STRINGSTRING
tax-2 tax-2 exc-5 exc-5 arx-4 arx-4 unc-69 unc-69 unc-51 unc-51 CBG24636 CBG24636 sorf-2 sorf-2 ttx-3 ttx-3 fli-1 fli-1 exc-7 exc-7 gex-2 gex-2 pmk-3 pmk-3 CBG02114 CBG02114 hlh-3 hlh-3 CBG03256 CBG03256 cap-2 cap-2 npp-5 npp-5 vhp-1 vhp-1 unc-94 unc-94 viln-1 viln-1 arx-7 arx-7 pfn-1 pfn-1 kcc-2 kcc-2 let-653 let-653 cap-1 cap-1 kcc-1 kcc-1 CBG05768 CBG05768 daam-1 daam-1 CBG06442 CBG06442 unc-60 unc-60 CBG06893 CBG06893 tax-4 tax-4 CBG07084 CBG07084 exc-1 exc-1 kin-20 kin-20 slt-1 slt-1 let-4 let-4 sad-1 sad-1 CBG07290 CBG07290 CBG07288 CBG07288 CBG07267 CBG07267 prx-11 prx-11 pfn-3 pfn-3 CBG08400 CBG08400 mlk-1 mlk-1 sma-4 sma-4 cyk-3 cyk-3 spe-10 spe-10 CBG10613 CBG10613 zag-1 zag-1 CBG10797 CBG10797 unc-104 unc-104 swan-1 swan-1 tmd-2 tmd-2 unc-76 unc-76 smp-2 smp-2 unc-73 unc-73 cas-2 cas-2 let-607 let-607 CBG13014 CBG13014 kcc-3 kcc-3 CBG13067 CBG13067 vps-18 vps-18 efa-6 efa-6 eps-8 eps-8 mak-2 mak-2 spc-1 spc-1 sorf-1 sorf-1 unc-78 unc-78 add-1 add-1 CBG14652 CBG14652 CBG14672 CBG14672 CBG14863 CBG14863 unc-40 unc-40 cav-1 cav-1 exc-6 exc-6 CBG15341 CBG15341 arx-5 arx-5 twf-2 twf-2 sma-5 sma-5 sma-3 sma-3 mek-1 mek-1 adt-2 adt-2 dbn-1 dbn-1 arx-6 arx-6 ppm-2 ppm-2 arx-3 arx-3 fsn-1 fsn-1 Cbr-nkcc-1 Cbr-nkcc-1 tfg-1 tfg-1 dbl-1 dbl-1 unc-70 unc-70 glo-4 glo-4 gsnl-1 gsnl-1 let-756 let-756 exc-4 exc-4 smp-1 smp-1 bec-1 bec-1 unc-5 unc-5 CBG20438 CBG20438 vab-19 vab-19 crml-1 crml-1 rig-6 rig-6 rab-7 rab-7 vha-19 vha-19 CBG21788 CBG21788 icln-1 icln-1 vps-34 vps-34 ceh-17 ceh-17 rga-5 rga-5 aipl-1 aipl-1 CBG23464 CBG23464 add-2 add-2 sma-1 sma-1 daf-11 daf-11 CBG13515 CBG13515 CBG26382 CBG26382 CBG26357 CBG26357 unc-53 unc-53 mab-20 mab-20 ced-4 ced-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tax-2Protein CBR-TAX-2. (810 aa)
exc-5Protein CBR-EXC-5. (859 aa)
arx-4Protein CBR-ARX-4. (539 aa)
unc-69Protein CBR-UNC-69. (108 aa)
unc-51Protein CBR-UNC-51. (875 aa)
CBG24636Protein CBG24636. (770 aa)
sorf-2Protein CBG24676. (1417 aa)
ttx-3Protein CBR-TTX-3. (380 aa)
fli-1Protein CBR-FLI-1. (1271 aa)
exc-7Protein CBR-EXC-7. (676 aa)
gex-2Protein CBR-GEX-2. (1278 aa)
pmk-3Mitogen-activated protein kinase. (466 aa)
CBG02114Protein CBG02114. (114 aa)
hlh-3Protein CBR-HLH-3. (168 aa)
CBG03256Protein CBG03256. (972 aa)
cap-2F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (271 aa)
npp-5Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (827 aa)
vhp-1Protein CBR-VHP-1. (672 aa)
unc-94Protein CBR-UNC-94. (406 aa)
viln-1Protein CBG03958. (901 aa)
arx-7Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (152 aa)
pfn-1Profilin; Belongs to the profilin family. (132 aa)
kcc-2Protein CBR-KCC-3. (973 aa)
let-653Protein CBR-LET-653. (736 aa)
cap-1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (282 aa)
kcc-1Protein CBR-KCC-1. (1109 aa)
CBG05768Protein CBG05768. (330 aa)
daam-1Protein CBR-DAAM-1. (862 aa)
CBG06442Protein CBG06442. (210 aa)
unc-60Protein CBR-UNC-60; Belongs to the actin-binding proteins ADF family. (293 aa)
CBG06893Protein CBG06893. (157 aa)
tax-4Protein CBR-TAX-4. (726 aa)
CBG07084Protein CBG07084. (959 aa)
exc-1Protein CBG07708. (760 aa)
kin-20Protein CBR-KIN-20; Belongs to the protein kinase superfamily. (490 aa)
slt-1Protein CBR-SLT-1. (1376 aa)
let-4Protein CBR-SYM-5. (781 aa)
sad-1Protein CBR-SAD-1. (931 aa)
CBG07290Protein CBG07290. (348 aa)
CBG07288Protein CBG07288. (379 aa)
CBG07267Protein CBG07267. (315 aa)
prx-11Protein CBR-PRX-11. (214 aa)
pfn-3Profilin; Belongs to the profilin family. (114 aa)
CBG08400Protein CBG08400. (668 aa)
mlk-1Protein CBR-MLK-1. (1091 aa)
sma-4Dwarfin sma. (603 aa)
cyk-3Protein CBR-CYK-3. (1190 aa)
spe-10Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (365 aa)
CBG10613Protein CBG10613. (292 aa)
zag-1Protein CBR-ZAG-1. (618 aa)
CBG10797Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (215 aa)
unc-104Protein CBR-UNC-104; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1699 aa)
swan-1Protein CBR-SWAN-1. (386 aa)
tmd-2Protein CBR-TMD-2. (641 aa)
unc-76Protein CBR-UNC-76. (232 aa)
smp-2Protein CBR-SMP-2; Belongs to the semaphorin family. (689 aa)
unc-73Protein CBR-UNC-73. (1618 aa)
cas-2Adenylyl cyclase-associated protein; Belongs to the CAP family. (468 aa)
let-607Protein CBR-LET-607. (686 aa)
CBG13014Protein CBG13014. (318 aa)
kcc-3Protein CBR-KCC-2. (1100 aa)
CBG13067Protein CBG13067. (625 aa)
vps-18Protein CBG13485. (940 aa)
efa-6Protein CBR-EFA-6. (836 aa)
eps-8Protein CBR-EPS-8. (918 aa)
mak-2Protein CBR-MAK-2; Belongs to the protein kinase superfamily. (366 aa)
spc-1Protein CBR-SPC-1. (2467 aa)
sorf-1Protein CBG14197. (239 aa)
unc-78Protein CBR-UNC-78. (611 aa)
add-1Protein CBR-ADD-1. (804 aa)
CBG14652Protein CBG14652. (299 aa)
CBG14672Profilin; Belongs to the profilin family. (131 aa)
CBG14863Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa)
unc-40Protein CBR-UNC-40. (1407 aa)
cav-1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (239 aa)
exc-6Protein CBR-INFT-1. (901 aa)
CBG15341Protein CBG15341. (937 aa)
arx-5Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa)
twf-2Protein CBG16364. (376 aa)
sma-5Protein CBR-SMA-5; Belongs to the protein kinase superfamily. (491 aa)
sma-3Dwarfin sma. (365 aa)
mek-1Protein CBR-MEK-1. (463 aa)
adt-2Protein CBR-ADT-2. (1065 aa)
dbn-1Protein CBG18266. (672 aa)
arx-6Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (169 aa)
ppm-2Protein CBG18025. (352 aa)
arx-3Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (382 aa)
fsn-1F-box/SPRY domain-containing protein 1; Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf-2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM and [...] (332 aa)
Cbr-nkcc-1Protein CBR-NKCC-1. (1191 aa)
tfg-1Protein CBR-TFG-1. (513 aa)
dbl-1Protein CBR-DBL-1. (373 aa)
unc-70Spectrin beta chain; Belongs to the spectrin family. (2370 aa)
glo-4Protein CBR-GLO-4. (1392 aa)
gsnl-1Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. (474 aa)
let-756Protein CBR-LET-756; Belongs to the heparin-binding growth factors family. (473 aa)
exc-4Protein CBR-EXC-4. (291 aa)
smp-1Protein CBR-SMP-1; Belongs to the semaphorin family. (714 aa)
bec-1Protein CBR-BEC-1. (375 aa)
unc-5Protein CBR-UNC-5. (922 aa)
CBG20438Protein CBG20438. (110 aa)
vab-19Protein CBR-VAB-19. (1059 aa)
crml-1Protein CBR-CRML-1. (1054 aa)
rig-6Protein CBR-RIG-6. (1297 aa)
rab-7Protein CBR-RAB-7. (209 aa)
vha-19Protein CBR-VHA-19. (453 aa)
CBG21788Protein CBG21788. (870 aa)
icln-1Protein CBR-ICLN-1. (228 aa)
vps-34Phosphatidylinositol 3-kinase catalytic subunit type 3. (895 aa)
ceh-17Protein CBR-CEH-17. (234 aa)
rga-5Protein CBR-RGA-5. (1327 aa)
aipl-1Protein CBR-TAG-216. (599 aa)
CBG23464Protein CBG23464. (800 aa)
add-2Protein CBR-ADD-2. (630 aa)
sma-1Protein CBR-SMA-1. (4156 aa)
daf-11Guanylate cyclase. (1277 aa)
CBG13515Protein CBG13515. (589 aa)
CBG26382Protein CBG26382. (95 aa)
CBG26357Protein CBG26357. (148 aa)
unc-53Protein CBR-UNC-53, isoform a. (1778 aa)
mab-20Semaphorin-2A; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting and allows the formation of distinct sensory rays. Seems to control cell-cell contact formation through 2 parallel pathways, one involving efn-4 and one involving plx-2 and unc-129. Involved in axon guidance. Probably by binding receptor plx-2, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus [...] (656 aa)
ced-4Cell death protein 4; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to induce caspase ced-3 autoproteolytic cleavage and activation. Also forms an holoenzyme with processed ced-3 enhancing ced-3 activity. Component of the egl-1, ced-9, ced-4 and ced- 3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During [...] (569 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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