STRINGSTRING
git-1 git-1 CBG04481 CBG04481 vab-3 vab-3 sys-1 sys-1 pop-1 pop-1 cogc-3 cogc-3 riok-1 riok-1 lin-17 lin-17 cpz-1 cpz-1 lin-35 lin-35 smg-5 smg-5 lim-7 lim-7 mcm-4 mcm-4 fkh-6 fkh-6 rbd-1 rbd-1 gon-1 gon-1 gon-4 gon-4 dsh-2 dsh-2 pkc-3 pkc-3 vrk-1 vrk-1 phb-2 phb-2 ani-2 ani-2 pro-2 pro-2 lin-29 lin-29 ptr-18 ptr-18 max-2 max-2 Cbr-max-2 Cbr-max-2 rsp-1 rsp-1 rsp-2 rsp-2 nuo-1 nuo-1 pro-1 pro-1 ptr-20 ptr-20 blmp-1 blmp-1 cogc-8 cogc-8 pax-3 pax-3 let-23 let-23 dpl-1 dpl-1 iff-2 iff-2 CBG00631 CBG00631 cogc-2 cogc-2 nekl-3 nekl-3 CBG00043 CBG00043 cogc-6.2 cogc-6.2 Cbr-hlh-12 Cbr-hlh-12 pak-1 pak-1 ipp-5 ipp-5 CBG14713 CBG14713 lin-18 lin-18 plx-1 plx-1 CBG13640 CBG13640 Cbr-kel-10 Cbr-kel-10 wrt-1 wrt-1 cki-1 cki-1 swsn-1 swsn-1 sin-3 sin-3 gon-2 gon-2 let-526 let-526 ced-12 ced-12 acin-1 acin-1 hop-1 hop-1 unc-73 unc-73 CBG12075 CBG12075 smp-2 smp-2 rab-8 rab-8 ptr-2 ptr-2 pbrm-1 pbrm-1 CBG11789 CBG11789 ani-1 ani-1 Cbr-cogc-6.2 Cbr-cogc-6.2 sqv-7 sqv-7 unc-6 unc-6 CBG10974 CBG10974 CBG10973 CBG10973 CBG10795 CBG10795 lfe-2 lfe-2 pdi-3 pdi-3 CBG10541 CBG10541 fln-1 fln-1 bub-1 bub-1 grd-9 grd-9 ceh-22 ceh-22 par-3 par-3 CBG09063 CBG09063 par-6 par-6 smg-2 smg-2 ptr-4 ptr-4 swsn-4 swsn-4 lim-6 lim-6 gale-1 gale-1 pix-1 pix-1 nol-2 nol-2 cogc-4 cogc-4 sma-2 sma-2 lin-9 lin-9 lin-3 lin-3 CBG06016 CBG06016 nhr-67 nhr-67 hda-1 hda-1 unc-112 unc-112 unc-40 unc-40 cdk-2 cdk-2 cogc-1 cogc-1 elf-1 elf-1 CBG15416 CBG15416 smg-6 smg-6 Cbr-pat-4 Cbr-pat-4 sma-3 sma-3 ten-1 ten-1 CBG16744 CBG16744 sem-5 sem-5 hmg-1.2 hmg-1.2 dgn-1 dgn-1 rsp-6 rsp-6 unc-34 unc-34 atx-2 atx-2 hlh-12.1 hlh-12.1 CBG18500 CBG18500 dre-1 dre-1 gon-14 gon-14 ptr-1 ptr-1 grd-6 grd-6 CBG19371 CBG19371 ptr-23 ptr-23 smp-1 smp-1 csn-5 csn-5 unc-5 unc-5 grd-8 grd-8 cog-1 cog-1 CBG20918 CBG20918 cacn-1 cacn-1 CBG21034 CBG21034 atp-2 atp-2 lag-2 lag-2 hlh-2 hlh-2 CBG21913 CBG21913 spd-1 spd-1 phb-1 phb-1 src-1 src-1 xnp-1 xnp-1 dcr-1 dcr-1 CBG22975 CBG22975 CBG23363 CBG23363 skp-1 skp-1 ndc-80 ndc-80 mig-17 mig-17 CBG25217 CBG25217 cki-2 cki-2 itr-1 itr-1 CBG23879 CBG23879 Cbr-pro-3 Cbr-pro-3 lin-26 lin-26 let-767 let-767 mig-23 mig-23 mep-1 mep-1 pfd-1 pfd-1 drsh-1 drsh-1 lin-53 lin-53 evl-20.1 evl-20.1 cyd-1 cyd-1 cdk-4 cdk-4 cye-1 cye-1 mab-21 mab-21 mab-5 mab-5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
git-1Protein CBR-GIT-1. (659 aa)
CBG04481Protein CBG04481. (254 aa)
vab-3Protein CBR-VAB-3. (290 aa)
sys-1Protein CBR-SYS-1. (839 aa)
pop-1Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage- derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. Belongs t [...] (439 aa)
cogc-3Protein CBR-COGC-3. (796 aa)
riok-1Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (515 aa)
lin-17Protein CBR-LIN-17; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa)
cpz-1Protein CBR-CPZ-1; Belongs to the peptidase C1 family. (306 aa)
lin-35Protein CBR-LIN-35. (956 aa)
smg-5Protein CBR-SMG-5. (551 aa)
lim-7Protein CBR-LIM-7. (458 aa)
mcm-4DNA helicase; Belongs to the MCM family. (830 aa)
fkh-6Protein CBR-FKH-6. (327 aa)
rbd-1Protein CBR-RBD-1. (877 aa)
gon-1Protein CBR-GON-1. (2153 aa)
gon-4Protein CBR-GON-4. (1350 aa)
dsh-2Protein CBR-DSH-2. (784 aa)
pkc-3Protein kinase C-like 3; Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
vrk-1Serine/threonine-protein kinase VRK1; Serine/threonine kinase that phosphorylates baf-1, thus regulating the association of baf-1 with chromatin and nuclear membrane proteins during nuclear envelope formation. May act through the egl-17 signaling pathway. Essential in hermaphrodites for formation of the vulva, uterus, and uterine seam cells and for development and maintenance of the somatic gonad and thus the germ line. Acts to prevent cep-1 from triggering an inappropriate cell cycle arrest, thereby promoting germ cell proliferation. Regulates anchor cell polarity and the timing of an [...] (559 aa)
phb-2Prohibitin. (294 aa)
ani-2Protein CBR-ANI-2. (1038 aa)
pro-2Nucleolar complex protein 2 homolog; Required for normal somatic gonad development and for regulation of germline development and proliferation; Belongs to the NOC2 family. (719 aa)
lin-29Protein CBR-LIN-29. (591 aa)
ptr-18Protein CBR-PTR-18. (905 aa)
max-2Protein CBG02801. (317 aa)
Cbr-max-2Protein CBR-MAX-2; Belongs to the protein kinase superfamily. (422 aa)
rsp-1Protein CBR-RSP-1. (304 aa)
rsp-2Protein CBR-RSP-2. (256 aa)
nuo-1NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (479 aa)
pro-1Pre-rRNA-processing protein pro-1; Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity). Required for processing ITS2 sequences from rRNA intermediates during 26S rRNA maturation (By similarity). Required in the soma to promote normal proliferation and prevent germline tumor formation (By similarity). (532 aa)
ptr-20Protein CBR-PTR-20. (894 aa)
blmp-1Protein CBR-BLMP-1. (799 aa)
cogc-8Protein CBR-COGC-8. (232 aa)
pax-3Protein CBR-PAX-3. (335 aa)
let-23Receptor protein-tyrosine kinase. (1379 aa)
dpl-1Protein CBR-DPL-1. (603 aa)
iff-2Eukaryotic translation initiation factor 5A. (162 aa)
CBG00631Protein CBG00631. (127 aa)
cogc-2Protein CBR-COGC-2. (684 aa)
nekl-3Protein CBR-NEKL-3. (224 aa)
CBG00043Protein CBG00043. (163 aa)
cogc-6.2Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. (638 aa)
Cbr-hlh-12Protein CBR-HLH-12. (193 aa)
pak-1Non-specific serine/threonine protein kinase. (626 aa)
ipp-5Protein CBR-IPP-5. (408 aa)
CBG14713Protein CBG14713. (113 aa)
lin-18Protein CBR-LIN-18. (599 aa)
plx-1Protein CBR-PLX-1. (1959 aa)
CBG13640Protein CBG13640. (1232 aa)
Cbr-kel-10Protein CBR-KEL-10. (524 aa)
wrt-1Protein CBR-WRT-1. (490 aa)
cki-1Protein CBR-CKI-1. (187 aa)
swsn-1Protein CBR-SWSN-1. (799 aa)
sin-3Protein CBR-SIN-3. (1544 aa)
gon-2Protein CBR-GON-2. (2166 aa)
let-526Protein CBR-LET-526. (1905 aa)
ced-12Cell death abnormality protein 12; Involved in apoptosis and necrosis. Required for the cell corpse engulfment process. Has roles in the formation of actin halos and distal tip cell migration. Plays no role in amphid axon outgrowth (By similarity). (740 aa)
acin-1Protein CBR-ACIN-1. (575 aa)
hop-1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (358 aa)
unc-73Protein CBR-UNC-73. (1618 aa)
CBG12075Protein CBG12075. (611 aa)
smp-2Protein CBR-SMP-2; Belongs to the semaphorin family. (689 aa)
rab-8Protein CBR-RAB-8. (211 aa)
ptr-2Protein CBR-PTR-2. (948 aa)
pbrm-1Protein CBR-PBRM-1. (2017 aa)
CBG11789Protein CBG11789. (244 aa)
ani-1Protein CBR-ANI-1. (1199 aa)
Cbr-cogc-6.2Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. (626 aa)
sqv-7Protein CBR-SQV-7. (328 aa)
unc-6Protein CBR-UNC-6. (621 aa)
CBG10974Protein CBG10974. (318 aa)
CBG10973Protein CBG10973. (372 aa)
CBG10795Protein CBG10795. (126 aa)
lfe-2Kinase; Belongs to the inositol phosphokinase (IPK) family. (393 aa)
pdi-3Protein disulfide-isomerase. (488 aa)
CBG10541Protein CBG10541. (1363 aa)
fln-1Protein CBG10542. (1091 aa)
bub-1Protein CBR-BUB-1. (971 aa)
grd-9Protein CBR-GRD-9. (512 aa)
ceh-22Protein CBR-CEH-22. (356 aa)
par-3Protein CBR-PAR-3. (1332 aa)
CBG09063Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (455 aa)
par-6Protein CBR-PAR-6. (305 aa)
smg-2Protein CBR-SMG-2. (1051 aa)
ptr-4Protein CBR-PTR-4. (989 aa)
swsn-4Protein CBG08287. (1512 aa)
lim-6Protein CBR-LIM-6. (257 aa)
gale-1UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (369 aa)
pix-1Protein CBR-PIX-1. (808 aa)
nol-2Protein CBR-NOL-1; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (678 aa)
cogc-4Protein CBR-COGC-4. (823 aa)
sma-2Dwarfin sma. (399 aa)
lin-9Protein CBR-LIN-9. (641 aa)
lin-3Protein CBR-LIN-3. (450 aa)
CBG06016Protein CBG06016. (1380 aa)
nhr-67Protein CBR-NHR-67. (423 aa)
hda-1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (455 aa)
unc-112Protein CBR-UNC-112. (720 aa)
unc-40Protein CBR-UNC-40. (1407 aa)
cdk-2Protein CBR-CDK-2; Belongs to the protein kinase superfamily. (340 aa)
cogc-1Protein CBR-COGC-1. (522 aa)
elf-1Protein CBR-ELF-1. (428 aa)
CBG15416Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (470 aa)
smg-6Protein CBR-SMG-6. (773 aa)
Cbr-pat-4Protein CBR-PAT-4. (278 aa)
sma-3Dwarfin sma. (365 aa)
ten-1Protein CBR-TEN-1. (2909 aa)
CBG16744Protein CBG16744. (663 aa)
sem-5Protein CBR-SEM-5. (229 aa)
hmg-1.2Protein CBR-HMG-1.2. (238 aa)
dgn-1Protein CBR-DGN-1. (594 aa)
rsp-6Protein CBR-RSP-6. (173 aa)
unc-34Protein CBR-UNC-34. (459 aa)
atx-2Protein CBR-ATX-2. (1051 aa)
hlh-12.1Protein CBG18498. (159 aa)
CBG18500Protein CBG18500. (61 aa)
dre-1Protein CBR-DRE-1. (1045 aa)
gon-14Protein CBR-GON-14. (1018 aa)
ptr-1Protein CBR-PTR-1. (951 aa)
grd-6Protein CBR-GRD-6. (640 aa)
CBG19371Protein CBG19371. (462 aa)
ptr-23Protein CBR-PTR-23. (982 aa)
smp-1Protein CBR-SMP-1; Belongs to the semaphorin family. (714 aa)
csn-5Protein CBR-CSN-5. (367 aa)
unc-5Protein CBR-UNC-5. (922 aa)
grd-8Protein CBR-GRD-8. (381 aa)
cog-1Protein CBR-COG-1. (261 aa)
CBG20918Protein CBG20918. (1587 aa)
cacn-1Protein CBR-CACN-1. (690 aa)
CBG21034Protein CBG21034. (854 aa)
atp-2ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (537 aa)
lag-2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (392 aa)
hlh-2Protein CBR-HLH-2. (426 aa)
CBG21913Protein CBG21913. (618 aa)
spd-1Protein CBR-SPD-1. (523 aa)
phb-1Prohibitin. (275 aa)
src-1Tyrosine-protein kinase. (544 aa)
xnp-1Protein CBR-XNP-1. (1333 aa)
dcr-1Protein CBR-DCR-1; Belongs to the helicase family. Dicer subfamily. (2030 aa)
CBG22975Protein CBG22975. (146 aa)
CBG23363Protein CBG23363. (206 aa)
skp-1Protein CBR-SKP-1. (534 aa)
ndc-80Protein CBR-NDC-80. (599 aa)
mig-17Protein CBR-MIG-17. (533 aa)
CBG25217Protein CBG25217. (292 aa)
cki-2Protein CBR-CKI-2.1. (256 aa)
itr-1Protein CBR-ITR-1, isoform a. (2921 aa)
CBG23879Protein CBG23879. (272 aa)
Cbr-pro-3Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (383 aa)
lin-26Protein CBR-LIN-26. (430 aa)
let-767Very-long-chain 3-oxooacyl-coA reductase let-767; Required for branched chain fatty acid synthesis. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. Very long-chain fatty acids (VLCFAs) serve as precursors for ceramide and sphingolipids. May also be required for sterol hormone production (By similarity). (316 aa)
mig-23Nucleoside-diphosphatase mig-23; Seems to be able to hydrolyze ADP, UDP and GDP. Supports mig- 17 glycosylation and surface expression, which is required for proper migration of distal tip cells during gonad morphogenesis (By similarity). (553 aa)
mep-1MOG interacting and ectopic P-granules protein 1; Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR (By similarity). (880 aa)
pfd-1Probable prefoldin subunit 1; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Has a role in gonadogenesis (By similarity). (117 aa)
drsh-1Ribonuclease 3; Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA (By similarity). Belongs to the ribonuclease III family. (1061 aa)
lin-53Probable histone-binding protein lin-53; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation. Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. (416 aa)
evl-20.1ADP-ribosylation factor-like protein 2; GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics; Belongs to the small GTPase superfamily. Arf family. (184 aa)
cyd-1Protein CBR-CYD-1; Belongs to the cyclin family. (427 aa)
cdk-4Cyclin-dependent kinase CDK-4/6; Belongs to the protein kinase superfamily. (345 aa)
cye-1G1/S-specific cyclin-E; Essential for the control of the cell cycle at the G1/S (start) transition. In association with cdk-2, regulates proliferation, quiescent state and cell fate during the development of several cell lineages. In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase. During the development of the vulva, controls the onset of vulval cell terminal differentiation by controlling the duration of G1 phase. During hypoderm development at early larval stages, controls syncytial fate of [...] (518 aa)
mab-21Protein male abnormal 21; Acts in a cell autonomous fashion to specify the properties of the sensory ray and non-autonomously in the choice of hypodermal versus neuroblast cell fate. (364 aa)
mab-5Protein CBR-MAB-5. (202 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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