STRINGSTRING
lon-2 lon-2 npr-1 npr-1 lfi-1 lfi-1 tom-1 tom-1 mff-2 mff-2 cdk-2 cdk-2 lec-6 lec-6 daf-2 daf-2 Cbr-pat-4 Cbr-pat-4 kpc-1 kpc-1 toca-1 toca-1 CBG16414 CBG16414 ain-1 ain-1 aak-2 aak-2 pdf-1 pdf-1 rod-1 rod-1 vps-52 vps-52 ftt-2 ftt-2 CBG17582 CBG17582 CBG17584 CBG17584 plc-1 plc-1 sma-9 sma-9 hcf-1 hcf-1 CBG17621 CBG17621 brc-2 brc-2 toca-2 toca-2 vps-50 vps-50 atx-2 atx-2 cdka-1 cdka-1 fsn-1 fsn-1 tmem-231 tmem-231 wve-1 wve-1 CBG18780 CBG18780 CBG18798 CBG18798 rme-1 rme-1 mrck-1 mrck-1 bbs-8 bbs-8 frpr-18 frpr-18 gck-1 gck-1 spdl-1 spdl-1 eipr-1 eipr-1 hmp-2 hmp-2 uev-1 uev-1 bec-1 bec-1 sand-1 sand-1 CBG19958 CBG19958 snpn-1 snpn-1 egg-3 egg-3 mig-14 mig-14 sam-10 sam-10 rab-7 rab-7 daf-22 daf-22 cnt-1 cnt-1 vha-19 vha-19 CBG21101 CBG21101 cdk-5 cdk-5 Cbr-tag-164 Cbr-tag-164 tbx-2 tbx-2 ulp-1 ulp-1 arl-8 arl-8 CBG21788 CBG21788 unc-14 unc-14 CBG21913 CBG21913 vps-34 vps-34 egl-30 egl-30 CBG22464 CBG22464 aipl-1 aipl-1 nhr-14 nhr-14 txbp-3 txbp-3 che-11 che-11 hmp-1 hmp-1 ndc-80 ndc-80 CBG11409 CBG11409 CBG26439 CBG26439 CBG25550 CBG25550 CBG25637 CBG25637 CBG25886 CBG25886 CBG25853 CBG25853 CBG27852 CBG27852 CBG19771 CBG19771 air-1 air-1 rme-8 rme-8 zwl-1 zwl-1 cye-1 cye-1 cyd-1 cyd-1 gras-1 gras-1 unc-51 unc-51 CBG24636 CBG24636 sorf-2 sorf-2 arf-6 arf-6 rom-4 rom-4 ulp-4 ulp-4 cdc-48.2 cdc-48.2 asna-1 asna-1 madd-2 madd-2 cmd-1 cmd-1 fbxa-137 fbxa-137 ubc-9 ubc-9 CBG01713 CBG01713 sar-1 sar-1 wapl-1 wapl-1 CBG01673 CBG01673 pmk-1 pmk-1 flp-2 flp-2 CBG02083 CBG02083 trpp-12 trpp-12 CBG02130 CBG02130 CBG02137 CBG02137 CBG03290 CBG03290 spv-1 spv-1 szy-20 szy-20 cdc-48.1 cdc-48.1 adbp-1 adbp-1 CBG03052 CBG03052 ccm-3 ccm-3 ect-2 ect-2 CBG02956 CBG02956 rga-1 rga-1 cgt-3 cgt-3 CBG02513 CBG02513 CBG02510 CBG02510 tbc-2 tbc-2 sam-4 sam-4 vhp-1 vhp-1 ufd-1 ufd-1 gex-3 gex-3 rme-6 rme-6 afd-1 afd-1 vps-51 vps-51 CBG04097 CBG04097 nra-2 nra-2 lab-1 lab-1 CBG03842 CBG03842 syd-2 syd-2 gar-3 gar-3 CBG05231 CBG05231 magi-1 magi-1 CBG06449 CBG06449 lin-40 lin-40 ubxn-3 ubxn-3 pqn-85 pqn-85 Cbr-gpn-1 Cbr-gpn-1 pag-3 pag-3 CBG07612 CBG07612 CBG07243 CBG07243 lgl-1 lgl-1 rund-1 rund-1 CBG08491 CBG08491 scc-3 scc-3 par-6 par-6 cyk-3 cyk-3 wrm-1 wrm-1 nrx-1 nrx-1 egl-9 egl-9 cash-1 cash-1 egl-3 egl-3 wdr-20 wdr-20 cni-1 cni-1 aspm-1 aspm-1 zmp-2 zmp-2 bub-1 bub-1 gcc-2 gcc-2 vps-53 vps-53 CBG10002 CBG10002 emb-9 emb-9 unc-104 unc-104 CBG11217 CBG11217 CBG11786 CBG11786 chs-1 chs-1 rab-8 rab-8 mex-5 mex-5 egg-4 egg-4 unc-89 unc-89 CBG12075 CBG12075 unc-73 unc-73 dhc-1 dhc-1 tomm-7 tomm-7 ppk-1 ppk-1 erm-1 erm-1 sec-12 sec-12 frk-1 frk-1 rab-10 rab-10 unc-87 unc-87 grdn-1 grdn-1 prmt-1 prmt-1 farl-11 farl-11 spe-6 spe-6 ipla-1 ipla-1 eak-7 eak-7 ubc-13 ubc-13 jac-1 jac-1 ubxn-2 ubxn-2 sorf-1 sorf-1 aex-4 aex-4 dpy-23 dpy-23 lnp-1 lnp-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lon-2Protein CBR-LON-2. (509 aa)
npr-1Protein CBR-NPR-1; Belongs to the G-protein coupled receptor 1 family. (453 aa)
lfi-1Protein CBR-LFI-1. (2488 aa)
tom-1Protein CBR-TOM-1. (1101 aa)
mff-2Protein CBR-MFF-2. (162 aa)
cdk-2Protein CBR-CDK-2; Belongs to the protein kinase superfamily. (340 aa)
lec-6Galectin. (146 aa)
daf-2Protein CBR-DAF-2. (1840 aa)
Cbr-pat-4Protein CBR-PAT-4. (278 aa)
kpc-1Protein CBR-KPC-1; Belongs to the peptidase S8 family. (686 aa)
toca-1Protein CBR-TOCA-1. (588 aa)
CBG16414Protein CBG16414. (581 aa)
ain-1Protein CBR-AIN-1. (712 aa)
aak-2Non-specific serine/threonine protein kinase. (641 aa)
pdf-1Protein CBG16474. (86 aa)
rod-1Protein CBR-ROD-1. (2213 aa)
vps-52Protein CBR-VPS-52. (702 aa)
ftt-2Protein CBR-FTT-2; Belongs to the 14-3-3 family. (248 aa)
CBG17582Protein CBG17582. (396 aa)
CBG17584Protein CBG17584. (1313 aa)
plc-1Phosphoinositide phospholipase C. (1917 aa)
sma-9Protein CBR-SMA-9. (2493 aa)
hcf-1Protein CBR-HCF-1. (771 aa)
CBG17621Protein CBG17621. (62 aa)
brc-2Protein CBR-BRC-2. (322 aa)
toca-2Protein CBR-TOCA-2. (677 aa)
vps-50Protein CBG18297. (930 aa)
atx-2Protein CBR-ATX-2. (1051 aa)
cdka-1Cyclin-dependent kinase 5 activator. (366 aa)
fsn-1F-box/SPRY domain-containing protein 1; Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf-2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM and [...] (332 aa)
tmem-231Protein CBG18470. (297 aa)
wve-1Protein CBR-WVE-1. (475 aa)
CBG18780Protein CBG18780. (263 aa)
CBG18798Protein CBG18798. (813 aa)
rme-1Protein CBR-RME-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (611 aa)
mrck-1Protein CBR-MRCK-1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1586 aa)
bbs-8Protein CBR-BBS-8. (498 aa)
frpr-18Protein CBR-FRPR-18; Belongs to the G-protein coupled receptor 1 family. (432 aa)
gck-1Protein CBR-GCK-1. (898 aa)
spdl-1Protein CBR-SPDL-1. (501 aa)
eipr-1Protein CBG19781. (353 aa)
hmp-2Protein CBR-HMP-2. (686 aa)
uev-1Protein CBR-UEV-1. (139 aa)
bec-1Protein CBR-BEC-1. (375 aa)
sand-1Protein CBR-SAND-1. (460 aa)
CBG19958Protein CBG19958. (572 aa)
snpn-1Protein CBG19979. (123 aa)
egg-3Protein CBR-EGG-3. (419 aa)
mig-14Protein CBR-MIG-14. (548 aa)
sam-10Protein CBR-SAM-10. (468 aa)
rab-7Protein CBR-RAB-7. (209 aa)
daf-22Protein CBG20965; Belongs to the thiolase-like superfamily. Thiolase family. (372 aa)
cnt-1Protein CBR-CNT-1. (824 aa)
vha-19Protein CBR-VHA-19. (453 aa)
CBG21101Protein CBG21101. (286 aa)
cdk-5Protein CBR-CDK-5; Belongs to the protein kinase superfamily. (292 aa)
Cbr-tag-164Protein CBR-TAG-164. (267 aa)
tbx-2Protein CBR-TBX-2. (426 aa)
ulp-1Protein CBR-ULP-1. (710 aa)
arl-8Protein CBR-ARL-8; Belongs to the small GTPase superfamily. Arf family. (185 aa)
CBG21788Protein CBG21788. (870 aa)
unc-14Protein CBR-UNC-14. (666 aa)
CBG21913Protein CBG21913. (618 aa)
vps-34Phosphatidylinositol 3-kinase catalytic subunit type 3. (895 aa)
egl-30Protein CBR-EGL-30. (388 aa)
CBG22464Protein CBG22464. (603 aa)
aipl-1Protein CBR-TAG-216. (599 aa)
nhr-14Protein CBR-NHR-14. (440 aa)
txbp-3Protein CBG23021. (124 aa)
che-11Protein CBR-CHE-11. (1436 aa)
hmp-1Protein CBR-HMP-1. (917 aa)
ndc-80Protein CBR-NDC-80. (599 aa)
CBG11409Protein CBG11409. (685 aa)
CBG26439Protein CBG26439. (169 aa)
CBG25550Protein CBG25550. (147 aa)
CBG25637Protein CBG25637. (42 aa)
CBG25886Protein CBG25886. (111 aa)
CBG25853Protein CBG25853. (127 aa)
CBG27852Protein CBG27852. (132 aa)
CBG19771Protein CBG19771. (796 aa)
air-1Protein CBR-AIR-1.1; Belongs to the protein kinase superfamily. (327 aa)
rme-8Protein CBR-RME-8, isoform a. (2341 aa)
zwl-1Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores and spindle pole separation. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome segregation, the complex also inhibits the attachment of [...] (639 aa)
cye-1G1/S-specific cyclin-E; Essential for the control of the cell cycle at the G1/S (start) transition. In association with cdk-2, regulates proliferation, quiescent state and cell fate during the development of several cell lineages. In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase. During the development of the vulva, controls the onset of vulval cell terminal differentiation by controlling the duration of G1 phase. During hypoderm development at early larval stages, controls syncytial fate of [...] (518 aa)
cyd-1Protein CBR-CYD-1; Belongs to the cyclin family. (427 aa)
gras-1Protein CBG23728. (245 aa)
unc-51Protein CBR-UNC-51. (875 aa)
CBG24636Protein CBG24636. (770 aa)
sorf-2Protein CBG24676. (1417 aa)
arf-6Protein CBR-ARF-6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
rom-4Protein CBR-ROM-4. (1189 aa)
ulp-4Protein CBR-ULP-4. (385 aa)
cdc-48.2Protein CBG00746; Belongs to the AAA ATPase family. (811 aa)
asna-1ATPase asna-1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] (345 aa)
madd-2Protein CBR-TRIM-9. (768 aa)
cmd-1Protein CBR-CMD-1; Belongs to the calmodulin family. (149 aa)
fbxa-137Protein CBR-FBXA-137. (321 aa)
ubc-9Protein CBR-UBC-9; Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
CBG01713Protein CBG01713. (217 aa)
sar-1Protein CBG01701; Belongs to the small GTPase superfamily. SAR1 family. (193 aa)
wapl-1Protein CBG01692. (742 aa)
CBG01673Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (4379 aa)
pmk-1Mitogen-activated protein kinase. (377 aa)
flp-2Protein CBR-FLP-2. (73 aa)
CBG02083Protein CBG02083. (761 aa)
trpp-12Protein CBG02113. (389 aa)
CBG02130Protein CBG02130. (188 aa)
CBG02137Protein CBG02137. (97 aa)
CBG03290Protein CBG03290. (169 aa)
spv-1Protein CBR-TAG-341. (855 aa)
szy-20Protein CBR-SZY-20. (514 aa)
cdc-48.1Protein CBG03070; Belongs to the AAA ATPase family. (865 aa)
adbp-1Protein CBR-ADBP-1.1. (209 aa)
CBG03052Protein CBG03052. (74 aa)
ccm-3Protein CBG03050. (215 aa)
ect-2Protein CBR-ECT-2. (958 aa)
CBG02956Protein CBG02956. (196 aa)
rga-1Protein CBR-RGA-1. (439 aa)
cgt-3Protein CBR-CGT-3. (467 aa)
CBG02513Protein CBG02513. (322 aa)
CBG02510Protein CBG02510. (343 aa)
tbc-2Protein CBG02508. (944 aa)
sam-4Protein CBG02460. (245 aa)
vhp-1Protein CBR-VHP-1. (672 aa)
ufd-1Protein CBR-UFD-1. (341 aa)
gex-3Protein CBR-GEX-3. (1140 aa)
rme-6Receptor-mediated endocytosis protein 6; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis. Acts by regulating the activation of rab-5 by exchanging bound GDP for free GTP at clathrin coated pits (By similarity). (1104 aa)
afd-1Protein CBR-AFD-1. (1274 aa)
vps-51Protein CBR-VPS-51. (695 aa)
CBG04097Protein CBG04097. (427 aa)
nra-2Nicalin; Belongs to the nicastrin family. (557 aa)
lab-1Protein CBR-LAB-1. (153 aa)
CBG03842Protein CBG03842. (438 aa)
syd-2Protein CBR-SYD-2. (1152 aa)
gar-3Protein CBR-GAR-3; Belongs to the G-protein coupled receptor 1 family. (609 aa)
CBG05231Protein CBG05231; Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
magi-1Protein CBR-MAGI-1. (910 aa)
CBG06449Protein CBG06449. (462 aa)
lin-40Protein CBR-LIN-40. (1002 aa)
ubxn-3Protein CBR-UBXN-3. (592 aa)
pqn-85Nipped-B protein. (2140 aa)
Cbr-gpn-1Protein CBR-GPN-1; Belongs to the glypican family. (1442 aa)
pag-3Protein CBR-PAG-3. (387 aa)
CBG07612Protein CBG07612. (740 aa)
CBG07243Protein CBG07243. (176 aa)
lgl-1Protein CBR-LGL-1. (969 aa)
rund-1Protein CBG08133. (564 aa)
CBG08491Protein CBG08491. (302 aa)
scc-3Protein CBR-SCC-3. (1122 aa)
par-6Protein CBR-PAR-6. (305 aa)
cyk-3Protein CBR-CYK-3. (1190 aa)
wrm-1Armadillo repeat-containing protein wrm-1; Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1- dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome [...] (799 aa)
nrx-1Protein CBR-NRX-1. (1612 aa)
egl-9Protein CBR-EGL-9. (712 aa)
cash-1Protein CBR-CASH-1. (681 aa)
egl-3Protein CBR-EGL-3; Belongs to the peptidase S8 family. (662 aa)
wdr-20Protein CBR-HPO-22. (763 aa)
cni-1Protein CBR-CNIH-2. (145 aa)
aspm-1Protein CBR-ASPM-1. (1275 aa)
zmp-2Protein CBG09830. (489 aa)
bub-1Protein CBR-BUB-1. (971 aa)
gcc-2Protein CBG09976. (674 aa)
vps-53Protein CBG09978. (796 aa)
CBG10002Protein CBG10002. (768 aa)
emb-9Protein CBR-EMB-9. (1759 aa)
unc-104Protein CBR-UNC-104; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1699 aa)
CBG11217Protein CBG11217. (355 aa)
CBG11786Protein CBG11786. (1010 aa)
chs-1Protein CBR-CHS-1. (1319 aa)
rab-8Protein CBR-RAB-8. (211 aa)
mex-5Protein CBR-MEX-5. (474 aa)
egg-4Protein CBR-EGG-4. (752 aa)
unc-89Protein CBR-UNC-89. (6561 aa)
CBG12075Protein CBG12075. (611 aa)
unc-73Protein CBR-UNC-73. (1618 aa)
dhc-1Protein CBR-DHC-1. (4569 aa)
tomm-7Protein CBR-TOMM-7. (58 aa)
ppk-1Protein CBR-PPK-1. (926 aa)
erm-1Protein CBR-ERM-1. (563 aa)
sec-12Protein CBR-SEC-12. (423 aa)
frk-1Tyrosine-protein kinase. (389 aa)
rab-10Protein CBR-RAB-10. (201 aa)
unc-87Protein CBR-UNC-87. (547 aa)
grdn-1Protein CBG12901. (1474 aa)
prmt-1Protein CBR-PRMT-1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (345 aa)
farl-11Protein CBG13065. (976 aa)
spe-6Protein CBR-SPE-6. (796 aa)
ipla-1Protein CBR-IPLA-1. (750 aa)
eak-7Protein CBR-EAK-7. (397 aa)
ubc-13Protein CBR-UBC-13; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
jac-1Protein CBR-JAC-1. (1296 aa)
ubxn-2Protein CBR-UBXN-2. (702 aa)
sorf-1Protein CBG14197. (239 aa)
aex-4Protein CBR-AEX-4. (209 aa)
dpy-23Protein CBR-DPY-23; Belongs to the adaptor complexes medium subunit family. (435 aa)
lnp-1Endoplasmic reticulum junction formation protein lunapark-1; Plays a role in tubular endoplasmic reticulum network formation and maintenance (By similarity). May be involved in central nervous system development. Has a presynaptic role in neurotransmission. Likely to operate in synaptogenesis by regulating vesicular transport or localization. Required for correct localization of rab-3 and snb-1 (By similarity); Belongs to the lunapark family. (344 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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