STRINGSTRING
mys-1 mys-1 Cbr-tbx-11 Cbr-tbx-11 CBG24079 CBG24079 CBG24197 CBG24197 CBG24198 CBG24198 mab-9.2 mab-9.2 CBG24389 CBG24389 tbx-9 tbx-9 tbx-8 tbx-8 gld-1 gld-1 sea-1.1 sea-1.1 mig-5 mig-5 mop-25.2 mop-25.2 unc-4 unc-4 let-23 let-23 ref-1 ref-1 pax-3 pax-3 tbx-35 tbx-35 pig-1 pig-1 blmp-1 blmp-1 dep-1 dep-1 ect-2 ect-2 lin-29 lin-29 egl-44 egl-44 vrk-1 vrk-1 hlh-14 hlh-14 dsh-2 dsh-2 nsy-1 nsy-1 lin-22 lin-22 eel-1 eel-1 cwn-2 cwn-2 bed-3 bed-3 egl-20 egl-20 pat-3 pat-3 CBG03606 CBG03606 CBG03609 CBG03609 tir-1 tir-1 CBG03616 CBG03616 CBG04001 CBG04001 lim-7 lim-7 lin-17 lin-17 pop-1 pop-1 rba-1 rba-1 cfi-1 cfi-1 sys-1 sys-1 mom-5 mom-5 ztf-11 ztf-11 CBG04336 CBG04336 CBG04337 CBG04337 CBG04338 CBG04338 tbx-11 tbx-11 vab-3 vab-3 CBG04481 CBG04481 mex-3 mex-3 CBG05212 CBG05212 lag-1 lag-1 CBG05575 CBG05575 pha-4 pha-4 dmd-3 dmd-3 let-60 let-60 lip-1 lip-1 rga-4 rga-4 ceh-34 ceh-34 glp-1 glp-1 lin-12.2 lin-12.2 CBG06829 CBG06829 pat-2 pat-2 lin-12.1 lin-12.1 mab-9.1 mab-9.1 cwn-1 cwn-1 CBG07744 CBG07744 pag-3 pag-3 tap-1 tap-1 elt-3 elt-3 sel-7 sel-7 ztf-6 ztf-6 sel-12 sel-12 pha-2 pha-2 CBG08191 CBG08191 apr-1 apr-1 nmy-2 nmy-2 CBG08365 CBG08365 elt-7 elt-7 tbx-7 tbx-7 CBG09017 CBG09017 CBG09014 CBG09014 wrm-1 wrm-1 CBG08958 CBG08958 mls-1 mls-1 ceh-22 ceh-22 mab-23 mab-23 dsl-7 dsl-7 fos-1 fos-1 fozi-1 fozi-1 CBG10973 CBG10973 CBG10974 CBG10974 bar-1 bar-1 egl-27 egl-27 end-1 end-1 end-3.1 end-3.1 end-3.2 end-3.2 mom-2 mom-2 sea-1.3 sea-1.3 sea-1.2 sea-1.2 sea-1.4 sea-1.4 eor-1 eor-1 pie-1 pie-1 CBG11789 CBG11789 lin-59 lin-59 lin-44 lin-44 lin-11 lin-11 aha-1 aha-1 sup-17 sup-17 sem-2 sem-2 CBG12840 CBG12840 let-381 let-381 sin-3 sin-3 tbx-38 tbx-38 pen-2 pen-2 ham-1 ham-1 egl-18 egl-18 elt-6 elt-6 dsl-3 dsl-3 Cbr-nhr-146 Cbr-nhr-146 CBG13578 CBG13578 CBG13949 CBG13949 lin-32 lin-32 fkh-2 fkh-2 lim-4 lim-4 lin-18 lin-18 CBG14447 CBG14447 ham-2 ham-2 CBG14562 CBG14562 egl-13 egl-13 bet-1 bet-1 CBG15067 CBG15067 tbx-43 tbx-43 let-765 let-765 par-2 par-2 osm-11 osm-11 ceh-37 ceh-37 ceh-36 ceh-36 unc-86 unc-86 ceh-20 ceh-20 sox-2 sox-2 CBG16744 CBG16744 ref-2 ref-2 adm-4 adm-4 hlh-8 hlh-8 CBG17261 CBG17261 elt-2 elt-2 CBG17250 CBG17250 hmg-1.2 hmg-1.2 strd-1 strd-1 cnt-2 cnt-2 atx-2 atx-2 met-2 met-2 eya-1 eya-1 egl-46 egl-46 rtfo-1 rtfo-1 unc-42 unc-42 CBG19636 CBG19636 CBG20004 CBG20004 dsl-1 dsl-1 elt-1 elt-1 CBG20121 CBG20121 cam-1 cam-1 sptf-3 sptf-3 mig-14 mig-14 CBG20849 CBG20849 mex-1 mex-1 tbx-37 tbx-37 tbx-2 tbx-2 aph-2 aph-2 CBG21760 CBG21760 lag-2 lag-2 ast-1 ast-1 hlh-2 hlh-2 lin-41 lin-41 drag-1 drag-1 tln-1 tln-1 CBG22257 CBG22257 src-1 src-1 ksr-1 ksr-1 sor-3 sor-3 ceh-16 ceh-16 rnp-1 rnp-1 aph-1 aph-1 CBG26666 CBG26666 CBG25918 CBG25918 Cbr-fozi-1 Cbr-fozi-1 CBG27628 CBG27628 CBG27978 CBG27978 CBG26414 CBG26414 CBG26283 CBG26283 CBG25184 CBG25184 CBG23879 CBG23879 pes-1 pes-1 pos-1 pos-1 pos-1a pos-1a lin-28 lin-28 lin-53 lin-53 fog-1 fog-1 fog-3 fog-3 lin-25 lin-25 mab-21 mab-21
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
mys-1Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (473 aa)
Cbr-tbx-11Protein CBR-TBX-11. (350 aa)
CBG24079Protein CBG24079. (90 aa)
CBG24197Protein CBG24197. (188 aa)
CBG24198Protein CBG24198. (188 aa)
mab-9.2Protein CBR-MAB-9.2. (342 aa)
CBG24389Protein CBG24389. (114 aa)
tbx-9Protein CBR-TBX-9. (317 aa)
tbx-8Protein CBR-TBX-8. (308 aa)
gld-1Protein CBR-GLD-1. (467 aa)
sea-1.1Protein CBG00340. (614 aa)
mig-5Protein CBR-MIG-5. (657 aa)
mop-25.2Protein CBR-MOP-25.2. (338 aa)
unc-4Protein CBR-UNC-4. (251 aa)
let-23Receptor protein-tyrosine kinase. (1379 aa)
ref-1Protein CBR-REF-1. (375 aa)
pax-3Protein CBR-PAX-3. (335 aa)
tbx-35Protein CBR-TBX-35. (298 aa)
pig-1Non-specific serine/threonine protein kinase. (704 aa)
blmp-1Protein CBR-BLMP-1. (799 aa)
dep-1Protein CBR-DEP-1. (1385 aa)
ect-2Protein CBR-ECT-2. (958 aa)
lin-29Protein CBR-LIN-29. (591 aa)
egl-44Protein CBR-EGL-44. (472 aa)
vrk-1Serine/threonine-protein kinase VRK1; Serine/threonine kinase that phosphorylates baf-1, thus regulating the association of baf-1 with chromatin and nuclear membrane proteins during nuclear envelope formation. May act through the egl-17 signaling pathway. Essential in hermaphrodites for formation of the vulva, uterus, and uterine seam cells and for development and maintenance of the somatic gonad and thus the germ line. Acts to prevent cep-1 from triggering an inappropriate cell cycle arrest, thereby promoting germ cell proliferation. Regulates anchor cell polarity and the timing of an [...] (559 aa)
hlh-14Protein CBR-HLH-14. (150 aa)
dsh-2Protein CBR-DSH-2. (784 aa)
nsy-1Protein CBR-NSY-1. (1577 aa)
lin-22Protein CBR-LIN-22. (164 aa)
eel-1Protein CBR-EEL-1. (4188 aa)
cwn-2Protein CBR-CWN-2. (360 aa)
bed-3Protein CBR-BED-3. (598 aa)
egl-20Protein CBR-EGL-20. (398 aa)
pat-3Integrin beta; Belongs to the integrin beta chain family. (818 aa)
CBG03606Protein CBG03606. (414 aa)
CBG03609Protein CBG03609. (174 aa)
tir-1Protein CBR-TIR-1. (585 aa)
CBG03616Protein CBG03616. (379 aa)
CBG04001Protein CBG04001. (213 aa)
lim-7Protein CBR-LIM-7. (458 aa)
lin-17Protein CBR-LIN-17; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa)
pop-1Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage- derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. Belongs t [...] (439 aa)
rba-1Protein CBR-RBA-1. (418 aa)
cfi-1Protein CBR-CFI-1. (481 aa)
sys-1Protein CBR-SYS-1. (839 aa)
mom-5Protein CBR-MOM-5; Belongs to the G-protein coupled receptor Fz/Smo family. (570 aa)
ztf-11Protein CBR-EKL-2. (586 aa)
CBG04336Protein CBG04336. (614 aa)
CBG04337Protein CBG04337. (331 aa)
CBG04338Protein CBG04338. (312 aa)
tbx-11Protein CBG04534. (348 aa)
vab-3Protein CBR-VAB-3. (290 aa)
CBG04481Protein CBG04481. (254 aa)
mex-3Protein CBR-MEX-3. (494 aa)
CBG05212Protein CBG05212. (352 aa)
lag-1Protein CBR-LAG-1. (681 aa)
CBG05575Protein CBG05575. (166 aa)
pha-4Protein CBR-PHA-4. (477 aa)
dmd-3Protein CBR-DMD-3. (252 aa)
let-60Protein CBR-LET-60. (184 aa)
lip-1Protein CBR-LIP-1. (376 aa)
rga-4Protein CBR-RGA-4. (1095 aa)
ceh-34Protein CBR-CEH-34. (256 aa)
glp-1Protein CBR-GLP-1. (1326 aa)
lin-12.2Protein CBR-LIN-12. (1392 aa)
CBG06829Protein CBG06829. (987 aa)
pat-2Integrin alpha pat-2; Required for muscle development probably through the regulation of the actin-myosin cytoskeleton. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52. Required for distal tip cell migration and dorsal pathfinding. Required for egg-laying. May play a role in cell motility and cell-cell interactions. (1224 aa)
lin-12.1Protein CBG06951. (1359 aa)
mab-9.1Protein CBR-MAB-9.1. (331 aa)
cwn-1Protein CBR-CWN-1. (372 aa)
CBG07744Protein CBG07744. (308 aa)
pag-3Protein CBR-PAG-3. (387 aa)
tap-1Protein CBR-TAP-1. (389 aa)
elt-3Protein CBR-ELT-3. (304 aa)
sel-7Protein CBR-SEL-7. (317 aa)
ztf-6Protein CBR-ZTF-6. (464 aa)
sel-12Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (450 aa)
pha-2Protein CBR-PHA-2. (211 aa)
CBG08191Protein CBG08191. (321 aa)
apr-1APC-related protein 1; Has a role in endoderm cell specification and pharyngeal development. Required for the migration of epithelial cells, organization of the anterior seam cells and ceh-13 expression during embryo morphogenesis. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation. During larval development, apr-1 is required for expression of lin-39 in P3-8.p. Shown to negatively regulate Wnt signaling in vulval precursor cells. Has a role in cell division by establishing the polarity of the mother cel [...] (1171 aa)
nmy-2Protein CBR-NMY-2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2051 aa)
CBG08365Protein CBG08365. (208 aa)
elt-7Protein CBR-ELT-7. (195 aa)
tbx-7Protein CBR-TBX-7. (289 aa)
CBG09017Protein CBG09017. (394 aa)
CBG09014Protein CBG09014. (305 aa)
wrm-1Armadillo repeat-containing protein wrm-1; Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1- dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome [...] (799 aa)
CBG08958Protein CBG08958. (357 aa)
mls-1Protein CBR-MLS-1. (239 aa)
ceh-22Protein CBR-CEH-22. (356 aa)
mab-23Protein CBR-MAB-23. (227 aa)
dsl-7Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (325 aa)
fos-1Protein CBR-FOS-1. (412 aa)
fozi-1Protein CBR-FOZI-1. (688 aa)
CBG10973Protein CBG10973. (372 aa)
CBG10974Protein CBG10974. (318 aa)
bar-1Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...] (808 aa)
egl-27Protein CBR-EGL-27. (1151 aa)
end-1Protein CBR-END-1. (210 aa)
end-3.1Protein CBR-END-3. (253 aa)
end-3.2Protein CBG11404. (248 aa)
mom-2Protein CBR-MOM-2. (358 aa)
sea-1.3Protein CBG11640. (526 aa)
sea-1.2Protein CBR-SEA-1. (566 aa)
sea-1.4Protein CBG11646. (438 aa)
eor-1Protein CBR-EOR-1. (909 aa)
pie-1Protein CBR-PIE-1. (368 aa)
CBG11789Protein CBG11789. (244 aa)
lin-59Protein CBR-LIN-59. (1320 aa)
lin-44Abnormal cell lineage protein 44; Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Affects male tail development, vulval precursor cell specification and egg laying. Involved in morphogenesis by influencing polarity of asymmetric cell divisions of the B, U, and F cells in the male, and the T cell in males and hermaphrodites. Controls spindle orientation in B-gamma cell division during male copulatory spicule development. Involved in specification of the P7.p lineage during vulval development. Has a role in providing polarity and default lin-17 [...] (341 aa)
lin-11Protein CBR-LIN-11. (391 aa)
aha-1Protein CBR-AHA-1. (468 aa)
sup-17Protein CBR-SUP-17. (920 aa)
sem-2Protein CBR-SEM-2. (401 aa)
CBG12840Protein CBG12840. (273 aa)
let-381Protein CBR-LET-381. (363 aa)
sin-3Protein CBR-SIN-3. (1544 aa)
tbx-38Protein CBR-TBX-37. (308 aa)
pen-2Protein CBR-PEN-2. (101 aa)
ham-1Protein CBR-HAM-1. (376 aa)
egl-18Protein CBR-EGL-18. (419 aa)
elt-6Protein CBR-ELT-6. (405 aa)
dsl-3Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (259 aa)
Cbr-nhr-146Protein CBG13577. (196 aa)
CBG13578Protein CBG13578. (340 aa)
CBG13949Protein CBG13949. (167 aa)
lin-32Protein CBR-LIN-32. (148 aa)
fkh-2Protein CBR-FKH-2. (279 aa)
lim-4Protein CBR-LIM-4. (346 aa)
lin-18Protein CBR-LIN-18. (599 aa)
CBG14447Protein CBG14447. (359 aa)
ham-2Protein CBR-HAM-2. (394 aa)
CBG14562Protein CBG14562. (205 aa)
egl-13Protein CBR-EGL-13. (482 aa)
bet-1Protein CBR-BET-1. (772 aa)
CBG15067Protein CBG15067. (253 aa)
tbx-43Protein CBR-TBX-43. (301 aa)
let-765Protein CBR-LET-765. (1839 aa)
par-2Protein CBR-PAR-2. (647 aa)
osm-11Protein CBR-OSM-11. (188 aa)
ceh-37Protein CBR-CEH-37. (287 aa)
ceh-36Protein CBR-CEH-36. (341 aa)
unc-86POU domain protein. (346 aa)
ceh-20Protein CBR-CEH-20. (338 aa)
sox-2Protein CBR-SOX-2. (286 aa)
CBG16744Protein CBG16744. (663 aa)
ref-2Protein CBR-REF-2. (304 aa)
adm-4Protein CBR-ADM-4. (701 aa)
hlh-8Protein CBR-HLH-8. (177 aa)
CBG17261Protein CBG17261. (312 aa)
elt-2Protein CBR-ELT-2. (445 aa)
CBG17250Protein CBG17250. (212 aa)
hmg-1.2Protein CBR-HMG-1.2. (238 aa)
strd-1Protein CBR-STRD-1. (385 aa)
cnt-2Protein CBR-CNT-2. (1161 aa)
atx-2Protein CBR-ATX-2. (1051 aa)
met-2Protein CBR-MET-2. (1269 aa)
eya-1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (483 aa)
egl-46Protein CBR-EGL-46. (283 aa)
rtfo-1Protein CBG19313. (601 aa)
unc-42Protein CBR-UNC-42. (269 aa)
CBG19636Protein CBG19636. (554 aa)
CBG20004Protein CBG20004. (217 aa)
dsl-1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (257 aa)
elt-1Protein CBR-ELT-1. (428 aa)
CBG20121Protein CBG20121. (89 aa)
cam-1Protein CBR-CAM-1. (916 aa)
sptf-3Protein CBR-SPTF-3. (374 aa)
mig-14Protein CBR-MIG-14. (548 aa)
CBG20849Protein CBG20849. (92 aa)
mex-1Protein CBR-MEX-1. (425 aa)
tbx-37Protein CBG20877. (294 aa)
tbx-2Protein CBR-TBX-2. (426 aa)
aph-2Protein CBR-APH-2. (721 aa)
CBG21760Protein CBG21760. (1101 aa)
lag-2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (392 aa)
ast-1Protein CBR-AST-1. (322 aa)
hlh-2Protein CBR-HLH-2. (426 aa)
lin-41Protein CBR-LIN-41. (934 aa)
drag-1Protein CBR-DRAG-1. (414 aa)
tln-1Protein CBG22153. (1036 aa)
CBG22257Protein CBG22257. (370 aa)
src-1Tyrosine-protein kinase. (544 aa)
ksr-1Protein CBR-KSR-1. (812 aa)
sor-3Protein CBR-SOR-3. (491 aa)
ceh-16Protein CBR-CEH-16. (176 aa)
rnp-1Protein CBR-RNP-1. (286 aa)
aph-1Protein CBR-APH-1. (330 aa)
CBG26666Protein CBG26666. (212 aa)
CBG25918Protein CBG25918. (247 aa)
Cbr-fozi-1Protein CBG25476. (73 aa)
CBG27628Protein CBG27628. (685 aa)
CBG27978Protein CBG27978. (169 aa)
CBG26414Protein CBG26414. (458 aa)
CBG26283Protein CBG26283. (252 aa)
CBG25184Protein CBG25184. (1573 aa)
CBG23879Protein CBG23879. (272 aa)
pes-1Protein CBR-PES-1. (172 aa)
pos-1Protein CBR-POS-1. (263 aa)
pos-1aProtein CBG23753. (271 aa)
lin-28Protein lin-28; Heterochronic protein which controls the choice of stage specific cell fates. Regulates the timing of the second larval stage events (L2 events) in the hypodermis (By similarity); Belongs to the lin-28 family. (237 aa)
lin-53Probable histone-binding protein lin-53; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation. Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. (416 aa)
fog-1Protein CBR-FOG-1. (647 aa)
fog-3Protein CBR-FOG-3. (261 aa)
lin-25Protein lin-25; Participates in the inductive signaling pathway downstream of let-60 Ras and the RAF/MAP kinase cascade to regulate specification and differentiation of many cell types. Positively regulates the fate of vulval precursor cells. Required for induction of the P12 and excretory duct cell fates. In males, it is also required for proper formation of spicules. Does not function in the signaling pathway that promotes exit from pachytene (By similarity). (1142 aa)
mab-21Protein male abnormal 21; Acts in a cell autonomous fashion to specify the properties of the sensory ray and non-autonomously in the choice of hypodermal versus neuroblast cell fate. (364 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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