(22 nodes) Nuclear cyclin-dependent protein kinase holoenzyme complex network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ccnk-1	Protein CBG04574; Belongs to the cyclin family. (260 aa)
	CBG04848	Protein CBG04848. (366 aa)
	CBG04906	Protein CBG04906; Belongs to the protein kinase superfamily. Tyr protein kinase family. (458 aa)
	CBG04907	Protein CBG04907. (385 aa)
	CBG04908	Protein CBG04908. (372 aa)
	CBG04913	Protein CBG04913. (401 aa)
	kin-15	Protein CBR-KIN-15; Belongs to the protein kinase superfamily. Tyr protein kinase family. (506 aa)
	kin-16	Protein CBR-KIN-16; Belongs to the protein kinase superfamily. Tyr protein kinase family. (501 aa)
	CBG15591	Protein CBG15591. (344 aa)
	CBG15589	Protein CBG15589. (512 aa)
	CBG15501	Protein CBG15501. (583 aa)
	CBG17534	Protein CBG17534. (573 aa)
	CBG17535	Receptor protein-tyrosine kinase. (1447 aa)
	ver-3	Protein CBR-VER-3. (1313 aa)
	cdk-12	Protein CBR-CDTL-7. (642 aa)
	cdk-9	Protein CBR-CDK-9; Belongs to the protein kinase superfamily. (464 aa)
	CBG22965	Protein CBG22965. (281 aa)
	cit-1.1	Protein CBR-CIT-1.1. (161 aa)
	cit-1.2	Protein CBR-CIT-1.2. (792 aa)
	CBG27553	Protein CBG27553. (89 aa)
	CBG25972	Protein CBG25972. (66 aa)
	cic-1	Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase cdk-8 that phosphoryl [...] (298 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG15501	CBG15589	A8XM70	A8XM32	Protein CBG15501.	Protein CBG15589.	0.701
CBG15501	CBG15591	A8XM70	A8XM31	Protein CBG15501.	Protein CBG15591.	0.768
CBG15501	CBG25972	A8XM70	B6IKS2	Protein CBG15501.	Protein CBG25972.	0.701
CBG15501	ccnk-1	A8XM70	A8WXY8	Protein CBG15501.	Protein CBG04574; Belongs to the cyclin family.	0.534
CBG15501	cdk-12	A8XM70	A8XT06	Protein CBG15501.	Protein CBR-CDTL-7.	0.787
CBG15501	cdk-9	A8XM70	A8XXR0	Protein CBG15501.	Protein CBR-CDK-9; Belongs to the protein kinase superfamily.	0.885
CBG15501	cic-1	A8XM70	P0C654	Protein CBG15501.	Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase cdk-8 that phosphoryl [...]	0.557
CBG15589	CBG15501	A8XM32	A8XM70	Protein CBG15589.	Protein CBG15501.	0.701
CBG15589	CBG15591	A8XM32	A8XM31	Protein CBG15589.	Protein CBG15591.	0.567
CBG15589	CBG22965	A8XM32	A8Y3K0	Protein CBG15589.	Protein CBG22965.	0.701
CBG15589	ccnk-1	A8XM32	A8WXY8	Protein CBG15589.	Protein CBG04574; Belongs to the cyclin family.	0.701
CBG15589	cdk-9	A8XM32	A8XXR0	Protein CBG15589.	Protein CBR-CDK-9; Belongs to the protein kinase superfamily.	0.554
CBG15589	cit-1.1	A8XM32	A8Y3K1	Protein CBG15589.	Protein CBR-CIT-1.1.	0.701
CBG15589	cit-1.2	A8XM32	A8Y3K2	Protein CBG15589.	Protein CBR-CIT-1.2.	0.701
CBG15591	CBG15501	A8XM31	A8XM70	Protein CBG15591.	Protein CBG15501.	0.768
CBG15591	CBG15589	A8XM31	A8XM32	Protein CBG15591.	Protein CBG15589.	0.567
CBG15591	CBG22965	A8XM31	A8Y3K0	Protein CBG15591.	Protein CBG22965.	0.768
CBG15591	CBG25972	A8XM31	B6IKS2	Protein CBG15591.	Protein CBG25972.	0.516
CBG15591	ccnk-1	A8XM31	A8WXY8	Protein CBG15591.	Protein CBG04574; Belongs to the cyclin family.	0.869
CBG15591	cdk-12	A8XM31	A8XT06	Protein CBG15591.	Protein CBR-CDTL-7.	0.694