(50 nodes) Regulation of MAPK cascade network (Caenorhabditis briggsae)

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second shell of interactors

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Known Interactions

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Predicted Interactions

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Your Input:
	fem-3	Sex-determination protein fem-3; Required for male development. In XO (male) animals, fem-3 directs male differentiation in all tissues. In XX (hermaphrodite animals), it specifies the first 80 or so germ cells to be sperm. Negatively regulates male development when bound to tra-2. (409 aa)
	trf-2	Protein CBG23748. (294 aa)
	CBG01796	Protein CBG01796. (564 aa)
	CBG01733	Protein CBG01733. (299 aa)
	CBG01732	Protein CBG01732. (549 aa)
	tpa-1	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (705 aa)
	svh-1	Protein CBR-TRY-2; Belongs to the peptidase S1 family. (921 aa)
	ndk-1	Nucleoside diphosphate kinase. (153 aa)
	CBG03052	Protein CBG03052. (74 aa)
	ccm-3	Protein CBG03050. (215 aa)
	CBG02812	Protein CBG02812. (389 aa)
	CBG02810	Protein CBG02810. (320 aa)
	Cbr-max-2	Protein CBR-MAX-2; Belongs to the protein kinase superfamily. (422 aa)
	max-2	Protein CBG02801. (317 aa)
	vhp-1	Protein CBR-VHP-1. (672 aa)
	stam-1	Protein CBR-STAM-1. (471 aa)
	riok-1	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (515 aa)
	nekl-4	Protein CBR-NEKL-4. (1572 aa)
	CBG06087	Protein CBG06087. (233 aa)
	lip-1	Protein CBR-LIP-1. (376 aa)
	rog-1	Protein CBR-ROG-1. (661 aa)
	jip-1	Protein CBR-JIP-1. (385 aa)
	CBG07104	Protein CBG07104. (529 aa)
	flr-4	Protein CBR-FLR-4. (580 aa)
	tap-1	Protein CBR-TAP-1. (389 aa)
	CBG08107	Protein CBG08107. (328 aa)
	ppm-1.a	Protein CBR-PPM-1. (468 aa)
	unc-16	Protein CBR-UNC-16. (1158 aa)
	hen-1	Protein CBR-HEN-1. (118 aa)
	CBG10838	Protein CBG10838. (249 aa)
	svh-2	Protein CBG10839; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1120 aa)
	lin-44	Abnormal cell lineage protein 44; Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Affects male tail development, vulval precursor cell specification and egg laying. Involved in morphogenesis by influencing polarity of asymmetric cell divisions of the B, U, and F cells in the male, and the T cell in males and hermaphrodites. Controls spindle orientation in B-gamma cell division during male copulatory spicule development. Involved in specification of the P7.p lineage during vulval development. Has a role in providing polarity and default lin-17 [...] (341 aa)
	CBG12570	Protein CBG12570. (1945 aa)
	puf-8	Protein CBR-PUF-8. (535 aa)
	cst-1	Serine/threonine-protein kinase cst-1 18kDa subunit; Serine/threonine-protein kinase which extends lifespan and delays tissue aging, probably by activating daf-16. (494 aa)
	pak-1	Non-specific serine/threonine protein kinase. (626 aa)
	cav-1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (239 aa)
	daf-2	Protein CBR-DAF-2. (1840 aa)
	sem-5	Protein CBR-SEM-5. (229 aa)
	pde-6	Phosphodiesterase. (705 aa)
	gck-1	Protein CBR-GCK-1. (898 aa)
	kin-18	Protein CBR-KIN-18. (743 aa)
	trf-1	Protein CBR-TRF-1. (439 aa)
	praf-3	PRA1 family protein. (189 aa)
	paqr-3	Protein CBR-PAQR-3. (326 aa)
	oma-2	Protein CBR-OMA-2. (379 aa)
	gap-3	Protein CBG22075. (960 aa)
	CBG23363	Protein CBG23363. (206 aa)
	pak-2	Non-specific serine/threonine protein kinase. (515 aa)
	mig-15	Protein CBR-MIG-15, isoform a. (1070 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG01732	CBG23363	A8WQZ4	A8Y437	Protein CBG01732.	Protein CBG23363.	0.599
CBG01732	sem-5	A8WQZ4	A8XPY6	Protein CBG01732.	Protein CBR-SEM-5.	0.599
CBG01732	stam-1	A8WQZ4	A8WW10	Protein CBG01732.	Protein CBR-STAM-1.	0.439
CBG01733	CBG23363	A8WQZ3	A8Y437	Protein CBG01733.	Protein CBG23363.	0.599
CBG01733	sem-5	A8WQZ3	A8XPY6	Protein CBG01733.	Protein CBR-SEM-5.	0.599
CBG01733	stam-1	A8WQZ3	A8WW10	Protein CBG01733.	Protein CBR-STAM-1.	0.439
CBG03052	ccm-3	A8WSW7	A8WSW9	Protein CBG03052.	Protein CBG03050.	0.540
CBG03052	gck-1	A8WSW7	A8XUW9	Protein CBG03052.	Protein CBR-GCK-1.	0.914
CBG06087	ndk-1	A8X0X8	A8WS68	Protein CBG06087.	Nucleoside diphosphate kinase.	0.552
CBG07104	unc-16	A8X3P3	A8XA98	Protein CBG07104.	Protein CBR-UNC-16.	0.750
CBG23363	CBG01732	A8Y437	A8WQZ4	Protein CBG23363.	Protein CBG01732.	0.599
CBG23363	CBG01733	A8Y437	A8WQZ3	Protein CBG23363.	Protein CBG01733.	0.599
CBG23363	Cbr-max-2	A8Y437	A8WTH2	Protein CBG23363.	Protein CBR-MAX-2; Belongs to the protein kinase superfamily.	0.452
CBG23363	daf-2	A8Y437	A8XMN1	Protein CBG23363.	Protein CBR-DAF-2.	0.958
CBG23363	lip-1	A8Y437	A8X1U3	Protein CBG23363.	Protein CBR-LIP-1.	0.533
CBG23363	max-2	A8Y437	A8WTH3	Protein CBG23363.	Protein CBG02801.	0.452
CBG23363	pak-1	A8Y437	A8XKR6	Protein CBG23363.	Non-specific serine/threonine protein kinase.	0.452
CBG23363	pak-2	A8Y437	A8Y4R7	Protein CBG23363.	Non-specific serine/threonine protein kinase.	0.445
CBG23363	rog-1	A8Y437	A8X3J3	Protein CBG23363.	Protein CBR-ROG-1.	0.827
CBG23363	sem-5	A8Y437	A8XPY6	Protein CBG23363.	Protein CBR-SEM-5.	0.901