STRINGSTRING
arx-4 arx-4 itsn-1 itsn-1 CBG01565 CBG01565 wsp-1 wsp-1 Cbr-max-2 Cbr-max-2 max-2 max-2 nmr-1 nmr-1 arx-7 arx-7 efn-2 efn-2 sdn-1 sdn-1 unc-60 unc-60 efn-3 efn-3 sel-12 sel-12 vab-2 vab-2 CBG10797 CBG10797 unc-73 unc-73 CBG12078 CBG12078 hop-1 hop-1 pen-2 pen-2 vab-1 vab-1 pak-1 pak-1 CBG14863 CBG14863 arx-5 arx-5 viro-2 viro-2 CBG17392 CBG17392 arx-6 arx-6 arx-3 arx-3 CBG19473 CBG19473 aph-2 aph-2 gap-3 gap-3 aph-1 aph-1 CBG25604 CBG25604 spe-4 spe-4 arx-2 arx-2 arx-1 arx-1 efn-4 efn-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
arx-4Protein CBR-ARX-4. (539 aa)
itsn-1Protein CBR-ITSN-1. (1099 aa)
CBG01565Protein CBG01565. (188 aa)
wsp-1Protein CBR-WSP-1. (785 aa)
Cbr-max-2Protein CBR-MAX-2; Belongs to the protein kinase superfamily. (422 aa)
max-2Protein CBG02801. (317 aa)
nmr-1Protein CBR-NMR-1; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1064 aa)
arx-7Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (152 aa)
efn-2Protein CBR-EFN-2; Belongs to the ephrin family. (219 aa)
sdn-1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (298 aa)
unc-60Protein CBR-UNC-60; Belongs to the actin-binding proteins ADF family. (293 aa)
efn-3Protein CBR-EFN-3; Belongs to the ephrin family. (200 aa)
sel-12Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (450 aa)
vab-2Protein CBR-VAB-2; Belongs to the ephrin family. (242 aa)
CBG10797Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (215 aa)
unc-73Protein CBR-UNC-73. (1618 aa)
CBG12078Protein CBG12078. (812 aa)
hop-1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (358 aa)
pen-2Protein CBR-PEN-2. (101 aa)
vab-1Protein CBR-VAB-1. (1118 aa)
pak-1Non-specific serine/threonine protein kinase. (626 aa)
CBG14863Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa)
arx-5Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa)
viro-2Protein CBG16600. (552 aa)
CBG17392Protein CBG17392. (1745 aa)
arx-6Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (169 aa)
arx-3Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (382 aa)
CBG19473Protein CBG19473. (96 aa)
aph-2Protein CBR-APH-2. (721 aa)
gap-3Protein CBG22075. (960 aa)
aph-1Protein CBR-APH-1. (330 aa)
CBG25604Protein CBG25604. (262 aa)
spe-4Protein CBR-SPE-4. (483 aa)
arx-2Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (393 aa)
arx-1Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (426 aa)
efn-4Ephrin-4; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, involved in ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting together with mab-20 and allows the formation of distinct sensory rays. Probably acts as a ligand for lad-2 to regulate axon guidance of several neurons including SDQL, SDQR, SMD and PLN neurons during neurogenesis; Belongs to the ephrin family. (354 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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