(13 nodes) Regulation of MAP kinase activity network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	oma-2	Protein CBR-OMA-2. (379 aa)
	fem-3	Sex-determination protein fem-3; Required for male development. In XO (male) animals, fem-3 directs male differentiation in all tissues. In XX (hermaphrodite animals), it specifies the first 80 or so germ cells to be sperm. Negatively regulates male development when bound to tra-2. (409 aa)
	CBG03052	Protein CBG03052. (74 aa)
	gck-1	Protein CBR-GCK-1. (898 aa)
	CBG20695	Protein CBG20695. (93 aa)
	kin-18	Protein CBR-KIN-18. (743 aa)
	paqr-3	Protein CBR-PAQR-3. (326 aa)
	ccm-3	Protein CBG03050. (215 aa)
	nekl-4	Protein CBR-NEKL-4. (1572 aa)
	lip-1	Protein CBR-LIP-1. (376 aa)
	nipi-3	Protein CBR-NIPI-3. (650 aa)
	CBG15664	Protein CBG15664; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (200 aa)
	cav-1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (239 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG03052	ccm-3	A8WSW7	A8WSW9	Protein CBG03052.	Protein CBG03050.	0.540
CBG03052	gck-1	A8WSW7	A8XUW9	Protein CBG03052.	Protein CBR-GCK-1.	0.914
CBG15664	paqr-3	A8XMH6	A8Y086	Protein CBG15664; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein CBR-PAQR-3.	0.583
ccm-3	CBG03052	A8WSW9	A8WSW7	Protein CBG03050.	Protein CBG03052.	0.540
ccm-3	gck-1	A8WSW9	A8XUW9	Protein CBG03050.	Protein CBR-GCK-1.	0.914
gck-1	CBG03052	A8XUW9	A8WSW7	Protein CBR-GCK-1.	Protein CBG03052.	0.914
gck-1	ccm-3	A8XUW9	A8WSW9	Protein CBR-GCK-1.	Protein CBG03050.	0.914
gck-1	kin-18	A8XUW9	A8XZG6	Protein CBR-GCK-1.	Protein CBR-KIN-18.	0.410
kin-18	gck-1	A8XZG6	A8XUW9	Protein CBR-KIN-18.	Protein CBR-GCK-1.	0.410
paqr-3	CBG15664	A8Y086	A8XMH6	Protein CBR-PAQR-3.	Protein CBG15664; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.583