(119 nodes) Serine-threonine/tyrosine-protein kinase, catalytic domain network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CBG00320	Tyrosine-protein kinase. (284 aa)
	CBG00279	Protein CBG00279. (218 aa)
	trk-1	Protein CBR-TRK-1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (825 aa)
	lin-2	Protein CBR-LIN-2; Belongs to the MAGUK family. (1009 aa)
	gcy-18	Guanylate cyclase. (1145 aa)
	lin-45	Raf homolog serine/threonine-protein kinase; Protein kinase that participates in the induction of vulva and has a role in fertility and viability. Acts downstream of the Ras protein let-60. Required for progression of developing oocytes through the pachytene stage. Positively regulates lifespan upstream of mek-2 and mpk-1. (811 aa)
	rol-3	Protein roller-3; Involved in larval development and locomotion. (2439 aa)
	CBG24788	Protein CBG24788. (1096 aa)
	CBG25959	Protein CBG25959. (141 aa)
	CBG25458	Guanylate cyclase. (1148 aa)
	daf-11	Guanylate cyclase. (1277 aa)
	rskd-1	Protein CBR-RSKD-1. (850 aa)
	CBG05239	Protein CBG05239. (876 aa)
	gcy-22	Guanylate cyclase. (1076 aa)
	CBG05605	Protein CBG05605. (717 aa)
	CBG06559	Guanylate cyclase. (1291 aa)
	odr-1	Protein CBR-ODR-1. (609 aa)
	CBG08016	Tyrosine-protein kinase. (466 aa)
	kin-5.1	Tyrosine-protein kinase. (529 aa)
	CBG08480	Tyrosine-protein kinase. (448 aa)
	mlk-1	Protein CBR-MLK-1. (1091 aa)
	CBG08594	Protein CBG08594. (389 aa)
	dlk-1	Mitogen-activated protein kinase kinase kinase dlk-1; Component of a MAP kinase pathway that functions presynaptically to regulate synaptic architecture and presynaptic differentiation. Phosphorylates and activates mkk-4 (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (857 aa)
	src-2	Tyrosine-protein kinase. (512 aa)
	kin-5.2	Tyrosine-protein kinase. (549 aa)
	CBG09666	Protein CBG09666. (1384 aa)
	Cbr-gcy-6	Guanylate cyclase. (1104 aa)
	CBG05171	Protein CBG05171. (994 aa)
	spe-8	Spermatocyte protein spe-8; Probable non-receptor tyrosine-protein kinase which plays a role in spermatid activation (spermiogenesis) in hermaphrodites. (479 aa)
	CBG04913	Protein CBG04913. (401 aa)
	CBG04912	Protein CBG04912. (283 aa)
	CBG04908	Protein CBG04908. (372 aa)
	CBG04907	Protein CBG04907. (385 aa)
	CBG04906	Protein CBG04906; Belongs to the protein kinase superfamily. Tyr protein kinase family. (458 aa)
	CBG04848	Protein CBG04848. (366 aa)
	gcy-14	Guanylate cyclase. (1125 aa)
	hir-1	Protein CBG09377. (1082 aa)
	CBG09305	Protein CBG09305. (167 aa)
	frk-1	Tyrosine-protein kinase. (389 aa)
	CBG12879	Tyrosine-protein kinase. (577 aa)
	CBG12830	Tyrosine-protein kinase. (643 aa)
	CBG12006	Tyrosine-protein kinase. (553 aa)
	CBG11187	Protein CBG11187. (719 aa)
	svh-2	Protein CBG10839; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1120 aa)
	CBG10819	Tyrosine-protein kinase. (399 aa)
	kin-32	Protein CBR-KIN-32; Belongs to the protein kinase superfamily. Tyr protein kinase family. (865 aa)
	CBG10328	Tyrosine-protein kinase. (417 aa)
	CBG09992	Tyrosine-protein kinase. (558 aa)
	CBG03859	Tyrosine-protein kinase. (432 aa)
	mom-4	Mitogen-activated protein kinase kinase kinase mom-4; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1 (By similarity). (545 aa)
	CBG03830	Protein CBG03830. (415 aa)
	CBG03803	Tyrosine-protein kinase. (473 aa)
	CBG04179	Tyrosine-protein kinase. (543 aa)
	csk-1	Tyrosine-protein kinase. (536 aa)
	gcy-17	Guanylate cyclase. (1095 aa)
	CBG03602	Protein CBG03602. (579 aa)
	CBG03551	Tyrosine-protein kinase. (564 aa)
	CBG02348	Tyrosine-protein kinase. (861 aa)
	gcy-12	Guanylate cyclase. (1690 aa)
	CBG02628	Tyrosine-protein kinase. (399 aa)
	CBG03127	Tyrosine-protein kinase. (481 aa)
	gcy-23	Guanylate cyclase. (1047 aa)
	daf-1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (665 aa)
	CBG01733	Protein CBG01733. (299 aa)
	gcy-5	Guanylate cyclase. (1242 aa)
	gcy-4	Receptor-type guanylate cyclase gcy-4; Guanylate cyclase involved in the production of the second messenger cGMP. Regulates chemotaxis responses toward salt ions in ASE sensory neurons (By similarity). (1135 aa)
	Cbr-gcy-1	Guanylate cyclase. (957 aa)
	CBG00895	Tyrosine-protein kinase. (423 aa)
	let-23	Receptor protein-tyrosine kinase. (1379 aa)
	src-1	Tyrosine-protein kinase. (544 aa)
	kin-21	Tyrosine-protein kinase. (562 aa)
	CBG20896	Protein CBG20896. (517 aa)
	gcy-29	Guanylate cyclase. (1072 aa)
	nipi-4	Protein CBG20555. (396 aa)
	hpo-11	Protein CBR-HPO-11. (582 aa)
	kin-14	Tyrosine-protein kinase. (406 aa)
	CBG20434	Protein CBG20434. (403 aa)
	CBG20403	Protein CBG20403. (165 aa)
	cam-1	Protein CBR-CAM-1. (916 aa)
	CBG19686	Protein CBG19686. (121 aa)
	gcy-21	Guanylate cyclase. (1193 aa)
	CBG19453	Protein CBG19453. (621 aa)
	gcy-13	Guanylate cyclase. (1066 aa)
	kin-9	Protein CBR-KIN-9. (618 aa)
	CBG04490	Protein CBG04490. (696 aa)
	abl-1	Tyrosine-protein kinase. (1211 aa)
	CBG19102	Protein CBG19102. (1014 aa)
	scd-2	Protein CBR-SCD-2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1476 aa)
	CBG18159	Tyrosine-protein kinase. (579 aa)
	CBG18214	Protein CBG18214; Belongs to the protein kinase superfamily. Tyr protein kinase family. (238 aa)
	gcy-8	Guanylate cyclase. (1188 aa)
	egl-15	Receptor protein-tyrosine kinase. (1192 aa)
	ver-3	Protein CBR-VER-3. (1313 aa)
	CBG17535	Receptor protein-tyrosine kinase. (1447 aa)
	CBG17534	Protein CBG17534. (573 aa)
	gcy-9	Guanylate cyclase. (1156 aa)
	zak-1	Protein CBR-ZAK-1. (769 aa)
	CBG16624	Protein CBG16624. (700 aa)
	CBG16480	Tyrosine-protein kinase. (487 aa)
	CBG16200	Protein CBG16200. (1021 aa)
	sid-3	Protein CBR-KIN-25; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1266 aa)
	gcy-11	Guanylate cyclase. (1097 aa)
	ksr-2	Protein CBR-KSR-2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (589 aa)
	Cbr-pat-4	Protein CBR-PAT-4. (278 aa)
	daf-2	Protein CBR-DAF-2. (1840 aa)
	CBG15247	Protein CBG15247. (846 aa)
	CBG14966	Tyrosine-protein kinase. (505 aa)
	CBG14937	Tyrosine-protein kinase. (642 aa)
	gcy-28	Guanylate cyclase. (1264 aa)
	ddr-1	Protein CBR-DDR-1. (821 aa)
	lin-18	Protein CBR-LIN-18. (599 aa)
	ddr-2	Protein CBR-DDR-2. (898 aa)
	ark-1	Protein CBR-ARK-1. (1032 aa)
	CBG13495	Protein CBG13495. (468 aa)
	kin-16	Protein CBR-KIN-16; Belongs to the protein kinase superfamily. Tyr protein kinase family. (501 aa)
	kin-15	Protein CBR-KIN-15; Belongs to the protein kinase superfamily. Tyr protein kinase family. (506 aa)
	vab-1	Protein CBR-VAB-1. (1118 aa)
	kin-24	Tyrosine-protein kinase. (523 aa)
	CBG00445	Protein CBG00445; Belongs to the protein kinase superfamily. Tyr protein kinase family. (440 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG00279	lin-2	A8WML6	A8WMC8	Protein CBG00279.	Protein CBR-LIN-2; Belongs to the MAGUK family.	0.428
CBG00320	CBG05239	A8WMP8	A8WZG4	Tyrosine-protein kinase.	Protein CBG05239.	0.508
CBG00320	CBG08594	A8WMP8	A8X717	Tyrosine-protein kinase.	Protein CBG08594.	0.477
CBG00320	kin-15	A8WMP8	A8XHW0	Tyrosine-protein kinase.	Protein CBR-KIN-15; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.467
CBG00320	kin-16	A8WMP8	A8XHW1	Tyrosine-protein kinase.	Protein CBR-KIN-16; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.523
CBG00320	kin-32	A8WMP8	A8XBU1	Tyrosine-protein kinase.	Protein CBR-KIN-32; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.417
CBG00320	lin-2	A8WMP8	A8WMC8	Tyrosine-protein kinase.	Protein CBR-LIN-2; Belongs to the MAGUK family.	0.428
CBG00445	CBG14937	A8WN39	A8XL17	Protein CBG00445; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Tyrosine-protein kinase.	0.491
CBG00445	kin-32	A8WN39	A8XBU1	Protein CBG00445; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Protein CBR-KIN-32; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.414
CBG00445	lin-2	A8WN39	A8WMC8	Protein CBG00445; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Protein CBR-LIN-2; Belongs to the MAGUK family.	0.428
CBG00445	src-1	A8WN39	A8Y1X2	Protein CBG00445; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Tyrosine-protein kinase.	0.461
CBG00445	src-2	A8WN39	A8X798	Protein CBG00445; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Tyrosine-protein kinase.	0.411
CBG00895	kin-32	A8WPD7	A8XBU1	Tyrosine-protein kinase.	Protein CBR-KIN-32; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.409
CBG00895	lin-2	A8WPD7	A8WMC8	Tyrosine-protein kinase.	Protein CBR-LIN-2; Belongs to the MAGUK family.	0.428
CBG01733	CBG14937	A8WQZ3	A8XL17	Protein CBG01733.	Tyrosine-protein kinase.	0.411
CBG01733	lin-2	A8WQZ3	A8WMC8	Protein CBG01733.	Protein CBR-LIN-2; Belongs to the MAGUK family.	0.428
CBG01733	src-1	A8WQZ3	A8Y1X2	Protein CBG01733.	Tyrosine-protein kinase.	0.411
CBG01733	src-2	A8WQZ3	A8X798	Protein CBG01733.	Tyrosine-protein kinase.	0.411
CBG02348	lin-2	A8WUJ1	A8WMC8	Tyrosine-protein kinase.	Protein CBR-LIN-2; Belongs to the MAGUK family.	0.428
CBG02628	CBG09992	A8WTW0	A8XA45	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.520