(45 nodes) Toll Like Receptor 3 (TLR3) Cascade network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ubl-1	Ubiquitin-like protein 1-40S ribosomal protein S27a; In the N-terminal section; belongs to the ubiquitin family. (163 aa)
	CBG00447	Protein CBG00447. (388 aa)
	usp-14	Ubiquitin carboxyl-terminal hydrolase. (489 aa)
	mkk-4	Protein CBR-MKK-4; Belongs to the protein kinase superfamily. (363 aa)
	CBG03271	Protein CBG03271. (197 aa)
	CBG03194	Protein CBG03194. (960 aa)
	CBG02328	Protein CBG02328. (438 aa)
	mpk-2	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (573 aa)
	rege-1	Protein CBG03935. (660 aa)
	mom-4	Mitogen-activated protein kinase kinase kinase mom-4; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1 (By similarity). (545 aa)
	paa-1	Protein CBR-PAA-1. (606 aa)
	let-92	Serine/threonine-protein phosphatase. (318 aa)
	jnk-1	Mitogen-activated protein kinase. (464 aa)
	tap-1	Protein CBR-TAP-1. (389 aa)
	rskn-2	Ribosomal protein S6 kinase. (772 aa)
	CBG09113	Protein CBG09113. (189 aa)
	ubq-1	Protein CBR-UBQ-1. (770 aa)
	CBG11917	Protein CBG11917. (165 aa)
	CBG12102	Protein CBG12102. (186 aa)
	rskn-1	Ribosomal protein S6 kinase. (803 aa)
	crh-1	Protein CBR-CRH-1. (407 aa)
	ubc-13	Protein CBR-UBC-13; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	kgb-1	Mitogen-activated protein kinase. (382 aa)
	CBG13650	Protein CBG13650. (303 aa)
	mak-2	Protein CBR-MAK-2; Belongs to the protein kinase superfamily. (366 aa)
	lin-1	Protein CBR-ELK-2. (411 aa)
	CBG14588	Protein CBG14588. (689 aa)
	jkk-1	Protein CBR-JKK-1. (435 aa)
	CBG14677	Protein CBG14677. (358 aa)
	ubq-2	Protein CBR-UBQ-2. (128 aa)
	zak-1	Protein CBR-ZAK-1. (769 aa)
	mek-1	Protein CBR-MEK-1. (463 aa)
	sek-1	Protein CBR-SEK-1; Belongs to the protein kinase superfamily. (352 aa)
	CBG17796	Protein CBG17796. (53 aa)
	kxd-1	Protein CBG19105. (130 aa)
	mltn-5	Protein CBG20749. (716 aa)
	mltn-4	Protein CBG20751. (696 aa)
	mltn-3	Protein CBG20752. (797 aa)
	mapk-15	Mitogen-activated protein kinase. (458 aa)
	mpk-1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
	CBG21256	Protein CBG21256. (378 aa)
	ppfr-1	Protein CBR-PPFR-1. (1472 aa)
	CBG22188	Protein CBG22188. (248 aa)
	CBG25344	Protein CBG25344. (78 aa)
	jun-1	Protein CBG03270, isoform a. (323 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG00447	CBG02328	A8WN41	A8WUK8	Protein CBG00447.	Protein CBG02328.	0.422
CBG00447	CBG03271	A8WN41	A8WSE7	Protein CBG00447.	Protein CBG03271.	0.811
CBG00447	CBG14588	A8WN41	A8XK90	Protein CBG00447.	Protein CBG14588.	0.825
CBG00447	CBG14677	A8WN41	A8XKF5	Protein CBG00447.	Protein CBG14677.	0.579
CBG00447	jkk-1	A8WN41	A8XKF4	Protein CBG00447.	Protein CBR-JKK-1.	0.797
CBG00447	jun-1	A8WN41	H8WH96	Protein CBG00447.	Protein CBG03270, isoform a.	0.811
CBG00447	mak-2	A8WN41	A8XIW8	Protein CBG00447.	Protein CBR-MAK-2; Belongs to the protein kinase superfamily.	0.600
CBG00447	mek-1	A8WN41	A8XPM7	Protein CBG00447.	Protein CBR-MEK-1.	0.790
CBG00447	mkk-4	A8WN41	A8WRM6	Protein CBG00447.	Protein CBR-MKK-4; Belongs to the protein kinase superfamily.	0.822
CBG00447	mom-4	A8WN41	A8WWX1	Protein CBG00447.	Mitogen-activated protein kinase kinase kinase mom-4; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1 (By similarity).	0.679
CBG00447	mpk-2	A8WN41	A8WUK9	Protein CBG00447.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.414
CBG00447	sek-1	A8WN41	A8XPU4	Protein CBG00447.	Protein CBR-SEK-1; Belongs to the protein kinase superfamily.	0.562
CBG00447	zak-1	A8WN41	A8XPG3	Protein CBG00447.	Protein CBR-ZAK-1.	0.481
CBG02328	CBG00447	A8WUK8	A8WN41	Protein CBG02328.	Protein CBG00447.	0.422
CBG02328	CBG03271	A8WUK8	A8WSE7	Protein CBG02328.	Protein CBG03271.	0.538
CBG02328	CBG09113	A8WUK8	A8X7R9	Protein CBG02328.	Protein CBG09113.	0.530
CBG02328	CBG14588	A8WUK8	A8XK90	Protein CBG02328.	Protein CBG14588.	0.427
CBG02328	CBG14677	A8WUK8	A8XKF5	Protein CBG02328.	Protein CBG14677.	0.801
CBG02328	CBG25344	A8WUK8	B6IIK8	Protein CBG02328.	Protein CBG25344.	0.622
CBG02328	jun-1	A8WUK8	H8WH96	Protein CBG02328.	Protein CBG03270, isoform a.	0.538