STRINGSTRING
vps-34 vps-34 ttr-52 ttr-52 nex-1 nex-1 rab-7 rab-7 CBG20134 CBG20134 sand-1 sand-1 bec-1 bec-1 CBG19476 CBG19476 lst-4 lst-4 nex-3 nex-3 mig-2 mig-2 ced-1 ced-1 ced-10 ced-10 ced-2 ced-2 vps-18 vps-18 ced-12 ced-12 unc-73 unc-73 unc-108 unc-108 ccz-1 ccz-1 ced-7 ced-7 crn-2 crn-2 crp-1 crp-1 ced-6 ced-6 ced-5 ced-5 gsk-3 gsk-3 CBG07900 CBG07900 dyn-1 dyn-1 rab-14 rab-14 mom-5 mom-5 snx-1 snx-1 crn-3 crn-3 CBG01467 CBG01467 atg-18 atg-18 cmd-1 cmd-1 CBG24636 CBG24636 unc-51 unc-51 nex-2 nex-2 piki-1 piki-1 snx-6 snx-6 CBG25881 CBG25881 CBG26259 CBG26259 CBG26388 CBG26388 ced-8 ced-8 cpl-1 cpl-1 klf-1 klf-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
vps-34Phosphatidylinositol 3-kinase catalytic subunit type 3. (895 aa)
ttr-52Protein CBR-TTR-52. (136 aa)
nex-1Annexin. (322 aa)
rab-7Protein CBR-RAB-7. (209 aa)
CBG20134Protein CBG20134; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (824 aa)
sand-1Protein CBR-SAND-1. (460 aa)
bec-1Protein CBR-BEC-1. (375 aa)
CBG19476Protein CBG19476. (106 aa)
lst-4Sorting nexin; Belongs to the sorting nexin family. (595 aa)
nex-3Annexin. (317 aa)
mig-2Protein CBR-MIG-2. (195 aa)
ced-1Cell death abnormality protein 1; Involved in programmed cell death/apoptosis. Acts by recruiting ced-6 to phagosomes which enables actin-dependent cytoskeletal reorganization and subsequent engulfment of the apoptotic cell corpse. Has a role in the association of ppk-3 and rab-7 with the phagosomal surface which is necessary for the incorporation of lysosomes to phagosomes during phagosome maturation. Activates the expression of unfolded protein response genes, which are involved in the immune response to live bacteria (By similarity). (1134 aa)
ced-10Protein CBG15031. (191 aa)
ced-2Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Also has a role in the migration of the 2 gonadal distal tip cells (DTCs) (By similarity). Belongs to the CRK family. (277 aa)
vps-18Protein CBG13485. (940 aa)
ced-12Cell death abnormality protein 12; Involved in apoptosis and necrosis. Required for the cell corpse engulfment process. Has roles in the formation of actin halos and distal tip cell migration. Plays no role in amphid axon outgrowth (By similarity). (740 aa)
unc-73Protein CBR-UNC-73. (1618 aa)
unc-108Protein CBR-UNC-108. (214 aa)
ccz-1Protein CBR-CCZ-1. (530 aa)
ced-7Protein CBR-CED-7. (1784 aa)
crn-2Protein CBR-CRN-2. (300 aa)
crp-1Protein CBR-CRP-1. (187 aa)
ced-6Protein CBR-CED-6. (490 aa)
ced-5Protein CBR-CED-5; Belongs to the DOCK family. (1820 aa)
gsk-3Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting [...] (359 aa)
CBG07900Protein CBG07900. (409 aa)
dyn-1Protein CBR-DYN-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1440 aa)
rab-14Protein CBR-RAB-14. (210 aa)
mom-5Protein CBR-MOM-5; Belongs to the G-protein coupled receptor Fz/Smo family. (570 aa)
snx-1Protein CBR-SNX-1. (472 aa)
crn-3Protein CBR-CRN-3. (868 aa)
CBG01467Protein CBG01467. (383 aa)
atg-18Protein CBR-ATG-18. (406 aa)
cmd-1Protein CBR-CMD-1; Belongs to the calmodulin family. (149 aa)
CBG24636Protein CBG24636. (770 aa)
unc-51Protein CBR-UNC-51. (875 aa)
nex-2Annexin. (499 aa)
piki-1Protein CBR-PIKI-1; Belongs to the PI3/PI4-kinase family. (1680 aa)
snx-6Protein CBR-SNX-6. (838 aa)
CBG25881Protein CBG25881. (157 aa)
CBG26259Protein CBG26259. (132 aa)
CBG26388Protein CBG26388. (223 aa)
ced-8Cell death abnormality protein 8; Acts downstream of ced-9 and caspase ced-3 to promote phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Regulates apoptosis kinetics during embryonic development. Not required for engulfment of germ cell corpses. (460 aa)
cpl-1Protein CBR-CPL-1; Belongs to the peptidase C1 family. (336 aa)
klf-1Protein CBR-KLF-1. (558 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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