STRINGSTRING
arx-4 arx-4 fli-1 fli-1 gex-2 gex-2 CBG02114 CBG02114 CBG03256 CBG03256 cap-2 cap-2 unc-94 unc-94 viln-1 viln-1 arx-7 arx-7 pfn-1 pfn-1 cap-1 cap-1 daam-1 daam-1 CBG06442 CBG06442 unc-60 unc-60 CBG06893 CBG06893 pfn-3 pfn-3 CBG10797 CBG10797 tmd-2 tmd-2 unc-73 unc-73 cas-2 cas-2 CBG13014 CBG13014 eps-8 eps-8 spc-1 spc-1 unc-78 unc-78 add-1 add-1 CBG14672 CBG14672 CBG14863 CBG14863 arx-5 arx-5 twf-2 twf-2 dbn-1 dbn-1 arx-6 arx-6 arx-3 arx-3 unc-70 unc-70 gsnl-1 gsnl-1 CBG20438 CBG20438 vab-19 vab-19 add-2 add-2 sma-1 sma-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
arx-4Protein CBR-ARX-4. (539 aa)
fli-1Protein CBR-FLI-1. (1271 aa)
gex-2Protein CBR-GEX-2. (1278 aa)
CBG02114Protein CBG02114. (114 aa)
CBG03256Protein CBG03256. (972 aa)
cap-2F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (271 aa)
unc-94Protein CBR-UNC-94. (406 aa)
viln-1Protein CBG03958. (901 aa)
arx-7Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (152 aa)
pfn-1Profilin; Belongs to the profilin family. (132 aa)
cap-1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (282 aa)
daam-1Protein CBR-DAAM-1. (862 aa)
CBG06442Protein CBG06442. (210 aa)
unc-60Protein CBR-UNC-60; Belongs to the actin-binding proteins ADF family. (293 aa)
CBG06893Protein CBG06893. (157 aa)
pfn-3Profilin; Belongs to the profilin family. (114 aa)
CBG10797Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (215 aa)
tmd-2Protein CBR-TMD-2. (641 aa)
unc-73Protein CBR-UNC-73. (1618 aa)
cas-2Adenylyl cyclase-associated protein; Belongs to the CAP family. (468 aa)
CBG13014Protein CBG13014. (318 aa)
eps-8Protein CBR-EPS-8. (918 aa)
spc-1Protein CBR-SPC-1. (2467 aa)
unc-78Protein CBR-UNC-78. (611 aa)
add-1Protein CBR-ADD-1. (804 aa)
CBG14672Profilin; Belongs to the profilin family. (131 aa)
CBG14863Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa)
arx-5Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa)
twf-2Protein CBG16364. (376 aa)
dbn-1Protein CBG18266. (672 aa)
arx-6Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (169 aa)
arx-3Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (382 aa)
unc-70Spectrin beta chain; Belongs to the spectrin family. (2370 aa)
gsnl-1Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. (474 aa)
CBG20438Protein CBG20438. (110 aa)
vab-19Protein CBR-VAB-19. (1059 aa)
add-2Protein CBR-ADD-2. (630 aa)
sma-1Protein CBR-SMA-1. (4156 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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