STRINGSTRING
mig-14 mig-14 dyf-11 dyf-11 CBG13515 CBG13515 CBG22319 CBG22319 CBG20780 CBG20780 CBG09173 CBG09173 mig-5 mig-5 ska-1 ska-1 pab-1 pab-1 szy-20 szy-20 ebp-2 ebp-2 dsh-1 dsh-1 dsh-2 dsh-2 mom-5 mom-5 tac-1 tac-1 bicd-1 bicd-1 ebp-1 ebp-1 pab-2 pab-2 gsk-3 gsk-3 apr-1 apr-1 spat-1 spat-1 unc-44.2 unc-44.2 unc-44.1 unc-44.1 unc-6 unc-6 efa-6 efa-6 atat-2 atat-2 unc-33 unc-33 ced-10 ced-10 exc-6 exc-6 ptrn-1 ptrn-1 mig-2 mig-2 mec-17 mec-17 klp-7 klp-7 atx-2 atx-2 zyg-8 zyg-8 maph-1.1 maph-1.1 unc-5 unc-5 kin-19 kin-19
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mig-14Protein CBR-MIG-14. (548 aa)
dyf-11Protein CBR-DYF-11. (406 aa)
CBG13515Protein CBG13515. (589 aa)
CBG22319Protein CBG22319. (306 aa)
CBG20780Protein CBG20780. (218 aa)
CBG09173Protein CLASP-1; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules; Belongs to the CLASP family. (1333 aa)
mig-5Protein CBR-MIG-5. (657 aa)
ska-1Spindle and kinetochore-associated protein 1 homolog; Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtu [...] (239 aa)
pab-1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (666 aa)
szy-20Protein CBR-SZY-20. (514 aa)
ebp-2Protein CBR-EBP-2. (306 aa)
dsh-1Protein CBR-DSH-1. (1129 aa)
dsh-2Protein CBR-DSH-2. (784 aa)
mom-5Protein CBR-MOM-5; Belongs to the G-protein coupled receptor Fz/Smo family. (570 aa)
tac-1Protein CBR-TAC-1. (262 aa)
bicd-1Protein CBR-BICD-1. (834 aa)
ebp-1Protein CBR-EBP-1. (303 aa)
pab-2Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (685 aa)
gsk-3Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting [...] (359 aa)
apr-1APC-related protein 1; Has a role in endoderm cell specification and pharyngeal development. Required for the migration of epithelial cells, organization of the anterior seam cells and ceh-13 expression during embryo morphogenesis. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation. During larval development, apr-1 is required for expression of lin-39 in P3-8.p. Shown to negatively regulate Wnt signaling in vulval precursor cells. Has a role in cell division by establishing the polarity of the mother cel [...] (1171 aa)
spat-1Protein CBR-SPAT-1. (542 aa)
unc-44.2Protein CBG09473. (5237 aa)
unc-44.1Protein CBG09456. (1857 aa)
unc-6Protein CBR-UNC-6. (621 aa)
efa-6Protein CBR-EFA-6. (836 aa)
atat-2Alpha-tubulin N-acetyltransferase 2; Specifically acetylates 'Lys-40' in alpha-tubulin/mec-12 on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act [...] (263 aa)
unc-33Protein CBR-UNC-33. (862 aa)
ced-10Protein CBG15031. (191 aa)
exc-6Protein CBR-INFT-1. (901 aa)
ptrn-1Protein CBR-PQN-34. (1099 aa)
mig-2Protein CBR-MIG-2. (195 aa)
mec-17Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin/mec-12 on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act [...] (277 aa)
klp-7Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (743 aa)
atx-2Protein CBR-ATX-2. (1051 aa)
zyg-8Protein CBR-ZYG-8. (822 aa)
maph-1.1Protein CBG19716. (912 aa)
unc-5Protein CBR-UNC-5. (922 aa)
kin-19Protein CBR-KIN-19; Belongs to the protein kinase superfamily. (342 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.