STRINGSTRING
CBG25094 CBG25094 pif-1 pif-1 ruvb-2 ruvb-2 CBG07262 CBG07262 CBG07261 CBG07261 smg-2 smg-2 CBG08616 CBG08616 CBG09120 CBG09120 chd-1 chd-1 mcm-3 mcm-3 CBG11900 CBG11900 mcm-5 mcm-5 CBG12752 CBG12752 cku-70 cku-70 xpb-1 xpb-1 top-3 top-3 twnk-1 twnk-1 helq-1 helq-1 xpd-1 xpd-1 CBG18388 CBG18388 chl-1 chl-1 cku-80 cku-80 CBG18156 CBG18156 mcm-2 mcm-2 ruvb-1 ruvb-1 dog-1 dog-1 rcq-5 rcq-5 top-1 top-1 CBG21297 CBG21297 him-6 him-6 CBG21674 CBG21674 mcm-7 mcm-7 xnp-1 xnp-1 CBG22691 CBG22691 CBG22989 CBG22989 rad-50 rad-50 CBG28108 CBG28108 CBG26504 CBG26504 CBG20786 CBG20786 CBG20144 CBG20144 CBG04254 CBG04254 CBG24699 CBG24699 rpa-1 rpa-1 mcm-6 mcm-6 CBG06022 CBG06022 CBG23571 CBG23571 gtf-2f2 gtf-2f2 CBG24191 CBG24191 Cbr-dct-10 Cbr-dct-10 CBG24757 CBG24757 rtel-1 rtel-1 Cbr-rha-1 Cbr-rha-1 dna-2 dna-2 top-2 top-2 wrn-1 wrn-1 ctf-18 ctf-18 CBG03544 CBG03544 morc-1 morc-1 CBG03690 CBG03690 CBG03697 CBG03697 mcm-4 mcm-4 CBG04249 CBG04249 CBG04252 CBG04252 CBG04253 CBG04253
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBG25094Protein CBG25094. (323 aa)
pif-1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (683 aa)
ruvb-2RuvB-like helicase; Belongs to the RuvB family. (447 aa)
CBG07262ATP-dependent DNA helicase; Belongs to the helicase family. (494 aa)
CBG07261ATP-dependent DNA helicase; Belongs to the helicase family. (472 aa)
smg-2Protein CBR-SMG-2. (1051 aa)
CBG08616Protein CBG08616. (86 aa)
CBG09120Protein CBG09120. (380 aa)
chd-1Protein CBR-CHD-1. (1465 aa)
mcm-3Protein CBR-MCM-3; Belongs to the MCM family. (812 aa)
CBG11900ATP-dependent DNA helicase; Belongs to the helicase family. (523 aa)
mcm-5DNA helicase; Belongs to the MCM family. (771 aa)
CBG12752Protein CBG12752. (546 aa)
cku-70Protein CBR-CKU-70. (680 aa)
xpb-1Protein CBG13269. (800 aa)
top-3DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (774 aa)
twnk-1Protein CBG14751. (534 aa)
helq-1Protein CBG15258. (913 aa)
xpd-1Protein CBG15713. (755 aa)
CBG18388Protein CBG18388. (995 aa)
chl-1Protein CBR-CHL-1. (834 aa)
cku-80ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (720 aa)
CBG18156DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1207 aa)
mcm-2DNA helicase; Belongs to the MCM family. (892 aa)
ruvb-1RuvB-like helicase; Belongs to the RuvB family. (478 aa)
dog-1Protein CBR-DOG-1. (885 aa)
rcq-5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (831 aa)
top-1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (840 aa)
CBG21297Protein CBG21297. (519 aa)
him-6Protein CBR-HIM-6. (1005 aa)
CBG21674Protein CBG21674. (171 aa)
mcm-7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (729 aa)
xnp-1Protein CBR-XNP-1. (1333 aa)
CBG22691Protein CBG22691. (390 aa)
CBG22989Protein CBG22989. (289 aa)
rad-50Protein CBR-RAD-50. (1354 aa)
CBG28108Protein CBG28108. (74 aa)
CBG26504Protein CBG26504. (279 aa)
CBG20786DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (591 aa)
CBG20144Protein CBG20144. (435 aa)
CBG04254Protein CBG04254. (80 aa)
CBG24699Protein CBG24699. (319 aa)
rpa-1Probable replication factor A 73 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (658 aa)
mcm-6DNA replication licensing factor mcm-6; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentia [...] (810 aa)
CBG06022ATP-dependent RNA helicase SUV3 homolog, mitochondrial; ATPase and DNA/RNA helicase able to unwind DNA/DNA, DNA/RNA and RNA/RNA duplexes in the 5'-3' direction. (721 aa)
CBG23571Protein CBG23571. (1136 aa)
gtf-2f2Protein CBG23703. (236 aa)
CBG24191Putative ATP-dependent DNA helicase Q1; DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). (618 aa)
Cbr-dct-10Protein CBR-DCT-10. (2032 aa)
CBG24757Protein CBG24757. (616 aa)
rtel-1Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. (994 aa)
Cbr-rha-1Protein CBR-RHA-1. (1402 aa)
dna-2Protein CBR-DNA-2. (1123 aa)
top-2DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1482 aa)
wrn-1Protein CBR-WRN-1. (1061 aa)
ctf-18Protein CBG03417. (840 aa)
CBG03544Protein CBG03544. (474 aa)
morc-1Protein CBR-MORC-1. (870 aa)
CBG03690Protein CBG03690. (183 aa)
CBG03697Protein CBG03697. (249 aa)
mcm-4DNA helicase; Belongs to the MCM family. (830 aa)
CBG04249Protein CBG04249. (513 aa)
CBG04252Protein CBG04252. (779 aa)
CBG04253Protein CBG04253. (2026 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.