(64 nodes) p53-Independent DNA Damage Response network (Caenorhabditis briggsae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CBG00525	Protein CBG00525; Belongs to the protein kinase superfamily. (296 aa)
	pas-5	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (258 aa)
	rpn-9	Protein CBR-RPN-9. (382 aa)
	rpn-12	Protein CBR-RPN-12. (250 aa)
	pbs-3	Proteasome subunit beta. (204 aa)
	CBG03866	Protein CBG03866. (1794 aa)
	rpn-5	Protein CBR-RPN-5. (491 aa)
	pas-1	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (246 aa)
	CBG04772	Protein CBG04772; Belongs to the AAA ATPase family. (426 aa)
	rpn-1	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (992 aa)
	rpn-6.2	Probable 26S proteasome regulatory subunit rpn-6.2; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.2 is required for proteasome assembly (By similarity); Belongs to the proteasome subunit S9 family. (411 aa)
	CBG10242	Protein CBG10242. (358 aa)
	CBG07148	Protein CBG07148. (700 aa)
	CBG07147	Protein CBG07147. (318 aa)
	CBG07138	Protein CBG07138. (178 aa)
	rpt-4	Protein CBR-RPT-4; Belongs to the AAA ATPase family. (398 aa)
	pbs-2	Proteasome subunit beta. (277 aa)
	CBG08524	Protein CBG08524. (1917 aa)
	CBG08884	Protein CBG08884. (289 aa)
	chk-1	Serine/threonine-protein kinase chk-1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Required for checkpoint mediated cell cycle arrest in response to DNA damage in germline cells. Essential for embryogenesis (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. (493 aa)
	ubl-1	Ubiquitin-like protein 1-40S ribosomal protein S27a; In the N-terminal section; belongs to the ubiquitin family. (163 aa)
	CBG24469	Protein CBG24469. (272 aa)
	CBG20339	Protein CBG20339; Belongs to the AAA ATPase family. (415 aa)
	rpt-1	Protein CBR-RPT-1; Belongs to the AAA ATPase family. (435 aa)
	rpn-7	Protein CBR-RPN-7. (409 aa)
	chk-2	Protein CBR-CHK-2. (289 aa)
	pbs-5	Protein CBR-PBS-5. (284 aa)
	CBG19367	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (239 aa)
	kxd-1	Protein CBG19105. (130 aa)
	rpn-3	Protein CBR-RPN-3. (506 aa)
	CBG18037	Protein CBG18037. (490 aa)
	CBG00041	Protein CBG00041; Belongs to the protein kinase superfamily. (296 aa)
	CBG24546	Protein CBG24546. (299 aa)
	rpn-2	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (970 aa)
	rpn-11	Protein CBR-RPN-11. (312 aa)
	CBG23920	Protein CBG23920; Belongs to the AAA ATPase family. (268 aa)
	CBG10241	Protein CBG10241. (289 aa)
	CBG10240	Protein CBG10240; Belongs to the protein kinase superfamily. (295 aa)
	CBG10664	Protein CBG10664. (295 aa)
	CBG10679	Protein CBG10679. (409 aa)
	pas-3	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (250 aa)
	psmd-9	Protein CBG11181. (196 aa)
	rpt-6	Protein CBR-RPT-6; Belongs to the AAA ATPase family. (417 aa)
	pbs-4	Proteasome subunit beta. (196 aa)
	rpn-8	Protein CBR-RPN-8. (382 aa)
	CBG12102	Protein CBG12102. (186 aa)
	pbs-7	Proteasome subunit beta; Belongs to the peptidase T1B family. (251 aa)
	pas-4	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (253 aa)
	rpn-10	Protein CBR-RPN-10. (347 aa)
	rpt-5	Protein CBR-RPT-5; Belongs to the AAA ATPase family. (430 aa)
	CBG13260	Protein CBG13260. (251 aa)
	pas-7	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (250 aa)
	pbs-1	Proteasome subunit beta. (239 aa)
	ubq-2	Protein CBR-UBQ-2. (128 aa)
	CBG15809	Protein CBG15809. (626 aa)
	CBG16303	Protein CBG16303. (552 aa)
	rpn-6.1	Protein CBR-RPN-6.1. (404 aa)
	CBG17796	Protein CBG17796. (53 aa)
	rpt-2	Protein CBR-RPT-2; Belongs to the AAA ATPase family. (443 aa)
	pas-6	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (255 aa)
	pas-2	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (231 aa)
	ubq-1	Protein CBR-UBQ-1. (770 aa)
	rpt-3	Protein CBR-RPT-3; Belongs to the AAA ATPase family. (417 aa)
	CBG08885	Protein CBG08885. (257 aa)

Your Current Organism:

Caenorhabditis briggsae

NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG00041	CBG24469	A8WM70	H8WH98	Protein CBG00041; Belongs to the protein kinase superfamily.	Protein CBG24469.	0.458
CBG00041	chk-2	A8WM70	A8XXZ2	Protein CBG00041; Belongs to the protein kinase superfamily.	Protein CBR-CHK-2.	0.458
CBG00525	CBG24469	A8WNP5	H8WH98	Protein CBG00525; Belongs to the protein kinase superfamily.	Protein CBG24469.	0.458
CBG00525	chk-2	A8WNP5	A8XXZ2	Protein CBG00525; Belongs to the protein kinase superfamily.	Protein CBR-CHK-2.	0.458
CBG03866	CBG04772	A8WWY3	A8WYF6	Protein CBG03866.	Protein CBG04772; Belongs to the AAA ATPase family.	0.573
CBG03866	CBG08524	A8WWY3	A8X773	Protein CBG03866.	Protein CBG08524.	0.900
CBG03866	CBG13260	A8WWY3	A8XHF2	Protein CBG03866.	Protein CBG13260.	0.416
CBG03866	CBG19367	A8WWY3	A8XVG4	Protein CBG03866.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.802
CBG03866	CBG20339	A8WWY3	G2J711	Protein CBG03866.	Protein CBG20339; Belongs to the AAA ATPase family.	0.541
CBG03866	CBG23920	A8WWY3	A8WJL1	Protein CBG03866.	Protein CBG23920; Belongs to the AAA ATPase family.	0.541
CBG03866	pas-1	A8WWY3	A8WY28	Protein CBG03866.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.802
CBG03866	pas-2	A8WWY3	A8X8G7	Protein CBG03866.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.926
CBG03866	pas-3	A8WWY3	A8XBV0	Protein CBG03866.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.909
CBG03866	pas-4	A8WWY3	A8XFM4	Protein CBG03866.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.920
CBG03866	pas-5	A8WWY3	A8WS54	Protein CBG03866.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.909
CBG03866	pas-6	A8WWY3	A8X995	Protein CBG03866.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.909
CBG03866	pas-7	A8WWY3	A8XHU7	Protein CBG03866.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.932
CBG03866	pbs-1	A8WWY3	A8XI90	Protein CBG03866.	Proteasome subunit beta.	0.938
CBG03866	pbs-2	A8WWY3	A8X5E7	Protein CBG03866.	Proteasome subunit beta.	0.914
CBG03866	pbs-3	A8WWY3	A8WUP0	Protein CBG03866.	Proteasome subunit beta.	0.905