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| | lsm-1 | U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (125 aa) |
| | smg-8 | Protein smg-8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes (By similarity). (871 aa) |
| | hel-1 | Protein CBR-HEL-1. (424 aa) |
| | cyn-13 | Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (332 aa) |
| | gst-42 | Protein CBR-GST-42; Belongs to the GST superfamily. (215 aa) |
| | upp-1 | Protein CBG00006. (329 aa) |
| | CBG25056 | Protein CBG25056. (91 aa) |
| | CBG25054 | Protein CBG25054. (126 aa) |
| | fitm-2 | Protein CBG24962. (283 aa) |
| | CBG24565 | Protein CBG24565. (1157 aa) |
| | CBG23945 | Protein CBG23945. (91 aa) |
| | CBG23944 | Protein CBG23944. (70 aa) |
| | CBG23943 | Protein CBG23943. (82 aa) |
| | CBG23942 | Protein CBG23942. (58 aa) |
| | CBG23937 | Protein CBG23937. (86 aa) |
| | CBG23882 | Protein CBG23882. (469 aa) |
| | CBG23841 | Protein CBG23841. (717 aa) |
| | CBG23577 | Protein CBG23577. (515 aa) |
| | CBG06022 | ATP-dependent RNA helicase SUV3 homolog, mitochondrial; ATPase and DNA/RNA helicase able to unwind DNA/DNA, DNA/RNA and RNA/RNA duplexes in the 5'-3' direction. (721 aa) |
| | tbh-1 | Tyramine beta-hydroxylase; Converts tyramine into octopamine, a neurotransmitter involved in pharyngeal pumping and egg laying. (585 aa) |
| | smg-1 | Serine/threonine-protein kinase smg-1; Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating smg-2 (By similarity); Belongs to the PI3/PI4-kinase family. (2313 aa) |
| | mig-23 | Nucleoside-diphosphatase mig-23; Seems to be able to hydrolyze ADP, UDP and GDP. Supports mig- 17 glycosylation and surface expression, which is required for proper migration of distal tip cells during gonad morphogenesis (By similarity). (553 aa) |
| | hpd-1 | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. (393 aa) |
| | haao-1 | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (281 aa) |
| | xrn-2 | 5'-3' exoribonuclease 2 homolog; Possesses 5'->3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Degradation role is enhanced when in complex with paxt-1. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle. (976 aa) |
| | ccf-1 | Protein CBG13315. (315 aa) |
| | CBG27615 | Protein CBG27615. (78 aa) |
| | CBG25377 | Protein CBG25377; Belongs to the PI3/PI4-kinase family. (916 aa) |
| | mrpl-44 | Protein CBG26009. (346 aa) |
| | CBG23101 | Protein CBG23101. (681 aa) |
| | ccch-1 | Protein CBG23235. (417 aa) |
| | pqn-53 | Protein CBR-PQN-53. (348 aa) |
| | kmo-1 | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (461 aa) |
| | CBG22975 | Protein CBG22975. (146 aa) |
| | dcr-1 | Protein CBR-DCR-1; Belongs to the helicase family. Dicer subfamily. (2030 aa) |
| | cdd-1 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (158 aa) |
| | ain-2 | Protein CBR-AIN-2. (762 aa) |
| | lin-41 | Protein CBR-LIN-41. (934 aa) |
| | hint-1 | Protein CBR-HINT-1. (130 aa) |
| | cpin-1 | Protein CBR-CPIN-1. (424 aa) |
| | prp-19 | Protein CBG21324. (492 aa) |
| | hap-1 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (184 aa) |
| | Cbr-rnh-1.3 | Protein CBR-RNH-1.3. (150 aa) |
| | xrn-1 | 5'-3' exoribonuclease 1. (1644 aa) |
| | CBG20808 | Protein CBG20808. (467 aa) |
| | rnh-1.0.2 | Protein CBG20622. (156 aa) |
| | CBG20393 | Protein CBG20393. (622 aa) |
| | CBG20309 | Protein CBG20309; Belongs to the GST superfamily. (223 aa) |
| | pelo-1 | Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (382 aa) |
| | CBG19806 | Protein CBG19806. (229 aa) |
| | CBG19432 | Protein CBG19432; Belongs to the GDA1/CD39 NTPase family. (216 aa) |
| | CBG19371 | Protein CBG19371. (462 aa) |
| | Cbr-tag-153 | Protein CBR-TAG-153. (760 aa) |
| | CBG19000 | Protein CBG19000. (398 aa) |
| | CBG18950 | Epoxide hydrolase. (453 aa) |
| | CBG18681 | Protein CBG18681. (217 aa) |
| | mag-1 | Protein CBR-MAG-1. (153 aa) |
| | rnp-4 | RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (142 aa) |
| | mlcd-1 | Protein CBG18041. (442 aa) |
| | pde-12 | Protein CBG18301. (651 aa) |
| | rle-1 | Protein CBR-RLE-1. (1001 aa) |
| | CBG18226 | Protein CBG18226. (168 aa) |
| | ntl-9 | Protein CBR-NTL-9. (314 aa) |
| | CBG17907 | Protein CBG17907. (223 aa) |
| | rnst-2 | Protein CBG17875; Belongs to the RNase T2 family. (243 aa) |
| | ntp-1 | Protein CBR-NTP-1; Belongs to the GDA1/CD39 NTPase family. (511 aa) |
| | apy-1 | Protein CBG16731. (354 aa) |
| | exos-9 | Protein CBR-EXOS-9. (434 aa) |
| | panl-2 | Protein CBG16490. (1149 aa) |
| | crn-7 | Protein CBR-CRN-7. (367 aa) |
| | let-711 | Protein CBR-LET-711. (2627 aa) |
| | CBG16435 | Protein CBG16435. (293 aa) |
| | ain-1 | Protein CBR-AIN-1. (712 aa) |
| | CBG15689 | Protein CBG15689. (192 aa) |
| | smg-6 | Protein CBR-SMG-6. (773 aa) |
| | CBG15142 | Protein CBG15142. (802 aa) |
| | grk-2 | Protein CBR-GRK-2. (377 aa) |
| | CBG15102 | Protein CBG15102; Belongs to the Nudix hydrolase family. (253 aa) |
| | edc-4 | Protein CBG14967. (841 aa) |
| | crn-1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa) |
| | flu-2 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (483 aa) |
| | puf-9 | Protein CBR-PUF-9. (698 aa) |
| | CBG14622 | Protein CBG14622. (380 aa) |
| | crn-4 | Protein CBG14050. (210 aa) |
| | Cbr-crn-4 | Protein CBR-CRN-4. (298 aa) |
| | CBG14047 | Protein CBG14047. (298 aa) |
| | ntl-11 | Protein CBG13718. (798 aa) |
| | ndx-4 | Protein CBR-NDX-4. (137 aa) |
| | eri-1 | Protein CBR-ERI-1. (578 aa) |
| | dis-3 | Protein CBR-DIS-3; Belongs to the RNR ribonuclease family. (979 aa) |
| | wah-1 | Protein CBR-WAH-1. (696 aa) |
| | CBG13329 | Protein CBG13329. (416 aa) |
| | ntl-3 | Protein CBR-NTL-3. (727 aa) |
| | rpb-4 | Protein CBR-RPB-4. (144 aa) |
| | CBG13069 | Protein CBG13069. (111 aa) |
| | CBG13068 | Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (220 aa) |
| | rnh-1.1 | Protein CBR-RNH-1.1. (519 aa) |
| | pde-4 | Phosphodiesterase. (785 aa) |
| | dcs-1 | Protein CBR-DCS-1. (312 aa) |
| | ahcy-1 | Adenosylhomocysteinase. (437 aa) |
| | ncbp-1 | Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-1 does not bind directly capped RNAs (m7GpppG- capped RNA) but is required to stabilize the movement of the N-terminal loop of ncbp-2 and lock the CBC into a high affinity cap-binding state with the c [...] (793 aa) |
| | edc-3 | Protein CBR-EDC-3. (557 aa) |
| | CBG12828 | Protein CBG12828. (323 aa) |
| | hgo-1 | Protein CBR-HGO-1. (445 aa) |
| | nth-1 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (289 aa) |
| | poml-2 | Protein CBG12060. (367 aa) |
| | poml-4 | Protein CBG12059. (365 aa) |
| | uda-1 | Protein CBR-UDA-1; Belongs to the GDA1/CD39 NTPase family. (304 aa) |
| | CBG11411 | Protein CBG11411. (290 aa) |
| | CBG11412 | Protein CBG11412. (349 aa) |
| | eol-1 | Protein CBG11414. (281 aa) |
| | CBG11415 | Protein CBG11415. (320 aa) |
| | CBG11134 | Protein CBG11134. (300 aa) |
| | exos-8 | Protein CBR-EXOS-8. (361 aa) |
| | CBG10483 | Protein CBG10483. (558 aa) |
| | CBG09744 | Protein CBG09744. (65 aa) |
| | rnh-1.0.1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (266 aa) |
| | crn-6 | Protein CBR-CRN-6. (380 aa) |
| | panl-3 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (642 aa) |
| | crn-2 | Protein CBR-CRN-2. (300 aa) |
| | CBG09540 | Protein CBG09540. (561 aa) |
| | CBG09200 | Protein CBG09200. (187 aa) |
| | CBG09201 | Protein CBG09201. (110 aa) |
| | CBG09150 | Protein CBG09150. (153 aa) |
| | tdo-2 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety (By similarity). Involved in regulation of protein homeostasis, longevity and reproducive life span. Specifically regulates proteotoxicity due to age-related aggregation of proteins like alpha-synuclein, via its effects on tryptophan metabolism (By similarity). (404 aa) |
| | ndx-1 | Protein CBR-NDX-1; Belongs to the Nudix hydrolase family. (350 aa) |
| | parn-1 | Protein CBG08556. (556 aa) |
| | ttc-37 | Protein CBG08701. (1107 aa) |
| | smg-2 | Protein CBR-SMG-2. (1051 aa) |
| | dcap-1 | Protein CBR-DCAP-1. (340 aa) |
| | smgl-2 | Protein CBR-SMGL-2. (1021 aa) |
| | smgl-1 | Protein CBR-SMGL-1. (1627 aa) |
| | ndx-8 | Protein CBR-NDX-8. (327 aa) |
| | tiar-2 | Protein CBR-TIAR-2. (411 aa) |
| | pqn-39 | Protein CBR-PQN-39. (758 aa) |
| | poml-1 | Protein CBG07381. (371 aa) |
| | tatn-1 | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (466 aa) |
| | qdpr-1 | Protein CBR-QDPR-1. (236 aa) |
| | pde-2 | Phosphodiesterase. (959 aa) |
| | CBG06449 | Protein CBG06449. (462 aa) |
| | CBG05749 | Protein CBG05749. (407 aa) |
| | CBG05751 | Protein CBG05751. (360 aa) |
| | afmd-1 | Protein CBG05817. (216 aa) |
| | cdd-2 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (166 aa) |
| | ndx-9 | Protein CBR-NDX-9. (348 aa) |
| | alh-3 | 10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa) |
| | skih-2 | Protein CBR-SKIH-2. (1286 aa) |
| | CBG06073 | Protein CBG06073. (146 aa) |
| | exos-7 | Protein CBR-EXOS-7. (307 aa) |
| | smg-3 | Protein CBR-SMG-3. (1141 aa) |
| | exos-2 | Protein CBR-EXOS-2. (305 aa) |
| | disl-2 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. (841 aa) |
| | eme-1 | Protein CBG05147. (430 aa) |
| | fah-1 | Fumarylacetoacetase. (418 aa) |
| | rnh-2 | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (297 aa) |
| | tsn-1 | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (913 aa) |
| | smg-9 | Protein smg-9; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes (By similarity). (382 aa) |
| | lem-3 | Protein CBR-LEM-3. (698 aa) |
| | dut-1 | Protein CBR-DUT-1. (487 aa) |
| | rpb-7 | Protein CBR-RPB-7. (174 aa) |
| | smg-5 | Protein CBR-SMG-5. (551 aa) |
| | CBG04018 | Protein CBG04018; Belongs to the DEAD box helicase family. (393 aa) |
| | cps-6 | Endonuclease. (310 aa) |
| | ntl-2 | Protein CBR-NTL-2. (491 aa) |
| | CBG03616 | Protein CBG03616. (379 aa) |
| | tir-1 | Protein CBR-TIR-1. (585 aa) |
| | CBG03609 | Protein CBG03609. (174 aa) |
| | CBG03606 | Protein CBG03606. (414 aa) |
| | mtr-4 | Protein CBR-MTR-4. (1024 aa) |
| | ccr-4 | Protein CBR-CCR-4. (781 aa) |
| | ndx-3 | Protein CBR-NDX-3. (241 aa) |
| | CBG02379 | Protein CBG02379. (303 aa) |
| | CBG02420 | Protein CBG02420. (564 aa) |
| | tiar-1 | Protein CBR-TIAR-1. (403 aa) |
| | CBG02610 | Protein CBG02610. (381 aa) |
| | moe-3 | Protein CBR-MOE-3. (377 aa) |
| | CBG01454 | Protein CBG01454. (636 aa) |
| | crn-5 | Protein CBR-CRN-5. (214 aa) |
| | crn-3 | Protein CBR-CRN-3. (868 aa) |
| | CBG03113 | Protein CBG03113. (665 aa) |
| | patr-1 | Protein PAT1 homolog 1; RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery (By similarity); Belongs to the PAT1 family. (864 aa) |
| | CBG03126 | Protein CBG03126. (72 aa) |
| | pah-1 | Protein CBR-PAH-1. (458 aa) |
| | CBG03179 | Protein CBG03179. (330 aa) |
| | exos-3 | Protein CBR-EXOS-3. (226 aa) |
| | CBG02010 | Protein CBG02010. (300 aa) |
| | dcap-2 | Protein CBR-DCAP-2. (762 aa) |
| | afmd-2 | Protein CBG01758. (266 aa) |
| | exos-4.1 | Putative exosome complex component RRP41; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. (240 aa) |
