STRINGSTRING
egl-21 egl-21 akt-1 akt-1 egl-3 egl-3 prk-2 prk-2 unc-6 unc-6 unc-104 unc-104 unc-76 unc-76 unc-69 unc-69 CBG00329 CBG00329 rpm-1 rpm-1 CBG01371 CBG01371 ced-3 ced-3 pmk-3 pmk-3 casy-1 casy-1 vps-35 vps-35 daf-16 daf-16 clr-1 clr-1 bli-4 bli-4 mak-2 mak-2 unc-40 unc-40 CBG15618 CBG15618 daf-2 daf-2 kpc-1 kpc-1 dbn-1 dbn-1 ppm-2 ppm-2 cyy-1 cyy-1 fsn-1 fsn-1 gsnl-1 gsnl-1 aex-5 aex-5 CBG19958 CBG19958 cdk-5 cdk-5 CBG11409 CBG11409 ced-4 ced-4 gon-1 gon-1 syd-2 syd-2 egl-1 egl-1 CBG05428 CBG05428 cima-1 cima-1 pdk-1 pdk-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
egl-21Protein CBR-EGL-21. (473 aa)
akt-1Non-specific serine/threonine protein kinase. (605 aa)
egl-3Protein CBR-EGL-3; Belongs to the peptidase S8 family. (662 aa)
prk-2Protein CBR-PRK-2; Belongs to the protein kinase superfamily. (450 aa)
unc-6Protein CBR-UNC-6. (621 aa)
unc-104Protein CBR-UNC-104; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1699 aa)
unc-76Protein CBR-UNC-76. (232 aa)
unc-69Protein CBR-UNC-69. (108 aa)
CBG00329Protein CBG00329. (294 aa)
rpm-1Protein CBR-RPM-1. (3789 aa)
CBG01371Protein CBG01371; Belongs to the protein kinase superfamily. (372 aa)
ced-3Protein CBR-CED-3; Belongs to the peptidase C14A family. (508 aa)
pmk-3Mitogen-activated protein kinase. (466 aa)
casy-1Protein CBR-CASY-1. (983 aa)
vps-35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (858 aa)
daf-16Protein CBR-DAF-16. (497 aa)
clr-1Protein CBR-CLR-1. (1471 aa)
bli-4Protein CBR-BLI-4; Belongs to the peptidase S8 family. (730 aa)
mak-2Protein CBR-MAK-2; Belongs to the protein kinase superfamily. (366 aa)
unc-40Protein CBR-UNC-40. (1407 aa)
CBG15618Protein CBG15618. (460 aa)
daf-2Protein CBR-DAF-2. (1840 aa)
kpc-1Protein CBR-KPC-1; Belongs to the peptidase S8 family. (686 aa)
dbn-1Protein CBG18266. (672 aa)
ppm-2Protein CBG18025. (352 aa)
cyy-1Protein CBR-CYY-1; Belongs to the cyclin family. (357 aa)
fsn-1F-box/SPRY domain-containing protein 1; Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf-2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM and [...] (332 aa)
gsnl-1Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. (474 aa)
aex-5Protein CBR-AEX-5. (541 aa)
CBG19958Protein CBG19958. (572 aa)
cdk-5Protein CBR-CDK-5; Belongs to the protein kinase superfamily. (292 aa)
CBG11409Protein CBG11409. (685 aa)
ced-4Cell death protein 4; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to induce caspase ced-3 autoproteolytic cleavage and activation. Also forms an holoenzyme with processed ced-3 enhancing ced-3 activity. Component of the egl-1, ced-9, ced-4 and ced- 3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During [...] (569 aa)
gon-1Protein CBR-GON-1. (2153 aa)
syd-2Protein CBR-SYD-2. (1152 aa)
egl-1Protein CBR-EGL-1. (110 aa)
CBG05428Protein CBG05428. (819 aa)
cima-1Protein CBG05932. (544 aa)
pdk-1Protein CBR-PDK-1. (644 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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