STRINGSTRING
icp-1 icp-1 npp-2 npp-2 CBG03913 CBG03913 npp-18 npp-18 mat-2 mat-2 ebp-2 ebp-2 ska-1 ska-1 CBG02222 CBG02222 dli-1 dli-1 zyg-9 zyg-9 emb-27 emb-27 nud-1 nud-1 npp-6 npp-6 nud-2 nud-2 CBG23584 CBG23584 cls-3 cls-3 CBG09173 CBG09173 cls-2 cls-2 zwl-1 zwl-1 CBG22319 CBG22319 CBG25886 CBG25886 CBG25885 CBG25885 pptr-2 pptr-2 ndc-80 ndc-80 bir-1 bir-1 CBG23414 CBG23414 apc-2 apc-2 pptr-1 pptr-1 CBG21913 CBG21913 CBG21459 CBG21459 lis-1 lis-1 CBG20697 CBG20697 bub-3 bub-3 xpo-1 xpo-1 npp-4 npp-4 dlc-1 dlc-1 mdf-1 mdf-1 apc-11 apc-11 mel-28 mel-28 CBG18333 CBG18333 klp-7 klp-7 czw-1 czw-1 mksr-2 mksr-2 rod-1 rod-1 CBG15203 CBG15203 npp-7 npp-7 klp-13 klp-13 mltn-13 mltn-13 mdf-2 mdf-2 npp-20 npp-20 dlc-3 dlc-3 CBG13581 CBG13581 such-1 such-1 san-1 san-1 mat-3 mat-3 CBG12411 CBG12411 npp-15 npp-15 ran-2 ran-2 CBG12075 CBG12075 bir-2 bir-2 mat-1 mat-1 clip-1 clip-1 bub-1 bub-1 apc-10 apc-10 npp-10 npp-10 him-10 him-10 gfi-3 gfi-3 let-92 let-92 ebp-1 ebp-1 dlc-5 dlc-5 dyci-1 dyci-1 paa-1 paa-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
icp-1Protein CBR-ICP-1. (516 aa)
npp-2Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (614 aa)
CBG03913Protein CBG03913. (215 aa)
npp-18Nucleoporin SEH1; Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus; Belongs to the WD repeat SEC13 family. (366 aa)
mat-2Protein CBR-MAT-2. (1853 aa)
ebp-2Protein CBR-EBP-2. (306 aa)
ska-1Spindle and kinetochore-associated protein 1 homolog; Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtu [...] (239 aa)
CBG02222Protein CBG02222. (436 aa)
dli-1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (441 aa)
zyg-9Protein CBR-ZYG-9. (1427 aa)
emb-27Protein CBR-EMB-27. (669 aa)
nud-1Protein CBR-NUD-1. (311 aa)
npp-6Protein CBR-NPP-6. (1549 aa)
nud-2Protein CBR-NUD-2. (281 aa)
CBG23584Protein CBG23584. (252 aa)
cls-3Protein CLASP-3; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules; Belongs to the CLASP family. (970 aa)
CBG09173Protein CLASP-1; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules; Belongs to the CLASP family. (1333 aa)
cls-2Protein CLASP-2; Probable microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the formation of mitotic and meiotic spindles. Specifically promotes the polymerization of kinetochore-bound microtubules. Also required for cytoplasmic streaming (By similarity). (791 aa)
zwl-1Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores and spindle pole separation. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome segregation, the complex also inhibits the attachment of [...] (639 aa)
CBG22319Protein CBG22319. (306 aa)
CBG25886Protein CBG25886. (111 aa)
CBG25885Protein CBG25885. (307 aa)
pptr-2Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (556 aa)
ndc-80Protein CBR-NDC-80. (599 aa)
bir-1Protein CBR-BIR-1. (158 aa)
CBG23414Protein CBG23414. (1631 aa)
apc-2Protein CBR-APC-2; Belongs to the cullin family. (700 aa)
pptr-1Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (531 aa)
CBG21913Protein CBG21913. (618 aa)
CBG21459Protein CBG21459. (655 aa)
lis-1Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. (390 aa)
CBG20697Protein CBG20697. (173 aa)
bub-3Protein CBR-BUB-3. (342 aa)
xpo-1Protein CBR-XPO-1. (1075 aa)
npp-4Protein CBR-NPP-4. (515 aa)
dlc-1Dynein light chain. (89 aa)
mdf-1Protein CBR-MDF-1. (681 aa)
apc-11Protein CBR-APC-11. (134 aa)
mel-28Protein CBR-MEL-28. (1559 aa)
CBG18333Protein CBG18333. (497 aa)
klp-7Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (743 aa)
czw-1Protein CBR-CZW-1. (778 aa)
mksr-2Protein CBR-MKSR-2. (175 aa)
rod-1Protein CBR-ROD-1. (2213 aa)
CBG15203Protein CBG15203. (648 aa)
npp-7Protein CBR-NPP-7. (1226 aa)
klp-13Protein CBR-KLP-13; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (602 aa)
mltn-13Protein CBR-MLTN-13. (752 aa)
mdf-2Protein CBR-MDF-2. (203 aa)
npp-20Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat; Belongs to the WD repeat SEC13 family. (306 aa)
dlc-3Dynein light chain. (136 aa)
CBG13581Protein CBG13581. (651 aa)
such-1Protein CBR-SUCH-1. (769 aa)
san-1Protein CBR-SAN-1. (390 aa)
mat-3Protein CBR-MAT-3. (667 aa)
CBG12411Protein CBG12411. (518 aa)
npp-15Protein CBR-NPP-15. (1146 aa)
ran-2Protein CBR-RAN-2. (975 aa)
CBG12075Protein CBG12075. (611 aa)
bir-2Protein CBR-BIR-2. (306 aa)
mat-1Protein CBR-MAT-1. (746 aa)
clip-1Protein CBG10142. (961 aa)
bub-1Protein CBR-BUB-1. (971 aa)
apc-10Protein CBR-APC-10. (144 aa)
npp-10Protein CBR-NPP-10. (1684 aa)
him-10Protein CBR-HIM-10. (637 aa)
gfi-3Protein CBR-GFI-3. (794 aa)
let-92Serine/threonine-protein phosphatase. (318 aa)
ebp-1Protein CBR-EBP-1. (303 aa)
dlc-5Protein CBR-DLC-5. (186 aa)
dyci-1Protein CBR-DYCI-1. (663 aa)
paa-1Protein CBR-PAA-1. (606 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.