STRINGSTRING
nkb-1 nkb-1 nkb-2 nkb-2 CBG04600 CBG04600 best-9 best-9 unc-80 unc-80 pgp-9 pgp-9 CBG06101 CBG06101 best-7.1 best-7.1 egl-19 egl-19 ucr-2.3 ucr-2.3 best-7.2 best-7.2 lpd-5 lpd-5 amt-2 amt-2 CBG24154 CBG24154 zipt-7.1 zipt-7.1 amt-3 amt-3 shk-1 shk-1 micu-1 micu-1 nd1 nd1 best-16 best-16 CBG05768 CBG05768 icl-1 icl-1 nuo-5 nuo-5 CBG06677 CBG06677 tax-4 tax-4 best-3 best-3 best-4 best-4 CBG01548 CBG01548 gas-1 gas-1 zipt-7.2 zipt-7.2 emre-1 emre-1 ucr-2.2 ucr-2.2 CBG07404 CBG07404 acr-9 acr-9 nkb-3 nkb-3 irk-2 irk-2 CBG08243 CBG08243 cubn-1 cubn-1 molo-1 molo-1 lgc-50 lgc-50 kvs-2 kvs-2 best-14 best-14 mcu-1 mcu-1 exp-2 exp-2 best-18 best-18 best-5 best-5 irk-3 irk-3 CBG10746 CBG10746 best-20 best-20 nuo-6 nuo-6 unc-2 unc-2 CBG11518 CBG11518 cng-1 cng-1 ccb-1 ccb-1 sol-1 sol-1 tax-2 tax-2 nduf-7 nduf-7 CBG12806 CBG12806 nuo-2 nuo-2 CBG12982 CBG12982 glc-4 glc-4 pgp-11 pgp-11 CBG13503 CBG13503 best-21 best-21 amt-1 amt-1 neto-1 neto-1 CBG15263 CBG15263 best-17 best-17 Cbr-tag-266 Cbr-tag-266 trp-2 trp-2 stg-2 stg-2 CBG02060 CBG02060 ucr-2.1 ucr-2.1 unc-36 unc-36 kvs-1 kvs-1 cng-2 cng-2 cca-1 cca-1 best-15 best-15 kvs-4 kvs-4 glr-1 glr-1 best-23 best-23 nuo-1 nuo-1 Cbr-tag-180 Cbr-tag-180 stg-1 stg-1 abch-1 abch-1 mps-1 mps-1 CBG02478 CBG02478 nmr-1 nmr-1 best-22 best-22 best-13 best-13 ccb-2 ccb-2 ctb-1 ctb-1 nd4l nd4l CBG03233 CBG03233 orai-1 orai-1 eat-2 eat-2 CBG29118 CBG29118 amt-4.1 amt-4.1 CBG26024 CBG26024 CBG28046 CBG28046 CBG23138 CBG23138 CBG22517 CBG22517 atm-1 atm-1 CBG22013 CBG22013 CBG25106 CBG25106 nuo-3 nuo-3 cua-1 cua-1 ras-1 ras-1 CBG20772 CBG20772 CBG20679 CBG20679 glc-2 glc-2 nduf-9 nduf-9 Cbr-unc-103.1 Cbr-unc-103.1 CBG20020 CBG20020 sol-2 sol-2 exc-4 exc-4 nduf-2.2 nduf-2.2 kvs-3 kvs-3 mod-1 mod-1 best-8 best-8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nkb-1Protein CBR-NKB-1. (319 aa)
nkb-2Protein CBR-NKB-2. (378 aa)
CBG04600Protein CBG04600. (262 aa)
best-9Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (399 aa)
unc-80Protein CBR-UNC-80. (3520 aa)
pgp-9Protein CBR-PGP-9. (1348 aa)
CBG06101Protein CBG06101. (210 aa)
best-7.1Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (533 aa)
egl-19Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1780 aa)
ucr-2.3Protein CBR-UCR-2.3. (433 aa)
best-7.2Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (541 aa)
lpd-5Protein CBR-LPD-5. (176 aa)
amt-2Ammonium transporter. (507 aa)
CBG24154Protein CBG24154. (212 aa)
zipt-7.1Zinc transporter zipt-7.1; Zinc transporter which regulates intracellular zinc levels (By similarity). Required for spermatogenesis in both hermaphrodites and males where it resides in an inactive form in immature sperm, spermatids, but is likely activated in response to reduced spe-4 and spe-6 function (By similarity). Upon activation, mediates the release of zinc from internal stores in spermatids into the cytoplasm (By similarity). The resulting increase in cytoplasmic zinc levels promotes spermatid activation and subsequent differentiation into mature motile sperm that are capable [...] (392 aa)
amt-3Ammonium transporter. (704 aa)
shk-1Protein CBG01037; Belongs to the potassium channel family. (490 aa)
micu-1Calcium uptake protein 1 homolog, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU). Belongs to the MICU1 family. MICU1 subfamily. (533 aa)
nd1NADH-ubiquinone oxidoreductase chain 1; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (291 aa)
best-16Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (406 aa)
CBG05768Protein CBG05768. (330 aa)
icl-1Malate synthase; Belongs to the malate synthase family. (975 aa)
nuo-5Protein CBR-NUO-5; Belongs to the complex I 75 kDa subunit family. (725 aa)
CBG06677Protein CBG06677. (456 aa)
tax-4Protein CBR-TAX-4. (726 aa)
best-3Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (612 aa)
best-4Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (561 aa)
CBG01548Protein CBG01548. (177 aa)
gas-1Protein CBR-GAS-1; Belongs to the complex I 49 kDa subunit family. (482 aa)
zipt-7.2Zinc transporter zipt-7.2; Zinc transporter; Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. (476 aa)
emre-1Protein CBR-TAG-299. (91 aa)
ucr-2.2Protein CBR-UCR-2.2. (483 aa)
CBG07404Protein CBG07404. (214 aa)
acr-9Protein CBR-ACR-9. (548 aa)
nkb-3Probable sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Implicated in genomic response to various soil bacteria that affects fitness, lifespan and brood size (By similarity). (326 aa)
irk-2Protein CBR-IRK-2. (531 aa)
CBG08243Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (594 aa)
cubn-1Protein CBG08530. (4039 aa)
molo-1Protein CBG08983. (289 aa)
lgc-50Protein CBR-LGC-50; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (448 aa)
kvs-2Protein CBG09661; Belongs to the potassium channel family. (589 aa)
best-14Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (363 aa)
mcu-1Protein CBR-MCU-1. (333 aa)
exp-2Protein CBR-EXP-2; Belongs to the potassium channel family. (531 aa)
best-18Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (454 aa)
best-5Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (469 aa)
irk-3Protein CBR-IRK-3. (369 aa)
CBG10746Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (73 aa)
best-20Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (360 aa)
nuo-6Protein CBR-NUO-6. (172 aa)
unc-2Protein CBR-UNC-2. (1536 aa)
CBG11518Protein CBG11518. (239 aa)
cng-1Protein CBR-CNG-1. (682 aa)
ccb-1Protein CBR-CCB-1. (523 aa)
sol-1Protein CBR-SOL-1. (596 aa)
tax-2Protein CBR-TAX-2. (810 aa)
nduf-7Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (199 aa)
CBG12806Protein CBG12806. (171 aa)
nuo-2Protein CBR-NUO-2; Belongs to the complex I 30 kDa subunit family. (399 aa)
CBG12982Protein CBG12982. (314 aa)
glc-4Protein CBR-GLC-4; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (548 aa)
pgp-11Protein CBR-PGP-11. (1209 aa)
CBG13503Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (533 aa)
best-21Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (387 aa)
amt-1Ammonium transporter. (534 aa)
neto-1Protein CBG14955. (334 aa)
CBG15263Protein CBG15263. (94 aa)
best-17Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (488 aa)
Cbr-tag-266Protein CBR-TAG-266. (184 aa)
trp-2Protein CBR-TRP-2; Belongs to the transient receptor (TC 1.A.4) family. (965 aa)
stg-2Protein CBR-STG-2. (373 aa)
CBG02060Protein CBG02060. (342 aa)
ucr-2.1Protein CBR-UCR-2.1. (410 aa)
unc-36Voltage-dependent calcium channel unc-36; May act as an auxiliary subunit of the unc-2 voltage-gated calcium channel which appears to trigger calcium-activated signaling pathways that control the serotonin response. Inhibiting serotonin sensitivity of the vulval muscles results in egg laying defects. May act in both neurons and muscle cells to enhance motor activity as it is required for coordinated movement. Has a role in neural depolarization- induced calcium influx and pharyngeal pumping. Involved in restricting the expression of the putative olfactory receptor str-2 to only one of [...] (1254 aa)
kvs-1Protein CBR-KVS-1; Belongs to the potassium channel family. (472 aa)
cng-2Protein CBG16807. (814 aa)
cca-1Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (1921 aa)
best-15Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (681 aa)
kvs-4Protein CBR-KVS-4; Belongs to the potassium channel family. (497 aa)
glr-1Protein CBR-GLR-1. (978 aa)
best-23Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (405 aa)
nuo-1NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (479 aa)
Cbr-tag-180Protein CBR-TAG-180. (1142 aa)
stg-1Protein CBR-STG-1. (843 aa)
abch-1Protein CBR-ABCH-1. (595 aa)
mps-1Protein CBR-MPS-1. (308 aa)
CBG02478Protein CBG02478. (186 aa)
nmr-1Protein CBR-NMR-1; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1064 aa)
best-22Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (506 aa)
best-13Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (413 aa)
ccb-2Protein CBR-CCB-2. (366 aa)
ctb-1Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (370 aa)
nd4lNADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (77 aa)
CBG03233Probable NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (160 aa)
orai-1Protein orai; Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, stim-1. Required for Ca(2+) and IP3-dependent contractile activity of sheath cells and the spermatheca. Affects brood size and somatic cell function (By similarity); Belongs to the Orai family. (300 aa)
eat-2Neuronal acetylcholine receptor subunit eat-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping. Has a role in the determination of life span possibly via calorific restriction which affects growth rate, although this is independent of metabolic activity (By similarity). (481 aa)
CBG29118Protein CBG29118. (160 aa)
amt-4.1Ammonium transporter. (582 aa)
CBG26024Protein CBG26024. (68 aa)
CBG28046Protein CBG28046. (156 aa)
CBG23138Protein CBG23138. (368 aa)
CBG22517Protein CBG22517. (661 aa)
atm-1Protein CBR-ATM-1; Belongs to the PI3/PI4-kinase family. (639 aa)
CBG22013Protein CBG22013. (1122 aa)
CBG25106Protein CBG25106. (639 aa)
nuo-3Protein CBR-NUO-3. (131 aa)
cua-1Protein CBR-CUA-1. (1271 aa)
ras-1Protein CBR-RAS-1. (211 aa)
CBG20772Protein CBG20772. (164 aa)
CBG20679Protein CBG20679. (199 aa)
glc-2Protein CBR-GLC-2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (454 aa)
nduf-9Protein CBG20301. (428 aa)
Cbr-unc-103.1Protein CBR-UNC-103.1. (140 aa)
CBG20020Protein CBG20020. (150 aa)
sol-2Protein CBG19743. (299 aa)
exc-4Protein CBR-EXC-4. (291 aa)
nduf-2.2Protein CBR-NDUF-2.2; Belongs to the complex I 49 kDa subunit family. (474 aa)
kvs-3Protein CBR-KVS-3; Belongs to the potassium channel family. (443 aa)
mod-1Protein CBR-MOD-1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (490 aa)
best-8Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (494 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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