(15 nodes) Low-density lipoprotein (LDL) receptor class A, conserved site network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CBG12050	Protein CBG12050. (4940 aa)
	CBG25156	Protein CBG25156. (183 aa)
	lrx-1	Protein CBR-LRX-1. (365 aa)
	CBG19478	Protein CBG19478. (729 aa)
	lrp-1	Protein CBR-LRP-1. (4829 aa)
	CBG11153	Protein CBG11153. (904 aa)
	CBG11065	Protein CBG11065. (823 aa)
	unc-52	Protein CBR-UNC-52. (2481 aa)
	hen-1	Protein CBR-HEN-1. (118 aa)
	CBG09359	Protein CBG09359. (538 aa)
	egg-1	LDL receptor repeat-containing protein egg-1; Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial (By similarity). Seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane (By similarity). Appears to recruit or maintain together [...] (636 aa)
	CBG07635	Protein CBG07635. (339 aa)
	clec-78	Protein CBR-CLEC-78. (2226 aa)
	rme-2	Protein CBR-RME-2. (929 aa)
	svh-1	Protein CBR-TRY-2; Belongs to the peptidase S1 family. (921 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG07635	CBG11065	A8X4E4	A8XCB7	Protein CBG07635.	Protein CBG11065.	0.436
CBG07635	unc-52	A8X4E4	A8XCB6	Protein CBG07635.	Protein CBR-UNC-52.	0.436
CBG11065	CBG07635	A8XCB7	A8X4E4	Protein CBG11065.	Protein CBG07635.	0.436
CBG11065	CBG11153	A8XCB7	A8XCK6	Protein CBG11065.	Protein CBG11153.	0.631
CBG11065	CBG12050	A8XCB7	A8XEF6	Protein CBG11065.	Protein CBG12050.	0.631
CBG11065	CBG19478	A8XCB7	A8XVN1	Protein CBG11065.	Protein CBG19478.	0.444
CBG11065	CBG25156	A8XCB7	H8WH81	Protein CBG11065.	Protein CBG25156.	0.631
CBG11065	egg-1	A8XCB7	A8X765	Protein CBG11065.	LDL receptor repeat-containing protein egg-1; Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial (By similarity). Seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane (By similarity). Appears to recruit or maintain together [...]	0.610
CBG11065	lrp-1	A8XCB7	A8XE81	Protein CBG11065.	Protein CBR-LRP-1.	0.631
CBG11065	rme-2	A8XCB7	A8WWR1	Protein CBG11065.	Protein CBR-RME-2.	0.436
CBG11153	CBG11065	A8XCK6	A8XCB7	Protein CBG11153.	Protein CBG11065.	0.631
CBG11153	unc-52	A8XCK6	A8XCB6	Protein CBG11153.	Protein CBR-UNC-52.	0.631
CBG12050	CBG11065	A8XEF6	A8XCB7	Protein CBG12050.	Protein CBG11065.	0.631
CBG12050	unc-52	A8XEF6	A8XCB6	Protein CBG12050.	Protein CBR-UNC-52.	0.631
CBG19478	CBG11065	A8XVN1	A8XCB7	Protein CBG19478.	Protein CBG11065.	0.444
CBG19478	unc-52	A8XVN1	A8XCB6	Protein CBG19478.	Protein CBR-UNC-52.	0.444
CBG25156	CBG11065	H8WH81	A8XCB7	Protein CBG25156.	Protein CBG11065.	0.631
CBG25156	unc-52	H8WH81	A8XCB6	Protein CBG25156.	Protein CBR-UNC-52.	0.631
egg-1	CBG11065	A8X765	A8XCB7	LDL receptor repeat-containing protein egg-1; Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial (By similarity). Seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane (By similarity). Appears to recruit or maintain together [...]	Protein CBG11065.	0.610
egg-1	rme-2	A8X765	A8WWR1	LDL receptor repeat-containing protein egg-1; Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial (By similarity). Seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane (By similarity). Appears to recruit or maintain together [...]	Protein CBR-RME-2.	0.526