(22 nodes) Endosome transport via multivesicular body sorting pathway network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CBG00308	Protein CBG00308. (620 aa)
	vps-60	Protein CBG01476. (217 aa)
	CBG03253	Protein CBG03253. (425 aa)
	CBG02590	Protein CBG02590. (132 aa)
	CBG02567	Protein CBG02567. (233 aa)
	vps-24	Protein CBG02295. (201 aa)
	did-2	Protein CBG03984. (205 aa)
	CBG03988	Protein CBG03988. (157 aa)
	stam-1	Protein CBR-STAM-1. (471 aa)
	vps-32.1	Protein CBR-VPS-32.1. (222 aa)
	ego-2	Protein CBR-EGO-2. (1434 aa)
	vps-20	Protein CBR-VPS-20. (205 aa)
	vps-2	Protein CBR-VPS-2. (239 aa)
	ubxn-6	Protein CBR-UBXN-6. (585 aa)
	vps-25	Protein CBR-VPS-25. (179 aa)
	CBG15030	Protein CBG15030. (289 aa)
	mvb-12	Protein CBR-MVB-12. (281 aa)
	vps-22	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (269 aa)
	vps-28	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. (209 aa)
	sand-1	Protein CBR-SAND-1. (460 aa)
	CBG20395	Protein CBG20395. (195 aa)
	vps-36	Protein CBR-VPS-36. (383 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG02567	CBG03253	A8WU12	A8WSG3	Protein CBG02567.	Protein CBG03253.	0.983
CBG02567	CBG15030	A8WU12	A8XL87	Protein CBG02567.	Protein CBG15030.	0.836
CBG02567	CBG20395	A8WU12	A8XXP2	Protein CBG02567.	Protein CBG20395.	0.897
CBG02567	did-2	A8WU12	A8WVX0	Protein CBG02567.	Protein CBG03984.	0.963
CBG02567	ego-2	A8WU12	A8WXE7	Protein CBG02567.	Protein CBR-EGO-2.	0.773
CBG02567	mvb-12	A8WU12	A8XRI4	Protein CBG02567.	Protein CBR-MVB-12.	0.818
CBG02567	stam-1	A8WU12	A8WW10	Protein CBG02567.	Protein CBR-STAM-1.	0.693
CBG02567	vps-2	A8WU12	A8X558	Protein CBG02567.	Protein CBR-VPS-2.	0.982
CBG02567	vps-20	A8WU12	A8WZ63	Protein CBG02567.	Protein CBR-VPS-20.	0.982
CBG02567	vps-22	A8WU12	A8XS54	Protein CBG02567.	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.938
CBG02567	vps-24	A8WU12	A8WUN5	Protein CBG02567.	Protein CBG02295.	0.985
CBG02567	vps-25	A8WU12	A8XIA2	Protein CBG02567.	Protein CBR-VPS-25.	0.930
CBG02567	vps-28	A8WU12	A8XWB7	Protein CBG02567.	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process.	0.884
CBG02567	vps-32.1	A8WU12	A8WX86	Protein CBG02567.	Protein CBR-VPS-32.1.	0.918
CBG02567	vps-36	A8WU12	A8Y4S8	Protein CBG02567.	Protein CBR-VPS-36.	0.930
CBG02567	vps-60	A8WU12	A8WQL4	Protein CBG02567.	Protein CBG01476.	0.951
CBG02590	CBG03988	A8WTZ1	A8WVX5	Protein CBG02590.	Protein CBG03988.	0.973
CBG03253	CBG02567	A8WSG3	A8WU12	Protein CBG03253.	Protein CBG02567.	0.983
CBG03253	CBG15030	A8WSG3	A8XL87	Protein CBG03253.	Protein CBG15030.	0.922
CBG03253	CBG20395	A8WSG3	A8XXP2	Protein CBG03253.	Protein CBG20395.	0.871