STRINGSTRING
vhp-1 vhp-1 gcy-12 gcy-12 lon-1 lon-1 lon-8 lon-8 slt-1 slt-1 CBG08191 CBG08191 CBG08400 CBG08400 smp-2 smp-2 daf-16 daf-16 efa-6 efa-6 lon-2 lon-2 unc-40 unc-40 ppm-2 ppm-2 fsn-1 fsn-1 glo-4 glo-4 smp-1 smp-1 rig-6 rig-6 sor-3 sor-3 CBG23464 CBG23464 lon-3 lon-3 CBG13515 CBG13515 mab-20 mab-20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
vhp-1Protein CBR-VHP-1. (672 aa)
gcy-12Guanylate cyclase. (1690 aa)
lon-1Protein CBR-LON-1; Belongs to the CRISP family. (310 aa)
lon-8Protein CBR-LON-8. (159 aa)
slt-1Protein CBR-SLT-1. (1376 aa)
CBG08191Protein CBG08191. (321 aa)
CBG08400Protein CBG08400. (668 aa)
smp-2Protein CBR-SMP-2; Belongs to the semaphorin family. (689 aa)
daf-16Protein CBR-DAF-16. (497 aa)
efa-6Protein CBR-EFA-6. (836 aa)
lon-2Protein CBR-LON-2. (509 aa)
unc-40Protein CBR-UNC-40. (1407 aa)
ppm-2Protein CBG18025. (352 aa)
fsn-1F-box/SPRY domain-containing protein 1; Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf-2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM and [...] (332 aa)
glo-4Protein CBR-GLO-4. (1392 aa)
smp-1Protein CBR-SMP-1; Belongs to the semaphorin family. (714 aa)
rig-6Protein CBR-RIG-6. (1297 aa)
sor-3Protein CBR-SOR-3. (491 aa)
CBG23464Protein CBG23464. (800 aa)
lon-3Protein CBR-LON-3. (324 aa)
CBG13515Protein CBG13515. (589 aa)
mab-20Semaphorin-2A; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting and allows the formation of distinct sensory rays. Seems to control cell-cell contact formation through 2 parallel pathways, one involving efn-4 and one involving plx-2 and unc-129. Involved in axon guidance. Probably by binding receptor plx-2, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus [...] (656 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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