(35 nodes) Dicarboxylic acid metabolic process network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	alh-6	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (563 aa)
	CBG09091	Protein CBG09091. (348 aa)
	mdh-1	Malate dehydrogenase. (336 aa)
	haly-1	Histidine ammonia-lyase; Belongs to the PAL/histidase family. (747 aa)
	CBG09080	Protein CBG09080. (387 aa)
	CBG09051	Protein CBG09051. (139 aa)
	fum-1	Protein CBR-FUM-1. (491 aa)
	CBG11570	Protein CBG11570. (324 aa)
	men-1	Malic enzyme. (620 aa)
	CBG25625	Protein CBG25625. (220 aa)
	pqn-53	Protein CBR-PQN-53. (348 aa)
	kmo-1	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (461 aa)
	mel-32	Serine hydroxymethyltransferase; Interconversion of serine and glycine. (511 aa)
	prdh-1	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (608 aa)
	CBG17472	Protein CBG17472. (445 aa)
	CBG13687	Protein CBG13687. (670 aa)
	flu-2	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (483 aa)
	mdh-2	Malate dehydrogenase. (341 aa)
	CBG15343	Protein CBG15343. (298 aa)
	got-1.2	Aspartate aminotransferase. (408 aa)
	Cbr-got-1.3	Protein CBR-GOT-1.3. (397 aa)
	CBG01975	Protein CBG01975. (2174 aa)
	glna-3	Protein CBR-GLNA-3. (600 aa)
	gdh-1	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (536 aa)
	got-2.2	Aspartate aminotransferase. (414 aa)
	ddo-2	D-aspartate oxidase 2; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate. Highest catalytic efficiency for D-Glu followed by D-Asp and NMDA. May play a role in the egg-laying events and early development of the worm, in addition to quality control of the germ cells. Belongs to the DAMOX/DASOX family. (331 aa)
	glna-1	Protein CBR-GLNA-1. (825 aa)
	hphd-1	Hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG. Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. (465 aa)
	alh-3	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)
	CBG06696	Protein CBG06696. (137 aa)
	dhfr-1	Protein CBG12356; Belongs to the dihydrofolate reductase family. (189 aa)
	haao-1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (281 aa)
	oatr-1	Protein CBG09115; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (422 aa)
	glna-2	Protein CBR-GLNA-2. (662 aa)
	got-2.1	Aspartate aminotransferase. (419 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG01975	Cbr-got-1.3	A8WRQ4	A8XNT7	Protein CBG01975.	Protein CBR-GOT-1.3.	0.462
CBG01975	alh-6	A8WRQ4	A8X3N9	Protein CBG01975.	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.921
CBG01975	fum-1	A8WRQ4	A8X890	Protein CBG01975.	Protein CBR-FUM-1.	0.428
CBG01975	gdh-1	A8WRQ4	A8X0P1	Protein CBG01975.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.999
CBG01975	glna-1	A8WRQ4	A8WX31	Protein CBG01975.	Protein CBR-GLNA-1.	0.981
CBG01975	glna-2	A8WRQ4	A8XHY8	Protein CBG01975.	Protein CBR-GLNA-2.	0.981
CBG01975	glna-3	A8WRQ4	A8WJ54	Protein CBG01975.	Protein CBR-GLNA-3.	0.981
CBG01975	got-1.2	A8WRQ4	A8XNT6	Protein CBG01975.	Aspartate aminotransferase.	0.462
CBG01975	got-2.1	A8WRQ4	A8Y1V2	Protein CBG01975.	Aspartate aminotransferase.	0.471
CBG01975	got-2.2	A8WRQ4	A8WYZ3	Protein CBG01975.	Aspartate aminotransferase.	0.471
CBG01975	mdh-1	A8WRQ4	A8XUF7	Protein CBG01975.	Malate dehydrogenase.	0.834
CBG01975	mdh-2	A8WRQ4	A8XLN4	Protein CBG01975.	Malate dehydrogenase.	0.834
CBG01975	mel-32	A8WRQ4	Q60V73	Protein CBG01975.	Serine hydroxymethyltransferase; Interconversion of serine and glycine.	0.420
CBG01975	men-1	A8WRQ4	B6ILL0	Protein CBG01975.	Malic enzyme.	0.587
CBG01975	oatr-1	A8WRQ4	E3CU08	Protein CBG01975.	Protein CBG09115; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.626
CBG09051	CBG25625	A8X7X4	B6IFB0	Protein CBG09051.	Protein CBG25625.	0.420
CBG09051	Cbr-got-1.3	A8X7X4	A8XNT7	Protein CBG09051.	Protein CBR-GOT-1.3.	0.701
CBG09051	fum-1	A8X7X4	A8X890	Protein CBG09051.	Protein CBR-FUM-1.	0.784
CBG09051	got-1.2	A8X7X4	A8XNT6	Protein CBG09051.	Aspartate aminotransferase.	0.701
CBG09051	got-2.1	A8X7X4	A8Y1V2	Protein CBG09051.	Aspartate aminotransferase.	0.749