(48 nodes) Striated muscle cell development network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CBG13699	Protein CBG13699. (277 aa)
	rho-1	Protein CBR-RHO-1. (192 aa)
	slo-1	Protein CBR-SLO-1. (1165 aa)
	chn-1	Protein CBR-CHN-1. (266 aa)
	mel-26	Protein CBR-MEL-26. (394 aa)
	tnt-4	Protein CBR-TNT-4. (308 aa)
	unc-15	Protein CBR-UNC-15. (872 aa)
	unc-89	Protein CBR-UNC-89. (6561 aa)
	tmd-2	Protein CBR-TMD-2. (641 aa)
	myo-5	Protein CBR-MYO-5; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
	unc-52	Protein CBR-UNC-52. (2481 aa)
	pat-10	Protein CBR-PAT-10. (161 aa)
	unc-96	Protein CBR-UNC-96. (404 aa)
	pfn-3	Profilin; Belongs to the profilin family. (114 aa)
	dyc-1	Protein CBR-DYC-1. (985 aa)
	unc-54	Protein CBR-UNC-54; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2004 aa)
	rnf-5	Protein CBR-RNF-5. (241 aa)
	myo-6	Protein CBG21212; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1249 aa)
	myo-1	Protein CBR-LET-75; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2121 aa)
	dyb-1	Dystrobrevin. (622 aa)
	sorb-1	Protein CBR-SORB-1. (1129 aa)
	pat-6	Protein CBR-PAT-6. (379 aa)
	aipl-1	Protein CBR-TAG-216. (599 aa)
	myo-3	Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. (1969 aa)
	unc-98	Zinc finger protein unc-98; Probable transcription factor. Required for muscle structure. Its dual subcellular localization suggests that it may function both as a muscle adhesion complex protein and as a transcription factor, or work together with transcription factors, to influence gene expression. Thought to act as a molecular bridge between unc-97 and mhc-a at the M- line of muscles, possibly in a signaling role (By similarity). (308 aa)
	Cbr-pat-4	Protein CBR-PAT-4. (278 aa)
	tnt-3	Protein CBR-TNT-3. (1198 aa)
	CBG19533	Protein CBG19533. (313 aa)
	CBG19647	Protein CBG19647; Belongs to the cullin family. (528 aa)
	unc-78	Protein CBR-UNC-78. (611 aa)
	CBG14672	Profilin; Belongs to the profilin family. (131 aa)
	nmy-3	Protein CBG15043; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1526 aa)
	unc-45	Protein CBR-UNC-45. (961 aa)
	dys-1	Protein CBG15371. (1276 aa)
	Cbr-dys-1	Protein CBR-DYS-1. (2353 aa)
	unc-27	Protein CBR-UNC-27. (238 aa)
	tnt-2	Protein CBR-TNT-2. (426 aa)
	unc-60	Protein CBR-UNC-60; Belongs to the actin-binding proteins ADF family. (293 aa)
	cul-3	Protein CBR-CUL-3; Belongs to the cullin family. (810 aa)
	CBG05862	Protein CBG05862. (257 aa)
	unc-82	Protein CBR-UNC-82. (1723 aa)
	mup-2	Protein CBR-MUP-2. (421 aa)
	mei-1	Meiotic spindle formation protein mei-1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays. This activity may promote rapid reorganization of cellular microtubule arrays. Required specifically for meiotic spindle formation in the female germline; the presence of this protein is inimical to the formation of mitotic spindles. (484 aa)
	unc-94	Protein CBR-UNC-94. (406 aa)
	pat-3	Integrin beta; Belongs to the integrin beta chain family. (818 aa)
	fli-1	Protein CBR-FLI-1. (1271 aa)
	Cbr-myo-2	Protein CBR-MYO-2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2009 aa)
	stn-1	Protein CBR-STN-1. (422 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG05862	dyc-1	A8X1G7	A8X512	Protein CBG05862.	Protein CBR-DYC-1.	0.404
CBG05862	unc-15	A8X1G7	A8XEM5	Protein CBG05862.	Protein CBR-UNC-15.	0.658
CBG05862	unc-98	A8X1G7	Q612G6	Protein CBG05862.	Zinc finger protein unc-98; Probable transcription factor. Required for muscle structure. Its dual subcellular localization suggests that it may function both as a muscle adhesion complex protein and as a transcription factor, or work together with transcription factors, to influence gene expression. Thought to act as a molecular bridge between unc-97 and mhc-a at the M- line of muscles, possibly in a signaling role (By similarity).	0.557
CBG13699	CBG14672	A8XII0	A8XKF1	Protein CBG13699.	Profilin; Belongs to the profilin family.	0.742
CBG13699	CBG19533	A8XII0	A8XVU3	Protein CBG13699.	Protein CBG19533.	0.491
CBG13699	CBG19647	A8XII0	A8XW36	Protein CBG13699.	Protein CBG19647; Belongs to the cullin family.	0.491
CBG13699	cul-3	A8XII0	A8X279	Protein CBG13699.	Protein CBR-CUL-3; Belongs to the cullin family.	0.491
CBG13699	pat-3	A8XII0	A8WVF5	Protein CBG13699.	Integrin beta; Belongs to the integrin beta chain family.	0.413
CBG13699	pfn-3	A8XII0	A8X5Q1	Protein CBG13699.	Profilin; Belongs to the profilin family.	0.777
CBG13699	sorb-1	A8XII0	A8Y232	Protein CBG13699.	Protein CBR-SORB-1.	0.426
CBG13699	unc-60	A8XII0	A8X2K2	Protein CBG13699.	Protein CBR-UNC-60; Belongs to the actin-binding proteins ADF family.	0.674
CBG13699	unc-89	A8XII0	A8XEH5	Protein CBG13699.	Protein CBR-UNC-89.	0.948
CBG14672	CBG13699	A8XKF1	A8XII0	Profilin; Belongs to the profilin family.	Protein CBG13699.	0.742
CBG14672	aipl-1	A8XKF1	A8Y2N7	Profilin; Belongs to the profilin family.	Protein CBR-TAG-216.	0.410
CBG14672	rho-1	A8XKF1	A8XIF5	Profilin; Belongs to the profilin family.	Protein CBR-RHO-1.	0.820
CBG14672	tmd-2	A8XKF1	A8XDD4	Profilin; Belongs to the profilin family.	Protein CBR-TMD-2.	0.633
CBG14672	unc-60	A8XKF1	A8X2K2	Profilin; Belongs to the profilin family.	Protein CBR-UNC-60; Belongs to the actin-binding proteins ADF family.	0.861
CBG14672	unc-78	A8XKF1	A8XJI3	Profilin; Belongs to the profilin family.	Protein CBR-UNC-78.	0.655
CBG14672	unc-94	A8XKF1	A8WVR8	Profilin; Belongs to the profilin family.	Protein CBR-UNC-94.	0.665
CBG19533	CBG13699	A8XVU3	A8XII0	Protein CBG19533.	Protein CBG13699.	0.491