(48 nodes) Positive regulation of multicellular organism growth network (Caenorhabditis briggsae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dpy-11	Protein CBR-DPY-11. (246 aa)
	hse-5	Protein CBR-HSE-5. (618 aa)
	sma-9	Protein CBR-SMA-9. (2493 aa)
	hst-2	Protein CBR-HST-2. (368 aa)
	adt-2	Protein CBR-ADT-2. (1065 aa)
	sma-3	Dwarfin sma. (365 aa)
	sma-5	Protein CBR-SMA-5; Belongs to the protein kinase superfamily. (491 aa)
	daf-2	Protein CBR-DAF-2. (1840 aa)
	dss-1	Probable 26S proteasome complex subunit dss-1; Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. Has an essential role in oogenesis and larval growth. Required for intestinal function and default lifespan (By similarity). (76 aa)
	dpy-1	Protein CBR-DPY-1. (1470 aa)
	unc-40	Protein CBR-UNC-40. (1407 aa)
	hst-6	Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (379 aa)
	spc-1	Protein CBR-SPC-1. (2467 aa)
	cnnm-3	Protein CBG14121. (417 aa)
	che-2	Protein CBR-CHE-2. (761 aa)
	dpy-18	Protein CBR-DPY-18. (1008 aa)
	gld-3	Protein CBR-GLD-3. (956 aa)
	swsn-1	Protein CBR-SWSN-1. (799 aa)
	lrp-1	Protein CBR-LRP-1. (4829 aa)
	unc-104	Protein CBR-UNC-104; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1699 aa)
	unc-10	Protein CBR-UNC-10. (1636 aa)
	unc-44.1	Protein CBG09456. (1857 aa)
	unc-44.2	Protein CBG09473. (5237 aa)
	daf-4	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (742 aa)
	sma-4	Dwarfin sma. (603 aa)
	nol-2	Protein CBR-NOL-1; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (678 aa)
	sma-2	Dwarfin sma. (399 aa)
	pde-2	Phosphodiesterase. (959 aa)
	nac-2	Protein CBR-NAC-2. (566 aa)
	let-653	Protein CBR-LET-653. (736 aa)
	pept-1	Protein CBR-PEPT-1. (838 aa)
	lin-35	Protein CBR-LIN-35. (956 aa)
	sam-4	Protein CBG02460. (245 aa)
	phb-2	Prohibitin. (294 aa)
	sma-6	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (629 aa)
	raga-1	Protein CBR-RAGA-1. (312 aa)
	kin-29	Serine/threonine-protein kinase kin-29; Regulates chemoreceptor expression by phosphorylating the hda-4 class II histone deacetylase (HDAC) and inhibiting the gene repression functions of hda-4 and the mef-2 transcription factor, enabling the correct sensing and transduction of food signals. Role in determining body size, the dauer decision and serotonin-mediated egg laying. May modulate the Sma/Mab pathway and regulates development in the later larval stages (By similarity). (813 aa)
	tsp-21	Tetraspanin. (298 aa)
	unc-26	Protein CBR-UNC-26. (1123 aa)
	cnnm-1	Protein CBG00360. (801 aa)
	umps-1	Protein CBR-UMPS-1. (498 aa)
	dbl-1	Protein CBR-DBL-1. (373 aa)
	phb-1	Prohibitin. (275 aa)
	drag-1	Protein CBR-DRAG-1. (414 aa)
	sma-10	Protein CBG22529. (879 aa)
	sma-1	Protein CBR-SMA-1. (4156 aa)
	CBG25156	Protein CBG25156. (183 aa)
	unc-53	Protein CBR-UNC-53, isoform a. (1778 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
adt-2	dbl-1	A8XPQ5	A8XUK2	Protein CBR-ADT-2.	Protein CBR-DBL-1.	0.632
adt-2	sma-10	A8XPQ5	A8Y2H5	Protein CBR-ADT-2.	Protein CBG22529.	0.541
adt-2	sma-9	A8XPQ5	A8XRB2	Protein CBR-ADT-2.	Protein CBR-SMA-9.	0.640
che-2	lin-35	A8XIE0	A8WW47	Protein CBR-CHE-2.	Protein CBR-LIN-35.	0.448
che-2	unc-10	A8XIE0	A8XC13	Protein CBR-CHE-2.	Protein CBR-UNC-10.	0.595
daf-2	daf-4	A8XMN1	A8X847	Protein CBR-DAF-2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.709
daf-2	dbl-1	A8XMN1	A8XUK2	Protein CBR-DAF-2.	Protein CBR-DBL-1.	0.786
daf-2	pept-1	A8XMN1	A8WZ37	Protein CBR-DAF-2.	Protein CBR-PEPT-1.	0.642
daf-4	daf-2	A8X847	A8XMN1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Protein CBR-DAF-2.	0.709
daf-4	dbl-1	A8X847	A8XUK2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Protein CBR-DBL-1.	0.998
daf-4	drag-1	A8X847	A8Y1N0	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Protein CBR-DRAG-1.	0.433
daf-4	kin-29	A8X847	A8WRV1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Serine/threonine-protein kinase kin-29; Regulates chemoreceptor expression by phosphorylating the hda-4 class II histone deacetylase (HDAC) and inhibiting the gene repression functions of hda-4 and the mef-2 transcription factor, enabling the correct sensing and transduction of food signals. Role in determining body size, the dauer decision and serotonin-mediated egg laying. May modulate the Sma/Mab pathway and regulates development in the later larval stages (By similarity).	0.650
daf-4	sma-10	A8X847	A8Y2H5	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Protein CBG22529.	0.917
daf-4	sma-2	A8X847	A8X3D3	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Dwarfin sma.	0.636
daf-4	sma-3	A8X847	A8XPG1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Dwarfin sma.	0.636
daf-4	sma-4	A8X847	A8X7T9	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Dwarfin sma.	0.735
daf-4	sma-6	A8X847	A8WTW1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.989
daf-4	sma-9	A8X847	A8XRB2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Protein CBR-SMA-9.	0.829
dbl-1	adt-2	A8XUK2	A8XPQ5	Protein CBR-DBL-1.	Protein CBR-ADT-2.	0.632
dbl-1	daf-2	A8XUK2	A8XMN1	Protein CBR-DBL-1.	Protein CBR-DAF-2.	0.786