STRINGSTRING
ced-7 ced-7 mom-2 mom-2 ced-10 ced-10 hmp-2 hmp-2 mig-14 mig-14 src-1 src-1 CBG26388 CBG26388 mig-5 mig-5 wrm-1 wrm-1 ced-5 ced-5 gsk-3 gsk-3 mom-5 mom-5 egl-20 egl-20 dsh-2 dsh-2 ced-6 ced-6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ced-7Protein CBR-CED-7. (1784 aa)
mom-2Protein CBR-MOM-2. (358 aa)
ced-10Protein CBG15031. (191 aa)
hmp-2Protein CBR-HMP-2. (686 aa)
mig-14Protein CBR-MIG-14. (548 aa)
src-1Tyrosine-protein kinase. (544 aa)
CBG26388Protein CBG26388. (223 aa)
mig-5Protein CBR-MIG-5. (657 aa)
wrm-1Armadillo repeat-containing protein wrm-1; Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1- dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome [...] (799 aa)
ced-5Protein CBR-CED-5; Belongs to the DOCK family. (1820 aa)
gsk-3Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting [...] (359 aa)
mom-5Protein CBR-MOM-5; Belongs to the G-protein coupled receptor Fz/Smo family. (570 aa)
egl-20Protein CBR-EGL-20. (398 aa)
dsh-2Protein CBR-DSH-2. (784 aa)
ced-6Protein CBR-CED-6. (490 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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