STRINGSTRING
arf-1.2 arf-1.2 unc-11 unc-11 rab-8 rab-8 sue-1 sue-1 cup-4 cup-4 erm-1 erm-1 CBG12524 CBG12524 sec-12 sec-12 snt-4 snt-4 rab-10 rab-10 nekl-2 nekl-2 cdc-42 cdc-42 farl-11 farl-11 ced-2 ced-2 CBG13654 CBG13654 sorf-1 sorf-1 rab-37 rab-37 tom-1 tom-1 ced-10 ced-10 snt-2 snt-2 lec-6 lec-6 stim-1 stim-1 toca-1 toca-1 rbf-1 rbf-1 CBG16580 CBG16580 sdpn-1 sdpn-1 CBG16900 CBG16900 gcy-9 gcy-9 esyt-2 esyt-2 CBG17467 CBG17467 CBG17621 CBG17621 pdr-1 pdr-1 toca-2 toca-2 cnt-2 cnt-2 gipc-2 gipc-2 sel-5 sel-5 wve-1 wve-1 CBG18798 CBG18798 mrck-1 mrck-1 gras-1 gras-1 snt-6 snt-6 sorf-2 sorf-2 arf-6 arf-6 itsn-1 itsn-1 dab-1 dab-1 sar-1 sar-1 gex-2 gex-2 CBG01565 CBG01565 wsp-1 wsp-1 CBG02083 CBG02083 CBG02097 CBG02097 ndk-1 ndk-1 CBG03272 CBG03272 CBG03052 CBG03052 ccm-3 ccm-3 CBG02956 CBG02956 rga-1 rga-1 CBG02513 CBG02513 CBG02510 CBG02510 tbc-2 tbc-2 rab-3 rab-3 pld-1 pld-1 gex-3 gex-3 mca-3 mca-3 mom-5 mom-5 CBG04368 CBG04368 abl-1 abl-1 unc-112 unc-112 srgp-1 srgp-1 CBG05923 CBG05923 cla-1 cla-1 snt-5 snt-5 snt-3 snt-3 pat-2 pat-2 piki-1 piki-1 snt-7 snt-7 gsk-3 gsk-3 aex-6 aex-6 CBG08107 CBG08107 jph-1 jph-1 ced-5 ced-5 CBG08577 CBG08577 syx-4 syx-4 abi-1 abi-1 ced-6 ced-6 cup-5 cup-5 mtm-3 mtm-3 cash-1 cash-1 uig-1 uig-1 chc-1 chc-1 ced-7 ced-7 mtm-1 mtm-1 sng-1 sng-1 sphk-1 sphk-1 snt-1 snt-1 swan-1 swan-1 gck-1 gck-1 CBG19188 CBG19188 unc-41 unc-41 CBG19476 CBG19476 CBG19737 CBG19737 bec-1 bec-1 sand-1 sand-1 CBG19958 CBG19958 snpn-1 snpn-1 pph-5 pph-5 CBG20803 CBG20803 rab-7 rab-7 cnt-1 cnt-1 CBG21499 CBG21499 rap-1 rap-1 CBG22081 CBG22081 vps-34 vps-34 CBG22220 CBG22220 CBG22536 CBG22536 CBG22703 CBG22703 CBG23228 CBG23228 CBG26388 CBG26388 CBG04367 CBG04367 CBG18752 CBG18752 CBG19771 CBG19771 tat-1 tat-1 rme-8 rme-8 nrf-5 nrf-5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
arf-1.2ADP-ribosylation factor 1-like 2; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Involved in endoplasmic reticulum dynamics during embryogenesis. Also required for adult germline function (By similarity); Belongs to the small GTPase superfamily. Arf family. (181 aa)
unc-11Protein CBR-UNC-11. (710 aa)
rab-8Protein CBR-RAB-8. (211 aa)
sue-1Protein CBR-SUE-1. (539 aa)
cup-4Acetylcholine receptor-like protein cup-4; Thought to regulate endocytosis in coelomocytes through modulation of phospholipase C activity. Possible acetylcholine receptor (By similarity); Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (435 aa)
erm-1Protein CBR-ERM-1. (563 aa)
CBG12524Protein CBG12524. (421 aa)
sec-12Protein CBR-SEC-12. (423 aa)
snt-4Protein CBR-SNT-4. (381 aa)
rab-10Protein CBR-RAB-10. (201 aa)
nekl-2Protein CBR-NEKL-2; Belongs to the protein kinase superfamily. (358 aa)
cdc-42Protein CBR-CDC-42. (191 aa)
farl-11Protein CBG13065. (976 aa)
ced-2Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Also has a role in the migration of the 2 gonadal distal tip cells (DTCs) (By similarity). Belongs to the CRK family. (277 aa)
CBG13654Protein CBG13654. (280 aa)
sorf-1Protein CBG14197. (239 aa)
rab-37Protein CBR-RAB-37. (238 aa)
tom-1Protein CBR-TOM-1. (1101 aa)
ced-10Protein CBG15031. (191 aa)
snt-2Protein CBR-SNT-2. (370 aa)
lec-6Galectin. (146 aa)
stim-1Protein CBR-STIM-1. (550 aa)
toca-1Protein CBR-TOCA-1. (588 aa)
rbf-1Protein CBR-RBF-1. (1021 aa)
CBG16580Protein CBG16580. (221 aa)
sdpn-1Protein CBR-SDPN-1. (485 aa)
CBG16900Protein CBG16900. (944 aa)
gcy-9Guanylate cyclase. (1156 aa)
esyt-2Protein CBR-ESYT-2. (728 aa)
CBG17467Protein CBG17467. (594 aa)
CBG17621Protein CBG17621. (62 aa)
pdr-1E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (385 aa)
toca-2Protein CBR-TOCA-2. (677 aa)
cnt-2Protein CBR-CNT-2. (1161 aa)
gipc-2Protein CBG17992. (363 aa)
sel-5Protein CBR-SEL-5. (1078 aa)
wve-1Protein CBR-WVE-1. (475 aa)
CBG18798Protein CBG18798. (813 aa)
mrck-1Protein CBR-MRCK-1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1586 aa)
gras-1Protein CBG23728. (245 aa)
snt-6Protein CBR-SNT-6. (465 aa)
sorf-2Protein CBG24676. (1417 aa)
arf-6Protein CBR-ARF-6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
itsn-1Protein CBR-ITSN-1. (1099 aa)
dab-1Protein CBR-DAB-1. (483 aa)
sar-1Protein CBG01701; Belongs to the small GTPase superfamily. SAR1 family. (193 aa)
gex-2Protein CBR-GEX-2. (1278 aa)
CBG01565Protein CBG01565. (188 aa)
wsp-1Protein CBR-WSP-1. (785 aa)
CBG02083Protein CBG02083. (761 aa)
CBG02097Protein CBG02097. (218 aa)
ndk-1Nucleoside diphosphate kinase. (153 aa)
CBG03272Protein CBG03272. (321 aa)
CBG03052Protein CBG03052. (74 aa)
ccm-3Protein CBG03050. (215 aa)
CBG02956Protein CBG02956. (196 aa)
rga-1Protein CBR-RGA-1. (439 aa)
CBG02513Protein CBG02513. (322 aa)
CBG02510Protein CBG02510. (343 aa)
tbc-2Protein CBG02508. (944 aa)
rab-3Protein CBR-RAB-3. (219 aa)
pld-1Phospholipase. (1402 aa)
gex-3Protein CBR-GEX-3. (1140 aa)
mca-3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1159 aa)
mom-5Protein CBR-MOM-5; Belongs to the G-protein coupled receptor Fz/Smo family. (570 aa)
CBG04368Protein CBG04368. (285 aa)
abl-1Tyrosine-protein kinase. (1211 aa)
unc-112Protein CBR-UNC-112. (720 aa)
srgp-1Protein CBR-SRGP-1. (1060 aa)
CBG05923Protein CBG05923. (1233 aa)
cla-1Protein CBR-TAG-199. (2352 aa)
snt-5Protein CBR-SNT-5. (457 aa)
snt-3Protein CBR-SNT-3. (284 aa)
pat-2Integrin alpha pat-2; Required for muscle development probably through the regulation of the actin-myosin cytoskeleton. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52. Required for distal tip cell migration and dorsal pathfinding. Required for egg-laying. May play a role in cell motility and cell-cell interactions. (1224 aa)
piki-1Protein CBR-PIKI-1; Belongs to the PI3/PI4-kinase family. (1680 aa)
snt-7Protein CBR-SNT-7. (414 aa)
gsk-3Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting [...] (359 aa)
aex-6Protein CBR-AEX-6. (215 aa)
CBG08107Protein CBG08107. (328 aa)
jph-1Protein CBR-JPH-1. (755 aa)
ced-5Protein CBR-CED-5; Belongs to the DOCK family. (1820 aa)
CBG08577Protein CBG08577. (331 aa)
syx-4Protein CBR-SYX-4; Belongs to the syntaxin family. (293 aa)
abi-1Protein CBR-ABI-1. (487 aa)
ced-6Protein CBR-CED-6. (490 aa)
cup-5Protein CBR-CUP-5. (650 aa)
mtm-3Protein CBR-MTM-3. (1008 aa)
cash-1Protein CBR-CASH-1. (681 aa)
uig-1Protein CBR-UIG-1. (941 aa)
chc-1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1660 aa)
ced-7Protein CBR-CED-7. (1784 aa)
mtm-1Protein CBR-MTM-1. (590 aa)
sng-1Synaptogyrin. (248 aa)
sphk-1Protein CBR-SPHK-1. (423 aa)
snt-1Protein CBR-SNT-1. (443 aa)
swan-1Protein CBR-SWAN-1. (386 aa)
gck-1Protein CBR-GCK-1. (898 aa)
CBG19188Protein CBG19188. (309 aa)
unc-41Protein CBR-UNC-41. (1661 aa)
CBG19476Protein CBG19476. (106 aa)
CBG19737Protein CBG19737. (2438 aa)
bec-1Protein CBR-BEC-1. (375 aa)
sand-1Protein CBR-SAND-1. (460 aa)
CBG19958Protein CBG19958. (572 aa)
snpn-1Protein CBG19979. (123 aa)
pph-5Protein CBR-PPH-5. (496 aa)
CBG20803Protein CBG20803. (633 aa)
rab-7Protein CBR-RAB-7. (209 aa)
cnt-1Protein CBR-CNT-1. (824 aa)
CBG21499Protein CBG21499. (446 aa)
rap-1Protein CBR-RAP-1. (188 aa)
CBG22081Protein CBG22081. (146 aa)
vps-34Phosphatidylinositol 3-kinase catalytic subunit type 3. (895 aa)
CBG22220Protein CBG22220. (566 aa)
CBG22536Protein CBG22536. (330 aa)
CBG22703Protein CBG22703. (914 aa)
CBG23228Protein CBG23228. (546 aa)
CBG26388Protein CBG26388. (223 aa)
CBG04367Protein CBG04367. (662 aa)
CBG18752Protein CBG18752. (566 aa)
CBG19771Protein CBG19771. (796 aa)
tat-1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1218 aa)
rme-8Protein CBR-RME-8, isoform a. (2341 aa)
nrf-5Protein CBR-NRF-5. (544 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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