.	0.915
CBG03465	prp-4	A8WV48	A8XF84	Protein CBG03465.	Protein CBR-PRP-4.	0.679
CBG03465	rsr-2	A8WV48	A8XYY7	Protein CBG03465.	Protein CBR-RSR-2.	0.704
CBG04254	CBG03465	A8WX21	A8WV48	Protein CBG04254.	Protein CBG03465.	0.593
CBG04254	CBG21521	A8WX21	A8Y0B0	Protein CBG04254.	Protein CBG21521.	0.429
CBG04254	let-858	A8WX21	A8WT19	Protein CBG04254.	Pre-mRNA-splicing factor CWC22 homolog; Required for early embryogenesis and tissue differentiation. Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity); Belongs to the CWC22 family.	0.669
CBG04254	prp-4	A8WX21	A8XF84	Protein CBG04254.	Protein CBR-PRP-4.	0.733
CBG04254	rsr-2	A8WX21	A8XYY7	Protein CBG04254.	Protein CBR-RSR-2.	0.668
CBG10243	CBG14713	A8XAS1	A8XKI3	Protein CBG10243.	Protein CBG14713.	0.778
CBG10243	CBG15138	A8XAS1	A8XLV2	Protein CBG10243.	Protein CBG15138.	0.809
CBG10243	CBG20393	A8XAS1	A8XXP0	Protein CBG10243.	Protein CBG20393.	0.470
CBG10243	CBG20414	A8XAS1	A8XXQ8	Protein CBG10243.	Protein CBG20414.	0.574
CBG10243	rbm-25	A8XAS1	A8Y3R3	Protein CBG10243.	Protein CBG23510.	0.442
CBG10243	rnp-4	A8XAS1	A8XSZ2	Protein CBG10243.	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.	0.806
CBG10243	rsp-2	A8XAS1	A8WT99	Protein CBG10243.	Protein CBR-RSP-2.	0.545
CBG10243	rsp-3	A8XAS1	A8WVC5	Protein CBG10243.	Protein CBR-RSP-3.	0.565
CBG10243	rsp-4	A8XAS1	A8WUG2	Protein CBG10243.	Protein CBR-RSP-4.	0.886
CBG10243	rsp-5	A8XAS1	A8WTS3	Protein CBG10243.	Protein CBR-RSP-5.	0.545