(39 nodes) Genitalia morphogenesis network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cdk-2	Protein CBR-CDK-2; Belongs to the protein kinase superfamily. (340 aa)
	CBG00043	Protein CBG00043. (163 aa)
	ptr-20	Protein CBR-PTR-20. (894 aa)
	ptr-18	Protein CBR-PTR-18. (905 aa)
	lin-29	Protein CBR-LIN-29. (591 aa)
	smg-5	Protein CBR-SMG-5. (551 aa)
	vab-3	Protein CBR-VAB-3. (290 aa)
	CBG04481	Protein CBG04481. (254 aa)
	unc-112	Protein CBR-UNC-112. (720 aa)
	sma-2	Dwarfin sma. (399 aa)
	smg-2	Protein CBR-SMG-2. (1051 aa)
	grd-9	Protein CBR-GRD-9. (512 aa)
	pdi-3	Protein disulfide-isomerase. (488 aa)
	lfe-2	Kinase; Belongs to the inositol phosphokinase (IPK) family. (393 aa)
	CBG10795	Protein CBG10795. (126 aa)
	ptr-2	Protein CBR-PTR-2. (948 aa)
	rab-8	Protein CBR-RAB-8. (211 aa)
	smp-2	Protein CBR-SMP-2; Belongs to the semaphorin family. (689 aa)
	unc-73	Protein CBR-UNC-73. (1618 aa)
	sin-3	Protein CBR-SIN-3. (1544 aa)
	wrt-1	Protein CBR-WRT-1. (490 aa)
	Cbr-kel-10	Protein CBR-KEL-10. (524 aa)
	plx-1	Protein CBR-PLX-1. (1959 aa)
	ipp-5	Protein CBR-IPP-5. (408 aa)
	ptr-4	Protein CBR-PTR-4. (989 aa)
	cogc-1	Protein CBR-COGC-1. (522 aa)
	smg-6	Protein CBR-SMG-6. (773 aa)
	Cbr-pat-4	Protein CBR-PAT-4. (278 aa)
	sma-3	Dwarfin sma. (365 aa)
	ptr-1	Protein CBR-PTR-1. (951 aa)
	grd-6	Protein CBR-GRD-6. (640 aa)
	ptr-23	Protein CBR-PTR-23. (982 aa)
	smp-1	Protein CBR-SMP-1; Belongs to the semaphorin family. (714 aa)
	grd-8	Protein CBR-GRD-8. (381 aa)
	CBG25217	Protein CBG25217. (292 aa)
	itr-1	Protein CBR-ITR-1, isoform a. (2921 aa)
	cye-1	G1/S-specific cyclin-E; Essential for the control of the cell cycle at the G1/S (start) transition. In association with cdk-2, regulates proliferation, quiescent state and cell fate during the development of several cell lineages. In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase. During the development of the vulva, controls the onset of vulval cell terminal differentiation by controlling the duration of G1 phase. During hypoderm development at early larval stages, controls syncytial fate of [...] (518 aa)
	mab-21	Protein male abnormal 21; Acts in a cell autonomous fashion to specify the properties of the sensory ray and non-autonomously in the choice of hypodermal versus neuroblast cell fate. (364 aa)
	mab-5	Protein CBR-MAB-5. (202 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG00043	vab-3	A8WM72	A8WXS6	Protein CBG00043.	Protein CBR-VAB-3.	0.416
CBG04481	sma-2	A8WXS7	A8X3D3	Protein CBG04481.	Dwarfin sma.	0.488
CBG04481	sma-3	A8WXS7	A8XPG1	Protein CBG04481.	Dwarfin sma.	0.520
CBG04481	vab-3	A8WXS7	A8WXS6	Protein CBG04481.	Protein CBR-VAB-3.	0.427
CBG10795	ipp-5	A8XBT6	A8XKR4	Protein CBG10795.	Protein CBR-IPP-5.	0.734
CBG10795	itr-1	A8XBT6	H8WGV2	Protein CBG10795.	Protein CBR-ITR-1, isoform a.	0.658
CBG25217	cogc-1	B6IJH5	A8XL52	Protein CBG25217.	Protein CBR-COGC-1.	0.550
Cbr-pat-4	unc-112	A8XMT5	A8WXX4	Protein CBR-PAT-4.	Protein CBR-UNC-112.	0.998
cdk-2	cye-1	A8XL31	Q8MUK3	Protein CBR-CDK-2; Belongs to the protein kinase superfamily.	G1/S-specific cyclin-E; Essential for the control of the cell cycle at the G1/S (start) transition. In association with cdk-2, regulates proliferation, quiescent state and cell fate during the development of several cell lineages. In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase. During the development of the vulva, controls the onset of vulval cell terminal differentiation by controlling the duration of G1 phase. During hypoderm development at early larval stages, controls syncytial fate of [...]	0.996
cogc-1	CBG25217	A8XL52	B6IJH5	Protein CBR-COGC-1.	Protein CBG25217.	0.550
cye-1	cdk-2	Q8MUK3	A8XL31	G1/S-specific cyclin-E; Essential for the control of the cell cycle at the G1/S (start) transition. In association with cdk-2, regulates proliferation, quiescent state and cell fate during the development of several cell lineages. In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase. During the development of the vulva, controls the onset of vulval cell terminal differentiation by controlling the duration of G1 phase. During hypoderm development at early larval stages, controls syncytial fate of [...]	Protein CBR-CDK-2; Belongs to the protein kinase superfamily.	0.996
grd-9	wrt-1	A8X9F3	A8XGU2	Protein CBR-GRD-9.	Protein CBR-WRT-1.	0.667
ipp-5	CBG10795	A8XKR4	A8XBT6	Protein CBR-IPP-5.	Protein CBG10795.	0.734
ipp-5	itr-1	A8XKR4	H8WGV2	Protein CBR-IPP-5.	Protein CBR-ITR-1, isoform a.	0.741
ipp-5	lfe-2	A8XKR4	A8XBT5	Protein CBR-IPP-5.	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.972
itr-1	CBG10795	H8WGV2	A8XBT6	Protein CBR-ITR-1, isoform a.	Protein CBG10795.	0.658
itr-1	ipp-5	H8WGV2	A8XKR4	Protein CBR-ITR-1, isoform a.	Protein CBR-IPP-5.	0.741
itr-1	lfe-2	H8WGV2	A8XBT5	Protein CBR-ITR-1, isoform a.	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.658
lfe-2	ipp-5	A8XBT5	A8XKR4	Kinase; Belongs to the inositol phosphokinase (IPK) family.	Protein CBR-IPP-5.	0.972
lfe-2	itr-1	A8XBT5	H8WGV2	Kinase; Belongs to the inositol phosphokinase (IPK) family.	Protein CBR-ITR-1, isoform a.	0.658