STRINGSTRING
dcs-1 dcs-1 chn-1 chn-1 CBG12828 CBG12828 daf-16 daf-16 eor-1 eor-1 CBG11134 CBG11134 exos-8 exos-8 CBG11130 CBG11130 CBG11124 CBG11124 atg-2 atg-2 epg-7 epg-7 CBG10273 CBG10273 CBG10274 CBG10274 panl-3 panl-3 mtm-3 mtm-3 cup-5 cup-5 CBG08978 CBG08978 parn-1 parn-1 dcap-1 dcap-1 gsk-3 gsk-3 CBG07264 CBG07264 ccch-1 ccch-1 pqn-39 pqn-39 alg-1 alg-1 rbg-1 rbg-1 nipi-3 nipi-3 laat-1 laat-1 CBG07133 CBG07133 CBG07143 CBG07143 CBG07145 CBG07145 CBG07183 CBG07183 CBG06887 CBG06887 hecd-1 hecd-1 nprl-2 nprl-2 lgg-2 lgg-2 atg-7 atg-7 pha-4 pha-4 CBG05575 CBG05575 exos-7 exos-7 exos-2 exos-2 hlh-30 hlh-30 disl-2 disl-2 ebax-1 ebax-1 epg-8 epg-8 CBG03830 CBG03830 rpb-7 rpb-7 sesn-1 sesn-1 ntl-2 ntl-2 CBG03663 CBG03663 acs-19 acs-19 ser-6 ser-6 ccr-4 ccr-4 pink-1 pink-1 fzy-1 fzy-1 lgg-1 lgg-1 lsm-1 lsm-1 cdc-48.1 cdc-48.1 patr-1 patr-1 CBG03126 CBG03126 exos-3 exos-3 CBG01923 CBG01923 nprl-3 nprl-3 dcap-2 dcap-2 CBG01454 CBG01454 CBG01467 CBG01467 atg-18 atg-18 CBG00902 CBG00902 let-23 let-23 CBG00506 CBG00506 CBG23841 CBG23841 CBG25014 CBG25014 CBG24891 CBG24891 fzr-1 fzr-1 CBG24636 CBG24636 unc-51 unc-51 CBG24565 CBG24565 Cbr-gadr-3 Cbr-gadr-3 CBG22707 CBG22707 CBG22697 CBG22697 CBG22695 CBG22695 CBG22694 CBG22694 CBG22557 CBG22557 CBG22555 CBG22555 CBG22048 CBG22048 CBG21293 CBG21293 CBG21263 CBG21263 nhr-76 nhr-76 CBG21229 CBG21229 CBG21231 CBG21231 mpk-1 mpk-1 CBG20695 CBG20695 ari-1.1 ari-1.1 kin-19 kin-19 ivd-1 ivd-1 ari-2 ari-2 CBG19675 CBG19675 Cbr-tag-153 Cbr-tag-153 mod-1 mod-1 lipl-4 lipl-4 CBG00534 CBG00534 CBG00082 CBG00082 CBG23632 CBG23632 CBG25469 CBG25469 CBG26587 CBG26587 CBG26170 CBG26170 ccf-1 ccf-1 CBG26705 CBG26705 CBG24924 CBG24924 pry-1 pry-1 CBG18766 CBG18766 hsf-1 hsf-1 prde-1 prde-1 CBG18064 CBG18064 pde-12 pde-12 rle-1 rle-1 pdr-1 pdr-1 CBG17760 CBG17760 csr-1 csr-1 CBG16930 CBG16930 CBG16929 CBG16929 CBG16793 CBG16793 exos-9 exos-9 smcr-8 smcr-8 panl-2 panl-2 let-711 let-711 CBG16148 CBG16148 CBG15689 CBG15689 zer-1 zer-1 CBG14615 CBG14615 CBG14564 CBG14564 CBG14552 CBG14552 CBG14550 CBG14550 ufd-2 ufd-2 zyg-11 zyg-11 ntl-3 ntl-3 rsks-1 rsks-1 rpb-4 rpb-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dcs-1Protein CBR-DCS-1. (312 aa)
chn-1Protein CBR-CHN-1. (266 aa)
CBG12828Protein CBG12828. (323 aa)
daf-16Protein CBR-DAF-16. (497 aa)
eor-1Protein CBR-EOR-1. (909 aa)
CBG11134Protein CBG11134. (300 aa)
exos-8Protein CBR-EXOS-8. (361 aa)
CBG11130Protein CBG11130. (295 aa)
CBG11124Protein CBG11124. (812 aa)
atg-2Protein CBR-ATG-2. (2305 aa)
epg-7Protein CBR-ATG-11. (1313 aa)
CBG10273Protein CBG10273. (443 aa)
CBG10274Protein CBG10274. (86 aa)
panl-3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (642 aa)
mtm-3Protein CBR-MTM-3. (1008 aa)
cup-5Protein CBR-CUP-5. (650 aa)
CBG08978RBR-type E3 ubiquitin transferase. (498 aa)
parn-1Protein CBG08556. (556 aa)
dcap-1Protein CBR-DCAP-1. (340 aa)
gsk-3Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting [...] (359 aa)
CBG07264Protein CBG07264. (300 aa)
ccch-1Protein CBG23235. (417 aa)
pqn-39Protein CBR-PQN-39. (758 aa)
alg-1Protein CBR-ALG-1; Belongs to the argonaute family. (1037 aa)
rbg-1Protein CBR-RBG-1. (922 aa)
nipi-3Protein CBR-NIPI-3. (650 aa)
laat-1Protein CBG07028. (310 aa)
CBG07133RBR-type E3 ubiquitin transferase. (403 aa)
CBG07143RBR-type E3 ubiquitin transferase. (557 aa)
CBG07145RBR-type E3 ubiquitin transferase. (474 aa)
CBG07183Protein CBG07183. (780 aa)
CBG06887Protein CBG06887. (480 aa)
hecd-1Protein CBR-HECD-1. (2727 aa)
nprl-2Protein CBG05911. (756 aa)
lgg-2Protein lgg. (130 aa)
atg-7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. (671 aa)
pha-4Protein CBR-PHA-4. (477 aa)
CBG05575Protein CBG05575. (166 aa)
exos-7Protein CBR-EXOS-7. (307 aa)
exos-2Protein CBR-EXOS-2. (305 aa)
hlh-30Protein CBR-HLH-30. (392 aa)
disl-2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. (841 aa)
ebax-1Protein CBR-PQN-55. (1703 aa)
epg-8Protein CBR-EPG-8. (431 aa)
CBG03830Protein CBG03830. (415 aa)
rpb-7Protein CBR-RPB-7. (174 aa)
sesn-1Protein CBG03915. (557 aa)
ntl-2Protein CBR-NTL-2. (491 aa)
CBG03663Protein CBG03663. (723 aa)
acs-19Acetyl-coenzyme A synthetase. (680 aa)
ser-6Protein CBG03354; Belongs to the G-protein coupled receptor 1 family. (400 aa)
ccr-4Protein CBR-CCR-4. (781 aa)
pink-1Protein CBR-PINK-1. (1237 aa)
fzy-1Protein CBR-FZY-1. (521 aa)
lgg-1Protein lgg. (123 aa)
lsm-1U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (125 aa)
cdc-48.1Protein CBG03070; Belongs to the AAA ATPase family. (865 aa)
patr-1Protein PAT1 homolog 1; RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery (By similarity); Belongs to the PAT1 family. (864 aa)
CBG03126Protein CBG03126. (72 aa)
exos-3Protein CBR-EXOS-3. (226 aa)
CBG01923Protein CBG01923. (2041 aa)
nprl-3Protein CBG01588. (490 aa)
dcap-2Protein CBR-DCAP-2. (762 aa)
CBG01454Protein CBG01454. (636 aa)
CBG01467Protein CBG01467. (383 aa)
atg-18Protein CBR-ATG-18. (406 aa)
CBG00902Protein CBG00902. (599 aa)
let-23Receptor protein-tyrosine kinase. (1379 aa)
CBG00506Protein CBG00506. (343 aa)
CBG23841Protein CBG23841. (717 aa)
CBG25014Protein CBG25014. (183 aa)
CBG24891Protein CBG24891. (259 aa)
fzr-1Protein CBR-FZR-1. (708 aa)
CBG24636Protein CBG24636. (770 aa)
unc-51Protein CBR-UNC-51. (875 aa)
CBG24565Protein CBG24565. (1157 aa)
Cbr-gadr-3Protein CBR-GADR-3. (662 aa)
CBG22707RBR-type E3 ubiquitin transferase. (877 aa)
CBG22697Protein CBG22697. (601 aa)
CBG22695Protein CBG22695. (712 aa)
CBG22694Protein CBG22694. (552 aa)
CBG22557Protein CBG22557. (679 aa)
CBG22555Protein CBG22555. (630 aa)
CBG22048Protein CBG22048. (406 aa)
CBG21293Protein CBG21293. (221 aa)
CBG21263RBR-type E3 ubiquitin transferase. (541 aa)
nhr-76Protein CBR-NHR-76. (248 aa)
CBG21229Protein CBG21229. (1384 aa)
CBG21231Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (461 aa)
mpk-1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
CBG20695Protein CBG20695. (93 aa)
ari-1.1RBR-type E3 ubiquitin transferase. (494 aa)
kin-19Protein CBR-KIN-19; Belongs to the protein kinase superfamily. (342 aa)
ivd-1Protein CBR-IVD-1. (417 aa)
ari-2RBR-type E3 ubiquitin transferase. (415 aa)
CBG19675RBR-type E3 ubiquitin transferase. (460 aa)
Cbr-tag-153Protein CBR-TAG-153. (760 aa)
mod-1Protein CBR-MOD-1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (490 aa)
lipl-4Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (423 aa)
CBG00534Protein CBG00534. (504 aa)
CBG00082Protein CBG00082. (740 aa)
CBG23632Protein CBG23632. (169 aa)
CBG25469Protein CBG25469. (244 aa)
CBG26587Protein CBG26587. (599 aa)
CBG26170Protein CBG26170. (87 aa)
ccf-1Protein CBG13315. (315 aa)
CBG26705Protein CBG26705. (108 aa)
CBG24924Protein CBG24924. (389 aa)
pry-1Axin-like protein pry-1; Works in parallel with axl-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Inhibits Wnt signaling, which affects tissue specific expression of Hox genes, egl- 5, lin-39 and mab-5. This in turn affects QR (postembryonic neuroblast) cell migration, vulval cell fate specification, and the development of sensory structures by the seam cell lineage. Has a role in alae V cell patterning, ray formation in the male tail and axon guidance. Does not affect B cell polarity (By similarity). (625 aa)
CBG18766Protein CBG18766. (102 aa)
hsf-1Protein CBR-HSF-1. (504 aa)
prde-1Protein CBG18603. (553 aa)
CBG18064Protein CBG18064. (987 aa)
pde-12Protein CBG18301. (651 aa)
rle-1Protein CBR-RLE-1. (1001 aa)
pdr-1E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (385 aa)
CBG17760RBR-type E3 ubiquitin transferase. (441 aa)
csr-1Protein CBR-CSR-1. (1003 aa)
CBG16930Protein CBG16930. (204 aa)
CBG16929Protein CBG16929. (126 aa)
CBG16793Protein CBG16793. (773 aa)
exos-9Protein CBR-EXOS-9. (434 aa)
smcr-8Protein CBG16529. (511 aa)
panl-2Protein CBG16490. (1149 aa)
let-711Protein CBR-LET-711. (2627 aa)
CBG16148Protein CBG16148. (505 aa)
CBG15689Protein CBG15689. (192 aa)
zer-1Protein CBR-ZER-1. (909 aa)
CBG14615Protein CBG14615. (689 aa)
CBG14564Protein CBG14564; Belongs to the protein kinase superfamily. (342 aa)
CBG14552Protein CBG14552. (102 aa)
CBG14550Protein CBG14550. (534 aa)
ufd-2Protein CBR-UFD-2. (1035 aa)
zyg-11Protein CBR-ZYG-11. (807 aa)
ntl-3Protein CBR-NTL-3. (727 aa)
rsks-1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (540 aa)
rpb-4Protein CBR-RPB-4. (144 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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