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| | rpn-2 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (970 aa) |
| | goa-1 | Protein CBR-GOA-1. (323 aa) |
| | Cbr-mel-11 | Protein CBG24954. (336 aa) |
| | ensh-1 | Protein CBG00249. (497 aa) |
| | hsp-75 | Protein CBG00585. (672 aa) |
| | aakg-5 | Protein CBR-AAKG-5. (476 aa) |
| | sec-5 | Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (886 aa) |
| | mel-11 | Protein CBR-MEL-11. (1167 aa) |
| | fbxa-137 | Protein CBR-FBXA-137. (321 aa) |
| | tpa-1 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (705 aa) |
| | pmk-3 | Mitogen-activated protein kinase. (466 aa) |
| | aakg-3 | Protein CBR-AAKG-3. (398 aa) |
| | aakg-4 | Protein CBR-AAKG-4. (461 aa) |
| | CBG03180 | Protein CBG03180. (451 aa) |
| | mak-1 | Protein CBG03152. (529 aa) |
| | CBG03052 | Protein CBG03052. (74 aa) |
| | ccm-3 | Protein CBG03050. (215 aa) |
| | Cbr-max-2 | Protein CBR-MAX-2; Belongs to the protein kinase superfamily. (422 aa) |
| | max-2 | Protein CBG02801. (317 aa) |
| | dsh-1 | Protein CBR-DSH-1. (1129 aa) |
| | golg-2 | Protein CBG02303. (941 aa) |
| | nsy-1 | Protein CBR-NSY-1. (1577 aa) |
| | CBG03383 | Protein CBG03383. (567 aa) |
| | rack-1 | Protein CBR-RACK-1. (325 aa) |
| | egl-20 | Protein CBR-EGL-20. (398 aa) |
| | wdfy-3 | Protein CBG03484. (3387 aa) |
| | CBG03606 | Protein CBG03606. (414 aa) |
| | CBG03609 | Protein CBG03609. (174 aa) |
| | tir-1 | Protein CBR-TIR-1. (585 aa) |
| | CBG03616 | Protein CBG03616. (379 aa) |
| | lin-17 | Protein CBR-LIN-17; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa) |
| | pop-1 | Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage- derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. Belongs t [...] (439 aa) |
| | tpxl-1 | Protein CBR-TPXL-1. (452 aa) |
| | yap-1 | Protein CBG04520. (425 aa) |
| | cdf-1 | Protein CBR-CDF-1. (545 aa) |
| | shc-1 | Protein CBR-SHC-1. (317 aa) |
| | zen-4 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (779 aa) |
| | cyb-3 | Protein CBR-CYB-3; Belongs to the cyclin family. (386 aa) |
| | num-1 | Protein CBR-NUM-1. (636 aa) |
| | gck-3 | Protein CBR-GCK-3. (596 aa) |
| | unc-22 | Protein CBR-UNC-22. (7455 aa) |
| | let-60 | Protein CBR-LET-60. (184 aa) |
| | sqst-2 | Protein CBG05836. (237 aa) |
| | egl-2 | Protein CBR-EGL-2. (950 aa) |
| | rog-1 | Protein CBR-ROG-1. (661 aa) |
| | jip-1 | Protein CBR-JIP-1. (385 aa) |
| | CBG07104 | Protein CBG07104. (529 aa) |
| | CBG07019 | Protein CBG07019. (346 aa) |
| | cwn-1 | Protein CBR-CWN-1. (372 aa) |
| | nipi-3 | Protein CBR-NIPI-3. (650 aa) |
| | tap-1 | Protein CBR-TAP-1. (389 aa) |
| | aakb-1 | Protein CBR-AAKB-1. (268 aa) |
| | sli-1 | Protein CBR-SLI-1. (546 aa) |
| | cdc-48.3 | Protein CBR-CDC-48.3. (736 aa) |
| | nmy-2 | Protein CBR-NMY-2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2051 aa) |
| | mlk-1 | Protein CBR-MLK-1. (1091 aa) |
| | par-6 | Protein CBR-PAR-6. (305 aa) |
| | wrm-1 | Armadillo repeat-containing protein wrm-1; Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1- dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome [...] (799 aa) |
| | abi-1 | Protein CBR-ABI-1. (487 aa) |
| | crp-1 | Protein CBR-CRP-1. (187 aa) |
| | CBG09813 | Protein CBG09813. (933 aa) |
| | cdk-1 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). (326 aa) |
| | unc-16 | Protein CBR-UNC-16. (1158 aa) |
| | CBG10577 | Protein CBG10577. (183 aa) |
| | CBG10568 | Protein CBG10568. (36 aa) |
| | epg-9 | Protein CBG10567. (209 aa) |
| | aap-1 | Protein CBR-AAP-1. (522 aa) |
| | CBG10973 | Protein CBG10973. (372 aa) |
| | CBG10974 | Protein CBG10974. (318 aa) |
| | ist-1 | Protein CBR-IST-1. (1258 aa) |
| | CBG11004 | Protein CBG11004. (576 aa) |
| | epg-7 | Protein CBR-ATG-11. (1313 aa) |
| | svh-2 | Protein CBG10839; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1120 aa) |
| | mom-2 | Protein CBR-MOM-2. (358 aa) |
| | aakg-1 | Protein CBG11682. (519 aa) |
| | CBG11789 | Protein CBG11789. (244 aa) |
| | glh-4 | Protein CBR-GLH-4. (1192 aa) |
| | mex-5 | Protein CBR-MEX-5. (474 aa) |
| | egg-4 | Protein CBR-EGG-4. (752 aa) |
| | CBG12081 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (105 aa) |
| | unc-15 | Protein CBR-UNC-15. (872 aa) |
| | mel-26 | Protein CBR-MEL-26. (394 aa) |
| | glh-1 | Protein CBR-GLH-1. (817 aa) |
| | axl-1 | Axin-like protein 1; Works in parallel with pry-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Shown to have a role in excretory cell development (By similarity). (395 aa) |
| | CBG12570 | Protein CBG12570. (1945 aa) |
| | aakb-2 | Protein CBR-AAKB-2. (273 aa) |
| | ced-2 | Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Also has a role in the migration of the 2 gonadal distal tip cells (DTCs) (By similarity). Belongs to the CRK family. (277 aa) |
| | rho-1 | Protein CBR-RHO-1. (192 aa) |
| | CBG13699 | Protein CBG13699. (277 aa) |
| | mak-2 | Protein CBR-MAK-2; Belongs to the protein kinase superfamily. (366 aa) |
| | jtr-1 | Protein CBR-JTR-1. (133 aa) |
| | ubxn-2 | Protein CBR-UBXN-2. (702 aa) |
| | nck-1 | Protein CBR-NCK-1. (393 aa) |
| | CBG14707 | Protein CBG14707. (591 aa) |
| | kin-2 | Protein CBR-KIN-2. (366 aa) |
| | ced-10 | Protein CBG15031. (191 aa) |
| | CBG15098 | Protein CBG15098. (583 aa) |
| | CBG15099 | Protein CBG15099. (1088 aa) |
| | CBG15268 | Protein CBG15268. (765 aa) |
| | par-2 | Protein CBR-PAR-2. (647 aa) |
| | CBG15339 | Protein CBG15339. (331 aa) |
| | cks-1 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. Has a role in the exit from M phase during early mitotic cell division. More specifically, thought to act by the degrading B-type cyclins that causes breakdown of nuclear envelope and exit mitosis (By similarity). (94 aa) |
| | CBG15645 | Protein CBG15645. (840 aa) |
| | ppm-1.d | Protein CBG15663. (749 aa) |
| | daf-2 | Protein CBR-DAF-2. (1840 aa) |
| | CBG16425 | Protein CBG16425. (528 aa) |
| | CBG16422 | Protein CBG16422. (1450 aa) |
| | CBG16414 | Protein CBG16414. (581 aa) |
| | aakg-2 | Protein CBR-AAKG-2. (425 aa) |
| | lyst-1 | Protein CBG16224. (2802 aa) |
| | CBG16567 | Protein CBG16567. (170 aa) |
| | CBG16744 | Protein CBG16744. (663 aa) |
| | sek-1 | Protein CBR-SEK-1; Belongs to the protein kinase superfamily. (352 aa) |
| | mig-2 | Protein CBR-MIG-2. (195 aa) |
| | CBG17614 | Protein CBG17614. (132 aa) |
| | CBG17612 | Protein CBG17612. (380 aa) |
| | strd-1 | Protein CBR-STRD-1. (385 aa) |
| | hpr-9 | Protein CBR-HPR-9. (513 aa) |
| | CBG17958 | Protein CBG17958. (239 aa) |
| | cdka-1 | Cyclin-dependent kinase 5 activator. (366 aa) |
| | sel-2 | Putative neurobeachin homolog; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Regulates endosomal traffic in polarized epithelial cells such as the vulval precursor cells and intestinal cells. Thought to act as a negative regulator of lin-12 activity in vulval precursor cells. May have a role in the internalization process from basolateral surface of polarized epithelial cells (By similarity). (2531 aa) |
| | atf-7 | Protein CBR-ATF-7. (519 aa) |
| | cyy-1 | Protein CBR-CYY-1; Belongs to the cyclin family. (357 aa) |
| | pry-1 | Axin-like protein pry-1; Works in parallel with axl-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Inhibits Wnt signaling, which affects tissue specific expression of Hox genes, egl- 5, lin-39 and mab-5. This in turn affects QR (postembryonic neuroblast) cell migration, vulval cell fate specification, and the development of sensory structures by the seam cell lineage. Has a role in alae V cell patterning, ray formation in the male tail and axon guidance. Does not affect B cell polarity (By similarity). (625 aa) |
| | CBG19101 | Protein CBG19101. (318 aa) |
| | gck-1 | Protein CBR-GCK-1. (898 aa) |
| | mdf-1 | Protein CBR-MDF-1. (681 aa) |
| | CBG19566 | Protein CBG19566. (337 aa) |
| | let-756 | Protein CBR-LET-756; Belongs to the heparin-binding growth factors family. (473 aa) |
| | hmp-2 | Protein CBR-HMP-2. (686 aa) |
| | unc-5 | Protein CBR-UNC-5. (922 aa) |
| | CBG20111 | Protein CBG20111; Belongs to the CGI121/TPRKB family. (183 aa) |
| | CBG20115 | Protein CBG20115. (361 aa) |
| | egg-3 | Protein CBR-EGG-3. (419 aa) |
| | CBG20695 | Protein CBG20695. (93 aa) |
| | spat-1 | Protein CBR-SPAT-1. (542 aa) |
| | CBG21499 | Protein CBG21499. (446 aa) |
| | unc-14 | Protein CBR-UNC-14. (666 aa) |
| | gap-3 | Protein CBG22075. (960 aa) |
| | ksr-1 | Protein CBR-KSR-1. (812 aa) |
| | pptr-1 | Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (531 aa) |
| | CBG27393 | Protein CBG27393. (341 aa) |
| | CBG25881 | Protein CBG25881. (157 aa) |
| | CBG14590 | Protein CBG14590. (434 aa) |
| | gcn-1 | Protein CBG15647. (906 aa) |
| | CBG23879 | Protein CBG23879. (272 aa) |
| | spd-2 | Spindle-defective protein 2; Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment. (829 aa) |
| | sel-10 | F-box/WD repeat-containing protein sel-10; Probable substrate recognition component of SCF (SKP1-CUL-F- box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates synapse elimination in early development in the motor neuron HSNL. Cell autonomous negative regulator of lin-12/Notch- mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis. May target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation. Involved in sex determi [...] (589 aa) |
