STRINGSTRING
CBG10541 CBG10541 cor-1 cor-1 arx-4 arx-4 alp-1 alp-1 CBG24443 CBG24443 CBG24444 CBG24444 CBG24445 CBG24445 stn-1 stn-1 CBG00040 CBG00040 Cbr-myo-2 Cbr-myo-2 fli-1 fli-1 CBG01035 CBG01035 irld-30 irld-30 fbxa-137 fbxa-137 ced-3 ced-3 CBG01565 CBG01565 wsp-1 wsp-1 ipla-2 ipla-2 syg-1 syg-1 CBG02162 CBG02162 CBG02167 CBG02167 CBG03266 CBG03266 CBG03137 CBG03137 cap-2 cap-2 saps-1 saps-1 rsf-1 rsf-1 ani-2 ani-2 ddl-1 ddl-1 gex-3 gex-3 hum-7 hum-7 unc-94 unc-94 CBG03927 CBG03927 CBG03928 CBG03928 viln-1 viln-1 let-502 let-502 mei-1 mei-1 arx-7 arx-7 CBG03746 CBG03746 CBG03790 CBG03790 egl-1 egl-1 CBG04771 CBG04771 mup-2 mup-2 cutl-20 cutl-20 osg-1.2 osg-1.2 osg-1.1 osg-1.1 ipla-3 ipla-3 CBG06095 CBG06095 valv-1 valv-1 unc-82 unc-82 CBG05862 CBG05862 cap-1 cap-1 rga-4 rga-4 cul-3 cul-3 daam-1 daam-1 CBG06442 CBG06442 unc-60 unc-60 CBG06638 CBG06638 cutl-1 cutl-1 CBG06875 CBG06875 dyc-1 dyc-1 CBG07250 CBG07250 pfn-3 pfn-3 lgl-1 lgl-1 pha-2 pha-2 unc-96 unc-96 CBG08444 CBG08444 CBG08665 CBG08665 frm-1 frm-1 mlp-1 mlp-1 frm-2 frm-2 abi-1 abi-1 chw-1 chw-1 crp-1 crp-1 unc-44.2 unc-44.2 unc-44.1 unc-44.1 pph-6 pph-6 chc-1 chc-1 set-27 set-27 gei-1 gei-1 fozi-1 fozi-1 fln-1 fln-1 bris-1 bris-1 pat-10 pat-10 CBG10797 CBG10797 fhod-1 fhod-1 unc-6 unc-6 unc-52 unc-52 myo-5 myo-5 tmd-2 tmd-2 CBG11256 CBG11256 ani-1 ani-1 egg-4 egg-4 unc-89 unc-89 unc-73 unc-73 nab-1 nab-1 unc-15 unc-15 tnt-4 tnt-4 ced-12 ced-12 hum-1 hum-1 mel-26 mel-26 CBG12470 CBG12470 frm-4 frm-4 erm-1 erm-1 CBG12887 CBG12887 chn-1 chn-1 CBG12554 CBG12554 CBG12665 CBG12665 unc-87 unc-87 slo-1 slo-1 cdc-42 cdc-42 CBG13452 CBG13452 hum-8 hum-8 ced-2 ced-2 rho-1 rho-1 CBG13699 CBG13699 eps-8 eps-8 plst-1 plst-1 spc-1 spc-1 unc-78 unc-78 CBG14574 CBG14574 pqn-62 pqn-62 CBG14672 CBG14672 CBG14863 CBG14863 cdap-2 cdap-2 unc-33 unc-33 ced-10 ced-10 nmy-3 nmy-3 unc-45 unc-45 exc-6 exc-6 pod-1 pod-1 hipr-1 hipr-1 dys-1 dys-1 Cbr-dys-1 Cbr-dys-1 unc-27 unc-27 tnt-2 tnt-2 frl-1 frl-1 arx-5 arx-5 frg-1 frg-1 Cbr-pat-4 Cbr-pat-4 ced-1 ced-1 CBG16073 CBG16073 CBG16381 CBG16381 twf-2 twf-2 CBG16347 CBG16347 cas-1 cas-1 fln-2 fln-2 Cbr-fln-2.1 Cbr-fln-2.1 cyk-1 cyk-1 viro-2 viro-2 tnt-3 tnt-3 mig-2 mig-2 hum-4 hum-4 Cbr-exc-9 Cbr-exc-9 dbn-1 dbn-1 CBG18400 CBG18400 CBG17945 CBG17945 arx-6 arx-6 arx-3 arx-3 wve-1 wve-1 mrck-1 mrck-1 unc-70 unc-70 ttc-17 ttc-17 hum-2 hum-2 gsnl-1 gsnl-1 ehbp-1 ehbp-1 CBG19348 CBG19348 CBG19471 CBG19471 CBG19457 CBG19457 CBG19533 CBG19533 CBG19647 CBG19647 zoo-1 zoo-1 hmp-2 hmp-2 unc-54 unc-54 unc-5 unc-5 CBG20121 CBG20121 hum-5 hum-5 CBG20238 CBG20238 cpn-4 cpn-4 CBG20438 CBG20438 vab-19 vab-19 egg-3 egg-3 ddl-2 ddl-2 CBG21023 CBG21023 myo-6 myo-6 CBG21188 CBG21188 CBG21334 CBG21334 CBG21573 CBG21573 Cbr-tag-273 Cbr-tag-273 CBG21760 CBG21760 myo-1 myo-1 spe-15 spe-15 dyb-1 dyb-1 CBG22322 CBG22322 sorb-1 sorb-1 CBG22502 CBG22502 pat-6 pat-6 aipl-1 aipl-1 tth-1 tth-1 atn-1 atn-1 hmp-1 hmp-1 act-2 act-2 act-4 act-4 inft-2 inft-2 CBG11409 CBG11409 CBG25604 CBG25604 CBG27374 CBG27374 CBG27110 CBG27110 CBG25881 CBG25881 CBG25883 CBG25883 CBG26587 CBG26587 Cbr-fozi-1 Cbr-fozi-1 CBG25215 CBG25215 CBG26279 CBG26279 CBG27527 CBG27527 CBG26242 CBG26242 CBG14590 CBG14590 CBG16668 CBG16668 CBG27040 CBG27040 CBG25001 CBG25001 unc-53 unc-53 CBG29119 CBG29119 myo-3 myo-3 lev-11 lev-11 ced-4 ced-4 unc-98 unc-98 arx-2 arx-2 arx-1 arx-1 hum-6 hum-6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBG10541Protein CBG10541. (1363 aa)
cor-1Coronin; Belongs to the WD repeat coronin family. (602 aa)
arx-4Protein CBR-ARX-4. (539 aa)
alp-1Protein CBR-ALP-1. (2170 aa)
CBG24443Protein CBG24443. (93 aa)
CBG24444Protein CBG24444. (376 aa)
CBG24445Protein CBG24445. (368 aa)
stn-1Protein CBR-STN-1. (422 aa)
CBG00040Protein CBG00040. (1622 aa)
Cbr-myo-2Protein CBR-MYO-2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2009 aa)
fli-1Protein CBR-FLI-1. (1271 aa)
CBG01035Protein CBG01035. (422 aa)
irld-30Protein CBG01133. (405 aa)
fbxa-137Protein CBR-FBXA-137. (321 aa)
ced-3Protein CBR-CED-3; Belongs to the peptidase C14A family. (508 aa)
CBG01565Protein CBG01565. (188 aa)
wsp-1Protein CBR-WSP-1. (785 aa)
ipla-2Protein CBG01902. (1072 aa)
syg-1Protein CBR-SYG-1. (746 aa)
CBG02162Protein CBG02162. (372 aa)
CBG02167Protein CBG02167. (372 aa)
CBG03266Protein CBG03266. (318 aa)
CBG03137Protein CBG03137. (242 aa)
cap-2F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (271 aa)
saps-1Protein CBR-SAPS-1. (782 aa)
rsf-1Protein CBG02930. (606 aa)
ani-2Protein CBR-ANI-2. (1038 aa)
ddl-1Protein CBR-DDL-1. (206 aa)
gex-3Protein CBR-GEX-3. (1140 aa)
hum-7Protein CBR-HUM-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1886 aa)
unc-94Protein CBR-UNC-94. (406 aa)
CBG03927Protein CBG03927. (280 aa)
CBG03928Protein CBG03928. (325 aa)
viln-1Protein CBG03958. (901 aa)
let-502Rho-associated protein kinase let-502; Negatively regulates mel-11 to relieve the inhibition of mlc- 4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization (By similarity). (1194 aa)
mei-1Meiotic spindle formation protein mei-1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays. This activity may promote rapid reorganization of cellular microtubule arrays. Required specifically for meiotic spindle formation in the female germline; the presence of this protein is inimical to the formation of mitotic spindles. (484 aa)
arx-7Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (152 aa)
CBG03746Protein CBG03746. (495 aa)
CBG03790Protein CBG03790. (973 aa)
egl-1Protein CBR-EGL-1. (110 aa)
CBG04771Protein CBG04771. (1325 aa)
mup-2Protein CBR-MUP-2. (421 aa)
cutl-20Protein CBG05129. (310 aa)
osg-1.2Protein CBG05206. (647 aa)
osg-1.1Protein CBG05214. (623 aa)
ipla-3Protein CBG05582. (1062 aa)
CBG06095Protein CBG06095. (509 aa)
valv-1Protein CBR-VALV-1. (84 aa)
unc-82Protein CBR-UNC-82. (1723 aa)
CBG05862Protein CBG05862. (257 aa)
cap-1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (282 aa)
rga-4Protein CBR-RGA-4. (1095 aa)
cul-3Protein CBR-CUL-3; Belongs to the cullin family. (810 aa)
daam-1Protein CBR-DAAM-1. (862 aa)
CBG06442Protein CBG06442. (210 aa)
unc-60Protein CBR-UNC-60; Belongs to the actin-binding proteins ADF family. (293 aa)
CBG06638Protein CBG06638. (771 aa)
cutl-1Protein CBG06722. (365 aa)
CBG06875Protein CBG06875. (310 aa)
dyc-1Protein CBR-DYC-1. (985 aa)
CBG07250Protein CBG07250. (495 aa)
pfn-3Profilin; Belongs to the profilin family. (114 aa)
lgl-1Protein CBR-LGL-1. (969 aa)
pha-2Protein CBR-PHA-2. (211 aa)
unc-96Protein CBR-UNC-96. (404 aa)
CBG08444Protein CBG08444. (213 aa)
CBG08665Protein CBG08665. (302 aa)
frm-1Protein CBR-FRM-1. (6473 aa)
mlp-1Protein CBR-MLP-1. (113 aa)
frm-2Protein CBR-FRM-2. (590 aa)
abi-1Protein CBR-ABI-1. (487 aa)
chw-1Protein CBR-CHW-1. (207 aa)
crp-1Protein CBR-CRP-1. (187 aa)
unc-44.2Protein CBG09473. (5237 aa)
unc-44.1Protein CBG09456. (1857 aa)
pph-6Serine/threonine-protein phosphatase. (330 aa)
chc-1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1660 aa)
set-27Protein CBR-SET-27. (483 aa)
gei-1Protein CBR-GEI-1. (645 aa)
fozi-1Protein CBR-FOZI-1. (688 aa)
fln-1Protein CBG10542. (1091 aa)
bris-1Protein CBG10729. (621 aa)
pat-10Protein CBR-PAT-10. (161 aa)
CBG10797Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (215 aa)
fhod-1Protein CBR-FHOD-1. (1059 aa)
unc-6Protein CBR-UNC-6. (621 aa)
unc-52Protein CBR-UNC-52. (2481 aa)
myo-5Protein CBR-MYO-5; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
tmd-2Protein CBR-TMD-2. (641 aa)
CBG11256Protein CBG11256. (254 aa)
ani-1Protein CBR-ANI-1. (1199 aa)
egg-4Protein CBR-EGG-4. (752 aa)
unc-89Protein CBR-UNC-89. (6561 aa)
unc-73Protein CBR-UNC-73. (1618 aa)
nab-1Protein CBR-NAB-1. (742 aa)
unc-15Protein CBR-UNC-15. (872 aa)
tnt-4Protein CBR-TNT-4. (308 aa)
ced-12Cell death abnormality protein 12; Involved in apoptosis and necrosis. Required for the cell corpse engulfment process. Has roles in the formation of actin halos and distal tip cell migration. Plays no role in amphid axon outgrowth (By similarity). (740 aa)
hum-1Protein CBR-HUM-1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1131 aa)
mel-26Protein CBR-MEL-26. (394 aa)
CBG12470Protein CBG12470. (171 aa)
frm-4Protein CBR-FRM-4. (706 aa)
erm-1Protein CBR-ERM-1. (563 aa)
CBG12887Protein CBG12887. (133 aa)
chn-1Protein CBR-CHN-1. (266 aa)
CBG12554Protein CBG12554. (1040 aa)
CBG12665Protein CBG12665. (236 aa)
unc-87Protein CBR-UNC-87. (547 aa)
slo-1Protein CBR-SLO-1. (1165 aa)
cdc-42Protein CBR-CDC-42. (191 aa)
CBG13452Protein CBG13452. (192 aa)
hum-8Protein CBR-HUM-8; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1327 aa)
ced-2Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Also has a role in the migration of the 2 gonadal distal tip cells (DTCs) (By similarity). Belongs to the CRK family. (277 aa)
rho-1Protein CBR-RHO-1. (192 aa)
CBG13699Protein CBG13699. (277 aa)
eps-8Protein CBR-EPS-8. (918 aa)
plst-1Protein CBR-PLST-1. (623 aa)
spc-1Protein CBR-SPC-1. (2467 aa)
unc-78Protein CBR-UNC-78. (611 aa)
CBG14574Protein CBG14574. (324 aa)
pqn-62Protein CBR-PQN-62. (1344 aa)
CBG14672Profilin; Belongs to the profilin family. (131 aa)
CBG14863Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa)
cdap-2Protein CBG14969. (544 aa)
unc-33Protein CBR-UNC-33. (862 aa)
ced-10Protein CBG15031. (191 aa)
nmy-3Protein CBG15043; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1526 aa)
unc-45Protein CBR-UNC-45. (961 aa)
exc-6Protein CBR-INFT-1. (901 aa)
pod-1Protein CBR-POD-1. (1118 aa)
hipr-1Protein CBR-HIPR-1. (931 aa)
dys-1Protein CBG15371. (1276 aa)
Cbr-dys-1Protein CBR-DYS-1. (2353 aa)
unc-27Protein CBR-UNC-27. (238 aa)
tnt-2Protein CBR-TNT-2. (426 aa)
frl-1Protein CBR-FRL-1. (1175 aa)
arx-5Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa)
frg-1Protein CBR-FRG-1. (281 aa)
Cbr-pat-4Protein CBR-PAT-4. (278 aa)
ced-1Cell death abnormality protein 1; Involved in programmed cell death/apoptosis. Acts by recruiting ced-6 to phagosomes which enables actin-dependent cytoskeletal reorganization and subsequent engulfment of the apoptotic cell corpse. Has a role in the association of ppk-3 and rab-7 with the phagosomal surface which is necessary for the incorporation of lysosomes to phagosomes during phagosome maturation. Activates the expression of unfolded protein response genes, which are involved in the immune response to live bacteria (By similarity). (1134 aa)
CBG16073Protein CBG16073. (502 aa)
CBG16381Protein CBG16381. (516 aa)
twf-2Protein CBG16364. (376 aa)
CBG16347Protein CBG16347. (191 aa)
cas-1Adenylyl cyclase-associated protein; Belongs to the CAP family. (1230 aa)
fln-2Protein CBR-FLN-2.2. (1279 aa)
Cbr-fln-2.1Protein CBR-FLN-2.1. (1967 aa)
cyk-1Protein CBR-CYK-1. (1477 aa)
viro-2Protein CBG16600. (552 aa)
tnt-3Protein CBR-TNT-3. (1198 aa)
mig-2Protein CBR-MIG-2. (195 aa)
hum-4Protein CBR-HUM-4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2720 aa)
Cbr-exc-9Protein CBR-EXC-9. (178 aa)
dbn-1Protein CBG18266. (672 aa)
CBG18400Protein CBG18400. (196 aa)
CBG17945Protein CBG17945. (486 aa)
arx-6Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (169 aa)
arx-3Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (382 aa)
wve-1Protein CBR-WVE-1. (475 aa)
mrck-1Protein CBR-MRCK-1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1586 aa)
unc-70Spectrin beta chain; Belongs to the spectrin family. (2370 aa)
ttc-17Protein CBG19140. (1287 aa)
hum-2Protein CBR-HUM-2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1781 aa)
gsnl-1Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. (474 aa)
ehbp-1Protein CBR-EHBP-1. (946 aa)
CBG19348Protein CBG19348. (83 aa)
CBG19471Protein CBG19471. (565 aa)
CBG19457Protein CBG19457. (152 aa)
CBG19533Protein CBG19533. (313 aa)
CBG19647Protein CBG19647; Belongs to the cullin family. (528 aa)
zoo-1Protein CBR-ZOO-1. (1208 aa)
hmp-2Protein CBR-HMP-2. (686 aa)
unc-54Protein CBR-UNC-54; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2004 aa)
unc-5Protein CBR-UNC-5. (922 aa)
CBG20121Protein CBG20121. (89 aa)
hum-5Protein CBR-HUM-5; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (552 aa)
CBG20238Protein CBG20238. (157 aa)
cpn-4Protein CBR-CPN-4. (140 aa)
CBG20438Protein CBG20438. (110 aa)
vab-19Protein CBR-VAB-19. (1059 aa)
egg-3Protein CBR-EGG-3. (419 aa)
ddl-2Protein CBR-DDL-2. (495 aa)
CBG21023Protein CBG21023. (262 aa)
myo-6Protein CBG21212; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1249 aa)
CBG21188Protein CBG21188. (440 aa)
CBG21334Protein CBG21334. (102 aa)
CBG21573Protein CBG21573. (348 aa)
Cbr-tag-273Protein CBR-TAG-273. (598 aa)
CBG21760Protein CBG21760. (1101 aa)
myo-1Protein CBR-LET-75; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2121 aa)
spe-15Protein CBR-SPE-15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1216 aa)
dyb-1Dystrobrevin. (622 aa)
CBG22322Protein CBG22322. (372 aa)
sorb-1Protein CBR-SORB-1. (1129 aa)
CBG22502Protein CBG22502. (675 aa)
pat-6Protein CBR-PAT-6. (379 aa)
aipl-1Protein CBR-TAG-216. (599 aa)
tth-1Protein CBR-TTH-1. (151 aa)
atn-1Protein CBR-ATN-1. (894 aa)
hmp-1Protein CBR-HMP-1. (917 aa)
act-2Protein CBR-ACT-2. (376 aa)
act-4Protein CBG23090. (376 aa)
inft-2Protein CBR-INFT-2. (1159 aa)
CBG11409Protein CBG11409. (685 aa)
CBG25604Protein CBG25604. (262 aa)
CBG27374Protein CBG27374. (172 aa)
CBG27110Protein CBG27110. (104 aa)
CBG25881Protein CBG25881. (157 aa)
CBG25883Protein CBG25883. (536 aa)
CBG26587Protein CBG26587. (599 aa)
Cbr-fozi-1Protein CBG25476. (73 aa)
CBG25215Protein CBG25215. (112 aa)
CBG26279Protein CBG26279. (303 aa)
CBG27527Protein CBG27527. (428 aa)
CBG26242Protein CBG26242. (46 aa)
CBG14590Protein CBG14590. (434 aa)
CBG16668Protein CBG16668. (2334 aa)
CBG27040Protein CBG27040. (268 aa)
CBG25001Coronin; Belongs to the WD repeat coronin family. (168 aa)
unc-53Protein CBR-UNC-53, isoform a. (1778 aa)
CBG29119Protein CBG29119. (274 aa)
myo-3Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. (1969 aa)
lev-11Tropomyosin; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin (By similarity). (256 aa)
ced-4Cell death protein 4; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to induce caspase ced-3 autoproteolytic cleavage and activation. Also forms an holoenzyme with processed ced-3 enhancing ced-3 activity. Component of the egl-1, ced-9, ced-4 and ced- 3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During [...] (569 aa)
unc-98Zinc finger protein unc-98; Probable transcription factor. Required for muscle structure. Its dual subcellular localization suggests that it may function both as a muscle adhesion complex protein and as a transcription factor, or work together with transcription factors, to influence gene expression. Thought to act as a molecular bridge between unc-97 and mhc-a at the M- line of muscles, possibly in a signaling role (By similarity). (308 aa)
arx-2Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (393 aa)
arx-1Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (426 aa)
hum-6Unconventional myosin heavy chain 6; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2099 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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