STRINGSTRING
grdn-1 grdn-1 swsn-1 swsn-1 gld-3 gld-3 egl-3 egl-3 daf-4 daf-4 sma-4 sma-4 mlk-1 mlk-1 egl-21 egl-21 arr-1 arr-1 nol-2 nol-2 tax-4 tax-4 sma-2 sma-2 pde-2 pde-2 nac-2 nac-2 CBG06449 CBG06449 let-653 let-653 lon-1 lon-1 pept-1 pept-1 unc-44.1 unc-44.1 unc-44.2 unc-44.2 dpy-18 dpy-18 lin-35 lin-35 rbd-1 rbd-1 mca-3 mca-3 sam-4 sam-4 hlh-14 hlh-14 phb-2 phb-2 sma-6 sma-6 raga-1 raga-1 kin-29 kin-29 tsp-21 tsp-21 pmk-3 pmk-3 unc-26 unc-26 CBG00586 CBG00586 dab-1 dab-1 cnnm-1 cnnm-1 umps-1 umps-1 unc-53 unc-53 CBG25156 CBG25156 CBG26587 CBG26587 sma-1 sma-1 sma-10 sma-10 drag-1 drag-1 phb-1 phb-1 daf-15 daf-15 CBG25106 CBG25106 clk-1 clk-1 daf-22 daf-22 Cbr-mcd-1 Cbr-mcd-1 rig-6 rig-6 unc-5 unc-5 aex-5 aex-5 dbl-1 dbl-1 dpy-11 dpy-11 fsn-1 fsn-1 hse-5 hse-5 dbn-1 dbn-1 sma-9 sma-9 hst-2 hst-2 adt-2 adt-2 mek-1 mek-1 sma-3 sma-3 sma-5 sma-5 kpc-1 kpc-1 daf-2 daf-2 dss-1 dss-1 grk-2 grk-2 dpy-1 dpy-1 unc-40 unc-40 hst-6 hst-6 ncr-1 ncr-1 spc-1 spc-1 cnnm-3 cnnm-3 peb-1 peb-1 mak-2 mak-2 che-2 che-2 rad-8 rad-8 sig-7 sig-7 daf-16 daf-16 mel-26 mel-26 unc-73 unc-73 lrp-1 lrp-1 mboa-6 mboa-6 unc-104 unc-104 bli-4 bli-4 dhs-28 dhs-28 unc-10 unc-10 zag-1 zag-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
grdn-1Protein CBG12901. (1474 aa)
swsn-1Protein CBR-SWSN-1. (799 aa)
gld-3Protein CBR-GLD-3. (956 aa)
egl-3Protein CBR-EGL-3; Belongs to the peptidase S8 family. (662 aa)
daf-4Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (742 aa)
sma-4Dwarfin sma. (603 aa)
mlk-1Protein CBR-MLK-1. (1091 aa)
egl-21Protein CBR-EGL-21. (473 aa)
arr-1Protein CBR-ARR-1. (450 aa)
nol-2Protein CBR-NOL-1; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (678 aa)
tax-4Protein CBR-TAX-4. (726 aa)
sma-2Dwarfin sma. (399 aa)
pde-2Phosphodiesterase. (959 aa)
nac-2Protein CBR-NAC-2. (566 aa)
CBG06449Protein CBG06449. (462 aa)
let-653Protein CBR-LET-653. (736 aa)
lon-1Protein CBR-LON-1; Belongs to the CRISP family. (310 aa)
pept-1Protein CBR-PEPT-1. (838 aa)
unc-44.1Protein CBG09456. (1857 aa)
unc-44.2Protein CBG09473. (5237 aa)
dpy-18Protein CBR-DPY-18. (1008 aa)
lin-35Protein CBR-LIN-35. (956 aa)
rbd-1Protein CBR-RBD-1. (877 aa)
mca-3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1159 aa)
sam-4Protein CBG02460. (245 aa)
hlh-14Protein CBR-HLH-14. (150 aa)
phb-2Prohibitin. (294 aa)
sma-6Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (629 aa)
raga-1Protein CBR-RAGA-1. (312 aa)
kin-29Serine/threonine-protein kinase kin-29; Regulates chemoreceptor expression by phosphorylating the hda-4 class II histone deacetylase (HDAC) and inhibiting the gene repression functions of hda-4 and the mef-2 transcription factor, enabling the correct sensing and transduction of food signals. Role in determining body size, the dauer decision and serotonin-mediated egg laying. May modulate the Sma/Mab pathway and regulates development in the later larval stages (By similarity). (813 aa)
tsp-21Tetraspanin. (298 aa)
pmk-3Mitogen-activated protein kinase. (466 aa)
unc-26Protein CBR-UNC-26. (1123 aa)
CBG00586Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (161 aa)
dab-1Protein CBR-DAB-1. (483 aa)
cnnm-1Protein CBG00360. (801 aa)
umps-1Protein CBR-UMPS-1. (498 aa)
unc-53Protein CBR-UNC-53, isoform a. (1778 aa)
CBG25156Protein CBG25156. (183 aa)
CBG26587Protein CBG26587. (599 aa)
sma-1Protein CBR-SMA-1. (4156 aa)
sma-10Protein CBG22529. (879 aa)
drag-1Protein CBR-DRAG-1. (414 aa)
phb-1Prohibitin. (275 aa)
daf-15Protein CBR-DAF-15. (1795 aa)
CBG25106Protein CBG25106. (639 aa)
clk-15-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (217 aa)
daf-22Protein CBG20965; Belongs to the thiolase-like superfamily. Thiolase family. (372 aa)
Cbr-mcd-1Protein CBR-MCD-1. (869 aa)
rig-6Protein CBR-RIG-6. (1297 aa)
unc-5Protein CBR-UNC-5. (922 aa)
aex-5Protein CBR-AEX-5. (541 aa)
dbl-1Protein CBR-DBL-1. (373 aa)
dpy-11Protein CBR-DPY-11. (246 aa)
fsn-1F-box/SPRY domain-containing protein 1; Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf-2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM and [...] (332 aa)
hse-5Protein CBR-HSE-5. (618 aa)
dbn-1Protein CBG18266. (672 aa)
sma-9Protein CBR-SMA-9. (2493 aa)
hst-2Protein CBR-HST-2. (368 aa)
adt-2Protein CBR-ADT-2. (1065 aa)
mek-1Protein CBR-MEK-1. (463 aa)
sma-3Dwarfin sma. (365 aa)
sma-5Protein CBR-SMA-5; Belongs to the protein kinase superfamily. (491 aa)
kpc-1Protein CBR-KPC-1; Belongs to the peptidase S8 family. (686 aa)
daf-2Protein CBR-DAF-2. (1840 aa)
dss-1Probable 26S proteasome complex subunit dss-1; Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. Has an essential role in oogenesis and larval growth. Required for intestinal function and default lifespan (By similarity). (76 aa)
grk-2Protein CBR-GRK-2. (377 aa)
dpy-1Protein CBR-DPY-1. (1470 aa)
unc-40Protein CBR-UNC-40. (1407 aa)
hst-6Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (379 aa)
ncr-1Protein CBR-NCR-1. (1431 aa)
spc-1Protein CBR-SPC-1. (2467 aa)
cnnm-3Protein CBG14121. (417 aa)
peb-1Protein CBR-PEB-1. (432 aa)
mak-2Protein CBR-MAK-2; Belongs to the protein kinase superfamily. (366 aa)
che-2Protein CBR-CHE-2. (761 aa)
rad-8Protein CBR-RAD-8. (366 aa)
sig-7Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (434 aa)
daf-16Protein CBR-DAF-16. (497 aa)
mel-26Protein CBR-MEL-26. (394 aa)
unc-73Protein CBR-UNC-73. (1618 aa)
lrp-1Protein CBR-LRP-1. (4829 aa)
mboa-6Protein CBG11740; Belongs to the membrane-bound acyltransferase family. (475 aa)
unc-104Protein CBR-UNC-104; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1699 aa)
bli-4Protein CBR-BLI-4; Belongs to the peptidase S8 family. (730 aa)
dhs-28Protein CBR-DHS-28; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (448 aa)
unc-10Protein CBR-UNC-10. (1636 aa)
zag-1Protein CBR-ZAG-1. (618 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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