(37 nodes) Positive regulation of synaptic transmission network (Caenorhabditis briggsae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	daf-2	Protein CBR-DAF-2. (1840 aa)
	unc-18	Protein CBR-UNC-18; Belongs to the STXBP/unc-18/SEC1 family. (590 aa)
	slo-2	Protein CBR-SLO-2. (1098 aa)
	nca-2	Protein CBR-NCA-2. (1809 aa)
	fsn-1	F-box/SPRY domain-containing protein 1; Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf-2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM and [...] (332 aa)
	sol-2	Protein CBG19743. (299 aa)
	mec-15	Protein CBG20219. (368 aa)
	egl-30	Protein CBR-EGL-30. (388 aa)
	dyb-1	Dystrobrevin. (622 aa)
	Cbr-aex-1	Protein CBG26592. (97 aa)
	vha-12	Probable V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Required for necrotic cell death and epidermal cell fusion (By similarity). Belongs to the ATPase alpha/beta chains family. (491 aa)
	ric-3	Resistance to inhibitors of cholinesterase protein 3; Required for maturation and cell surface expression of acetylcholine receptors. (385 aa)
	unc-26	Protein CBR-UNC-26. (1123 aa)
	casy-1	Protein CBR-CASY-1. (983 aa)
	gar-3	Protein CBR-GAR-3; Belongs to the G-protein coupled receptor 1 family. (609 aa)
	unc-77	Protein CBR-NCA-1. (1883 aa)
	egl-8	Phosphoinositide phospholipase C. (1528 aa)
	unc-32	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (953 aa)
	aex-3	Protein CBR-AEX-3. (1500 aa)
	egl-21	Protein CBR-EGL-21. (473 aa)
	ida-1	Protein CBR-IDA-1. (722 aa)
	egl-3	Protein CBR-EGL-3; Belongs to the peptidase S8 family. (662 aa)
	unc-10	Protein CBR-UNC-10. (1636 aa)
	sphk-1	Protein CBR-SPHK-1. (423 aa)
	rpy-1	Protein CBR-RPY-1. (613 aa)
	unc-73	Protein CBR-UNC-73. (1618 aa)
	sol-1	Protein CBR-SOL-1. (596 aa)
	sue-1	Protein CBR-SUE-1. (539 aa)
	aex-1	Protein CBR-AEX-1. (1034 aa)
	unc-29	Protein CBR-UNC-29. (491 aa)
	daf-16	Protein CBR-DAF-16. (497 aa)
	rho-1	Protein CBR-RHO-1. (192 aa)
	CBG13699	Protein CBG13699. (277 aa)
	unc-75	Protein CBR-UNC-75. (515 aa)
	dys-1	Protein CBG15371. (1276 aa)
	Cbr-dys-1	Protein CBR-DYS-1. (2353 aa)
	stg-2	Protein CBR-STG-2. (373 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG13699	unc-73	A8XII0	A8XEH9	Protein CBG13699.	Protein CBR-UNC-73.	0.774
Cbr-aex-1	aex-3	B6IIF2	A8X5V3	Protein CBG26592.	Protein CBR-AEX-3.	0.624
Cbr-dys-1	dyb-1	A8XM22	A8Y1Z6	Protein CBR-DYS-1.	Dystrobrevin.	0.707
Cbr-dys-1	dys-1	A8XM22	A8XM20	Protein CBR-DYS-1.	Protein CBG15371.	0.671
aex-1	aex-3	A8XEN6	A8X5V3	Protein CBR-AEX-1.	Protein CBR-AEX-3.	0.624
aex-3	Cbr-aex-1	A8X5V3	B6IIF2	Protein CBR-AEX-3.	Protein CBG26592.	0.624
aex-3	aex-1	A8X5V3	A8XEN6	Protein CBR-AEX-3.	Protein CBR-AEX-1.	0.624
aex-3	gar-3	A8X5V3	A8WXZ5	Protein CBR-AEX-3.	Protein CBR-GAR-3; Belongs to the G-protein coupled receptor 1 family.	0.405
daf-16	daf-2	A8XFP9	A8XMN1	Protein CBR-DAF-16.	Protein CBR-DAF-2.	0.996
daf-2	daf-16	A8XMN1	A8XFP9	Protein CBR-DAF-2.	Protein CBR-DAF-16.	0.996
dyb-1	Cbr-dys-1	A8Y1Z6	A8XM22	Dystrobrevin.	Protein CBR-DYS-1.	0.707
dyb-1	dys-1	A8Y1Z6	A8XM20	Dystrobrevin.	Protein CBG15371.	0.851
dys-1	Cbr-dys-1	A8XM20	A8XM22	Protein CBG15371.	Protein CBR-DYS-1.	0.671
dys-1	dyb-1	A8XM20	A8Y1Z6	Protein CBG15371.	Dystrobrevin.	0.851
egl-21	egl-3	A8X6C1	A8X8V5	Protein CBR-EGL-21.	Protein CBR-EGL-3; Belongs to the peptidase S8 family.	0.918
egl-21	ida-1	A8X6C1	A8X7T6	Protein CBR-EGL-21.	Protein CBR-IDA-1.	0.696
egl-21	unc-10	A8X6C1	A8XC13	Protein CBR-EGL-21.	Protein CBR-UNC-10.	0.470
egl-21	unc-18	A8X6C1	A8XPR8	Protein CBR-EGL-21.	Protein CBR-UNC-18; Belongs to the STXBP/unc-18/SEC1 family.	0.415
egl-3	egl-21	A8X8V5	A8X6C1	Protein CBR-EGL-3; Belongs to the peptidase S8 family.	Protein CBR-EGL-21.	0.918
egl-3	ida-1	A8X8V5	A8X7T6	Protein CBR-EGL-3; Belongs to the peptidase S8 family.	Protein CBR-IDA-1.	0.851