(22 nodes) Regulation of TP53 Expression and Degradation network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CBG17796	Protein CBG17796. (53 aa)
	kxd-1	Protein CBG19105. (130 aa)
	sinh-1	Protein CBR-SINH-1. (638 aa)
	CBG00206	Protein CBG00206; Belongs to the protein kinase superfamily. (350 aa)
	math-33	Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins. (1129 aa)
	ubl-1	Ubiquitin-like protein 1-40S ribosomal protein S27a; In the N-terminal section; belongs to the ubiquitin family. (163 aa)
	atm-1	Protein CBR-ATM-1; Belongs to the PI3/PI4-kinase family. (639 aa)
	CBG22013	Protein CBG22013. (1122 aa)
	pdk-1	Protein CBR-PDK-1. (644 aa)
	Cbr-gpn-1	Protein CBR-GPN-1; Belongs to the glypican family. (1442 aa)
	cya-1	Protein CBG06936; Belongs to the cyclin family. (467 aa)
	let-92	Serine/threonine-protein phosphatase. (318 aa)
	paa-1	Protein CBR-PAA-1. (606 aa)
	mlst-8	Protein CBG03961. (343 aa)
	blmp-1	Protein CBR-BLMP-1. (799 aa)
	ubq-1	Protein CBR-UBQ-1. (770 aa)
	akt-1	Non-specific serine/threonine protein kinase. (605 aa)
	CBG12102	Protein CBG12102. (186 aa)
	let-363	Serine/threonine-protein kinase TOR. (1721 aa)
	CBG15618	Protein CBG15618. (460 aa)
	CBG15660	Protein CBG15660; Belongs to the protein kinase superfamily. (299 aa)
	ubq-2	Protein CBR-UBQ-2. (128 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG00206	CBG15618	A8WMH0	A8XME2	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBG15618.	0.736
CBG00206	CBG15660	A8WMH0	A8XMH2	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBG15660; Belongs to the protein kinase superfamily.	0.778
CBG00206	let-363	A8WMH0	A8XFR2	Protein CBG00206; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase TOR.	0.764
CBG00206	let-92	A8WMH0	A8X0Q9	Protein CBG00206; Belongs to the protein kinase superfamily.	Serine/threonine-protein phosphatase.	0.710
CBG00206	mlst-8	A8WMH0	A8WVV0	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBG03961.	0.629
CBG00206	paa-1	A8WMH0	A8WZC4	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBR-PAA-1.	0.588
CBG00206	pdk-1	A8WMH0	A8X5P7	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBR-PDK-1.	0.769
CBG00206	sinh-1	A8WMH0	A8XYY8	Protein CBG00206; Belongs to the protein kinase superfamily.	Protein CBR-SINH-1.	0.727
CBG12102	CBG17796	A8XER6	A8XRT8	Protein CBG12102.	Protein CBG17796.	0.952
CBG12102	cya-1	A8XER6	A8X3E4	Protein CBG12102.	Protein CBG06936; Belongs to the cyclin family.	0.663
CBG12102	let-92	A8XER6	A8X0Q9	Protein CBG12102.	Serine/threonine-protein phosphatase.	0.525
CBG12102	math-33	A8XER6	Q60MK8	Protein CBG12102.	Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins.	0.870
CBG12102	paa-1	A8XER6	A8WZC4	Protein CBG12102.	Protein CBR-PAA-1.	0.452
CBG12102	ubl-1	A8XER6	P37164	Protein CBG12102.	Ubiquitin-like protein 1-40S ribosomal protein S27a; In the N-terminal section; belongs to the ubiquitin family.	0.998
CBG12102	ubq-1	A8XER6	A8X7Y8	Protein CBG12102.	Protein CBR-UBQ-1.	0.999
CBG12102	ubq-2	A8XER6	A8XMR9	Protein CBG12102.	Protein CBR-UBQ-2.	0.908
CBG15618	CBG00206	A8XME2	A8WMH0	Protein CBG15618.	Protein CBG00206; Belongs to the protein kinase superfamily.	0.736
CBG15618	akt-1	A8XME2	A8X8T0	Protein CBG15618.	Non-specific serine/threonine protein kinase.	0.844
CBG15618	let-363	A8XME2	A8XFR2	Protein CBG15618.	Serine/threonine-protein kinase TOR.	0.446
CBG15660	CBG00206	A8XMH2	A8WMH0	Protein CBG15660; Belongs to the protein kinase superfamily.	Protein CBG00206; Belongs to the protein kinase superfamily.	0.778