(40 nodes) Rossmann-like alpha/beta/alpha sandwich fold network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cars-1	Protein CBR-CARS-1. (584 aa)
	CBG03983	Protein CBG03983. (255 aa)
	pps-1	Protein CBR-PPS-1. (668 aa)
	CBG09825	Protein CBG09825. (1092 aa)
	vars-1	Protein CBR-VARS-1. (1077 aa)
	lars-2	Protein CBR-LARS-2; Belongs to the class-I aminoacyl-tRNA synthetase family. (1083 aa)
	qns-1	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (703 aa)
	rars-2	Protein CBR-RARS-2; Belongs to the class-I aminoacyl-tRNA synthetase family. (509 aa)
	gmps-1	Protein CBG03001. (808 aa)
	tut-1	Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. (372 aa)
	asns-1	Protein CBR-ASNS-1. (572 aa)
	CBG00301	Protein CBG00301. (331 aa)
	iars-1	Protein CBR-IARS-1; Belongs to the class-I aminoacyl-tRNA synthetase family. (1141 aa)
	CBG12063	Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. (249 aa)
	iars-2	Protein CBR-IARS-2. (947 aa)
	glp-4	Protein CBR-VARS-2; Belongs to the class-I aminoacyl-tRNA synthetase family. (1075 aa)
	tut-2	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with tut-1/ctu-1 that ligates sulfur from thiocarboxylated urm-1 onto the uridine of tRNAs at wobble position. (349 aa)
	ears-2	Protein CBR-EARS-2; Belongs to the class-I aminoacyl-tRNA synthetase family. (467 aa)
	qars-1	Protein CBR-QARS-1; Belongs to the class-I aminoacyl-tRNA synthetase family. (782 aa)
	asns-2	Protein CBR-ASNS-2. (567 aa)
	nmat-1	Nicotinamide-nucleotide adenylyltransferase. (216 aa)
	pcyt-1	Protein CBR-PCYT-1. (349 aa)
	pcyt-2.2	Protein CBG16841. (347 aa)
	CBG16955	Protein CBG16955. (204 aa)
	rars-1	Protein CBR-RARS-1; Belongs to the class-I aminoacyl-tRNA synthetase family. (710 aa)
	CBG18542	Protein CBG18542. (432 aa)
	nmat-2	Nicotinamide-nucleotide adenylyltransferase. (225 aa)
	yars-1	Protein CBG19783. (1232 aa)
	lars-1	Protein CBR-LARS-1; Belongs to the class-I aminoacyl-tRNA synthetase family. (1186 aa)
	wars-1	Protein CBR-WARS-1; Belongs to the class-I aminoacyl-tRNA synthetase family. (319 aa)
	prx-10	Protein CBR-WARS-2. (650 aa)
	ears-1	Protein CBR-EARS-1. (1129 aa)
	pcyt-2.1	Protein CBG22040. (355 aa)
	CBG22156	Protein CBG22156. (396 aa)
	yars-2	Tyrosine--tRNA ligase. (455 aa)
	flad-1	Molybdenum cofactor biosynthesis protein-like region; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme; In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. (523 aa)
	mttu-1	Protein CBG06062. (393 aa)
	mars-1	Protein CBR-MARS-1; Belongs to the class-I aminoacyl-tRNA synthetase family. (921 aa)
	CBG06229	Protein CBG06229. (477 aa)
	CBG05149	Protein CBG05149. (273 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG00301	CBG03983	A8WMN1	A8WVW9	Protein CBG00301.	Protein CBG03983.	0.999
CBG03983	CBG00301	A8WVW9	A8WMN1	Protein CBG03983.	Protein CBG00301.	0.999
CBG03983	flad-1	A8WVW9	Q626I0	Protein CBG03983.	Molybdenum cofactor biosynthesis protein-like region; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme; In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.	0.601
CBG05149	CBG16955	A8WZ58	A8XQ50	Protein CBG05149.	Protein CBG16955.	0.901
CBG05149	pcyt-1	A8WZ58	A8XPQ3	Protein CBG05149.	Protein CBR-PCYT-1.	0.988
CBG06229	asns-1	A8X0L2	A8WQK1	Protein CBG06229.	Protein CBR-ASNS-1.	0.444
CBG06229	asns-2	A8X0L2	A8XMA3	Protein CBG06229.	Protein CBR-ASNS-2.	0.444
CBG06229	ears-2	A8X0L2	A8XI55	Protein CBG06229.	Protein CBR-EARS-2; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.503
CBG06229	gmps-1	A8X0L2	A8WT10	Protein CBG06229.	Protein CBG03001.	0.408
CBG06229	mars-1	A8X0L2	A8X0V9	Protein CBG06229.	Protein CBR-MARS-1; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.525
CBG09825	cars-1	A8X9Q9	A8WWA0	Protein CBG09825.	Protein CBR-CARS-1.	0.524
CBG09825	gmps-1	A8X9Q9	A8WT10	Protein CBG09825.	Protein CBG03001.	0.465
CBG09825	mars-1	A8X9Q9	A8X0V9	Protein CBG09825.	Protein CBR-MARS-1; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.513
CBG09825	mttu-1	A8X9Q9	A8X0Z8	Protein CBG09825.	Protein CBG06062.	0.564
CBG09825	tut-2	A8X9Q9	A8X8I6	Protein CBG09825.	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with tut-1/ctu-1 that ligates sulfur from thiocarboxylated urm-1 onto the uridine of tRNAs at wobble position.	0.922
CBG16955	CBG05149	A8XQ50	A8WZ58	Protein CBG16955.	Protein CBG05149.	0.901
CBG16955	pcyt-1	A8XQ50	A8XPQ3	Protein CBG16955.	Protein CBR-PCYT-1.	0.956
CBG18542	CBG22156	A8XTJ2	A8Y1N8	Protein CBG18542.	Protein CBG22156.	0.901
CBG22156	CBG18542	A8Y1N8	A8XTJ2	Protein CBG22156.	Protein CBG18542.	0.901
asns-1	CBG06229	A8WQK1	A8X0L2	Protein CBR-ASNS-1.	Protein CBG06229.	0.444