STRINGSTRING
CBG23584 CBG23584 nud-2 nud-2 npp-6 npp-6 CBG23770 CBG23770 CBG23920 CBG23920 rpn-11 rpn-11 rpn-2 rpn-2 nud-1 nud-1 CBG24546 CBG24546 rfc-4 rfc-4 CBG00041 CBG00041 emb-27 emb-27 zyg-9 zyg-9 CBG00525 CBG00525 CBG01828 CBG01828 rfc-3 rfc-3 dli-1 dli-1 pas-5 pas-5 rmh-1 rmh-1 CBG02222 CBG02222 mus-101 mus-101 ska-1 ska-1 dna-2 dna-2 ebp-2 ebp-2 orc-2 orc-2 mat-2 mat-2 rpn-9 rpn-9 rpn-12 rpn-12 hpr-17 hpr-17 wrn-1 wrn-1 pbs-3 pbs-3 CBG03383 CBG03383 npp-18 npp-18 brc-1 brc-1 mcm-4 mcm-4 CBG03913 CBG03913 cdc-7 cdc-7 npp-2 npp-2 hsr-9 hsr-9 CBG03866 CBG03866 icp-1 icp-1 rpn-5 rpn-5 pas-1 pas-1 CBG04772 CBG04772 paa-1 paa-1 dyci-1 dyci-1 dlc-5 dlc-5 cyb-3 cyb-3 ebp-1 ebp-1 let-92 let-92 par-5 par-5 rpn-1 rpn-1 rpn-6.2 rpn-6.2 CBG06911 CBG06911 cya-1 cya-1 CBG07148 CBG07148 CBG07147 CBG07147 CBG07138 CBG07138 rpt-4 rpt-4 gfi-3 gfi-3 pbs-2 pbs-2 CBG08524 CBG08524 CBG08884 CBG08884 CBG08885 CBG08885 rpt-3 rpt-3 him-10 him-10 ubq-1 ubq-1 npp-10 npp-10 evl-18 evl-18 pas-2 pas-2 mre-11 mre-11 apc-10 apc-10 pas-6 pas-6 rpt-2 rpt-2 bub-1 bub-1 clip-1 clip-1 CBG10242 CBG10242 CBG10241 CBG10241 CBG10240 CBG10240 CBG10664 CBG10664 CBG10679 CBG10679 pas-3 pas-3 CBG10818 CBG10818 mat-1 mat-1 psmd-9 psmd-9 bir-2 bir-2 mcm-3 mcm-3 rpt-6 rpt-6 hus-1 hus-1 pbs-4 pbs-4 CBG12075 CBG12075 rpn-8 rpn-8 CBG12102 CBG12102 cdc-6 cdc-6 ran-2 ran-2 npp-15 npp-15 mcm-5 mcm-5 CBG12411 CBG12411 pbs-7 pbs-7 pas-4 pas-4 rpn-10 rpn-10 rpt-5 rpt-5 mat-3 mat-3 san-1 san-1 cki-1 cki-1 mcm-10 mcm-10 mrt-2 mrt-2 CBG13260 CBG13260 such-1 such-1 top-3 top-3 pas-7 pas-7 CBG13581 CBG13581 pbs-1 pbs-1 dlc-3 dlc-3 npp-20 npp-20 mdf-2 mdf-2 mltn-13 mltn-13 klp-13 klp-13 CBG14893 CBG14893 npp-7 npp-7 CBG15275 CBG15275 CBG15203 CBG15203 ubq-2 ubq-2 CBG15809 CBG15809 CBG16303 CBG16303 rpn-6.1 rpn-6.1 Cbr-rfc-4.1 Cbr-rfc-4.1 rod-1 rod-1 mksr-2 mksr-2 clsp-1 clsp-1 CBG17207 CBG17207 ftt-2 ftt-2 czw-1 czw-1 cyb-1 cyb-1 orc-5 orc-5 CBG17796 CBG17796 CBG17880 CBG17880 com-1 com-1 klp-7 klp-7 CBG18333 CBG18333 orc-1 orc-1 orc-4 orc-4 hpr-9 hpr-9 mel-28 mel-28 apc-11 apc-11 CBG18037 CBG18037 rpn-3 rpn-3 mcm-2 mcm-2 kxd-1 kxd-1 glo-4 glo-4 mdf-1 mdf-1 CBG19304 CBG19304 atl-1 atl-1 CBG19367 CBG19367 rmh-2 rmh-2 dlc-1 dlc-1 npp-4 npp-4 pbs-5 pbs-5 chk-2 chk-2 xpo-1 xpo-1 bub-3 bub-3 CBG20697 CBG20697 lis-1 lis-1 exo-1 exo-1 CBG21459 CBG21459 rpn-7 rpn-7 CBG21690 CBG21690 pezo-1 pezo-1 him-6 him-6 CBG21674 CBG21674 mcm-7 mcm-7 CBG21913 CBG21913 wee-1.1 wee-1.1 CBG21906 CBG21906 CBG22011 CBG22011 CBG22013 CBG22013 atm-1 atm-1 pptr-1 pptr-1 rfc-2 rfc-2 apc-2 apc-2 CBG22959 CBG22959 mdt-30 mdt-30 CBG23443 CBG23443 rad-50 rad-50 CBG23414 CBG23414 rpt-1 rpt-1 bir-1 bir-1 ndc-80 ndc-80 pptr-2 pptr-2 CBG26344 CBG26344 CBG25885 CBG25885 CBG25886 CBG25886 CBG26841 CBG26841 CBG22319 CBG22319 his-64 his-64 CBG01507 CBG01507 cki-2 cki-2 CBG20339 CBG20339 CBG24469 CBG24469 rpa-1 rpa-1 zwl-1 zwl-1 ubl-1 ubl-1 mcm-6 mcm-6 cls-2 cls-2 CBG09173 CBG09173 cls-3 cls-3 chk-1 chk-1 wee-1.3 wee-1.3 cye-1 cye-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBG23584Protein CBG23584. (252 aa)
nud-2Protein CBR-NUD-2. (281 aa)
npp-6Protein CBR-NPP-6. (1549 aa)
CBG23770Protein CBG23770. (299 aa)
CBG23920Protein CBG23920; Belongs to the AAA ATPase family. (268 aa)
rpn-11Protein CBR-RPN-11. (312 aa)
rpn-226S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (970 aa)
nud-1Protein CBR-NUD-1. (311 aa)
CBG24546Protein CBG24546. (299 aa)
rfc-4Protein CBR-RFC-4.2. (335 aa)
CBG00041Protein CBG00041; Belongs to the protein kinase superfamily. (296 aa)
emb-27Protein CBR-EMB-27. (669 aa)
zyg-9Protein CBR-ZYG-9. (1427 aa)
CBG00525Protein CBG00525; Belongs to the protein kinase superfamily. (296 aa)
CBG01828Protein CBG01828. (433 aa)
rfc-3Protein CBR-RFC-3. (354 aa)
dli-1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (441 aa)
pas-5Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (258 aa)
rmh-1Protein CBG02237. (944 aa)
CBG02222Protein CBG02222. (436 aa)
mus-101Protein CBR-MUS-101. (1175 aa)
ska-1Spindle and kinetochore-associated protein 1 homolog; Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtu [...] (239 aa)
dna-2Protein CBR-DNA-2. (1123 aa)
ebp-2Protein CBR-EBP-2. (306 aa)
orc-2Protein CBR-ORC-2. (544 aa)
mat-2Protein CBR-MAT-2. (1853 aa)
rpn-9Protein CBR-RPN-9. (382 aa)
rpn-12Protein CBR-RPN-12. (250 aa)
hpr-17Protein CBR-HPR-17. (497 aa)
wrn-1Protein CBR-WRN-1. (1061 aa)
pbs-3Proteasome subunit beta. (204 aa)
CBG03383Protein CBG03383. (567 aa)
npp-18Nucleoporin SEH1; Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus; Belongs to the WD repeat SEC13 family. (366 aa)
brc-1Protein CBR-BRC-1. (498 aa)
mcm-4DNA helicase; Belongs to the MCM family. (830 aa)
CBG03913Protein CBG03913. (215 aa)
cdc-7Protein CBR-CDC-7; Belongs to the protein kinase superfamily. (409 aa)
npp-2Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (614 aa)
hsr-9Protein CBR-HSR-9. (1165 aa)
CBG03866Protein CBG03866. (1794 aa)
icp-1Protein CBR-ICP-1. (516 aa)
rpn-5Protein CBR-RPN-5. (491 aa)
pas-1Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (246 aa)
CBG04772Protein CBG04772; Belongs to the AAA ATPase family. (426 aa)
paa-1Protein CBR-PAA-1. (606 aa)
dyci-1Protein CBR-DYCI-1. (663 aa)
dlc-5Protein CBR-DLC-5. (186 aa)
cyb-3Protein CBR-CYB-3; Belongs to the cyclin family. (386 aa)
ebp-1Protein CBR-EBP-1. (303 aa)
let-92Serine/threonine-protein phosphatase. (318 aa)
par-5Protein CBR-PAR-5; Belongs to the 14-3-3 family. (248 aa)
rpn-126S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (992 aa)
rpn-6.2Probable 26S proteasome regulatory subunit rpn-6.2; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.2 is required for proteasome assembly (By similarity); Belongs to the proteasome subunit S9 family. (411 aa)
CBG06911Protein CBG06911. (254 aa)
cya-1Protein CBG06936; Belongs to the cyclin family. (467 aa)
CBG07148Protein CBG07148. (700 aa)
CBG07147Protein CBG07147. (318 aa)
CBG07138Protein CBG07138. (178 aa)
rpt-4Protein CBR-RPT-4; Belongs to the AAA ATPase family. (398 aa)
gfi-3Protein CBR-GFI-3. (794 aa)
pbs-2Proteasome subunit beta. (277 aa)
CBG08524Protein CBG08524. (1917 aa)
CBG08884Protein CBG08884. (289 aa)
CBG08885Protein CBG08885. (257 aa)
rpt-3Protein CBR-RPT-3; Belongs to the AAA ATPase family. (417 aa)
him-10Protein CBR-HIM-10. (637 aa)
ubq-1Protein CBR-UBQ-1. (770 aa)
npp-10Protein CBR-NPP-10. (1684 aa)
evl-18Protein CBG09214. (997 aa)
pas-2Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (231 aa)
mre-11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (727 aa)
apc-10Protein CBR-APC-10. (144 aa)
pas-6Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (255 aa)
rpt-2Protein CBR-RPT-2; Belongs to the AAA ATPase family. (443 aa)
bub-1Protein CBR-BUB-1. (971 aa)
clip-1Protein CBG10142. (961 aa)
CBG10242Protein CBG10242. (358 aa)
CBG10241Protein CBG10241. (289 aa)
CBG10240Protein CBG10240; Belongs to the protein kinase superfamily. (295 aa)
CBG10664Protein CBG10664. (295 aa)
CBG10679Protein CBG10679. (409 aa)
pas-3Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (250 aa)
CBG10818Histone H2B; Belongs to the histone H2B family. (123 aa)
mat-1Protein CBR-MAT-1. (746 aa)
psmd-9Protein CBG11181. (196 aa)
bir-2Protein CBR-BIR-2. (306 aa)
mcm-3Protein CBR-MCM-3; Belongs to the MCM family. (812 aa)
rpt-6Protein CBR-RPT-6; Belongs to the AAA ATPase family. (417 aa)
hus-1Checkpoint protein; Belongs to the HUS1 family. (207 aa)
pbs-4Proteasome subunit beta. (196 aa)
CBG12075Protein CBG12075. (611 aa)
rpn-8Protein CBR-RPN-8. (382 aa)
CBG12102Protein CBG12102. (186 aa)
cdc-6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (531 aa)
ran-2Protein CBR-RAN-2. (975 aa)
npp-15Protein CBR-NPP-15. (1146 aa)
mcm-5DNA helicase; Belongs to the MCM family. (771 aa)
CBG12411Protein CBG12411. (518 aa)
pbs-7Proteasome subunit beta; Belongs to the peptidase T1B family. (251 aa)
pas-4Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (253 aa)
rpn-10Protein CBR-RPN-10. (347 aa)
rpt-5Protein CBR-RPT-5; Belongs to the AAA ATPase family. (430 aa)
mat-3Protein CBR-MAT-3. (667 aa)
san-1Protein CBR-SAN-1. (390 aa)
cki-1Protein CBR-CKI-1. (187 aa)
mcm-10Protein CBG13203. (659 aa)
mrt-2Protein CBR-MRT-2. (267 aa)
CBG13260Protein CBG13260. (251 aa)
such-1Protein CBR-SUCH-1. (769 aa)
top-3DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (774 aa)
pas-7Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (250 aa)
CBG13581Protein CBG13581. (651 aa)
pbs-1Proteasome subunit beta. (239 aa)
dlc-3Dynein light chain. (136 aa)
npp-20Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat; Belongs to the WD repeat SEC13 family. (306 aa)
mdf-2Protein CBR-MDF-2. (203 aa)
mltn-13Protein CBR-MLTN-13. (752 aa)
klp-13Protein CBR-KLP-13; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (602 aa)
CBG14893Protein CBG14893. (521 aa)
npp-7Protein CBR-NPP-7. (1226 aa)
CBG15275Protein CBG15275. (342 aa)
CBG15203Protein CBG15203. (648 aa)
ubq-2Protein CBR-UBQ-2. (128 aa)
CBG15809Protein CBG15809. (626 aa)
CBG16303Protein CBG16303. (552 aa)
rpn-6.1Protein CBR-RPN-6.1. (404 aa)
Cbr-rfc-4.1Protein CBR-RFC-4.1. (340 aa)
rod-1Protein CBR-ROD-1. (2213 aa)
mksr-2Protein CBR-MKSR-2. (175 aa)
clsp-1Protein CBG16944. (676 aa)
CBG17207Protein CBG17207. (455 aa)
ftt-2Protein CBR-FTT-2; Belongs to the 14-3-3 family. (248 aa)
czw-1Protein CBR-CZW-1. (778 aa)
cyb-1Protein CBR-CYB-1; Belongs to the cyclin family. (353 aa)
orc-5Protein CBR-ORC-5. (398 aa)
CBG17796Protein CBG17796. (53 aa)
CBG17880Protein CBG17880. (678 aa)
com-1Protein CBR-COM-1. (641 aa)
klp-7Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (743 aa)
CBG18333Protein CBG18333. (497 aa)
orc-1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (651 aa)
orc-4Protein CBR-ORC-4. (384 aa)
hpr-9Protein CBR-HPR-9. (513 aa)
mel-28Protein CBR-MEL-28. (1559 aa)
apc-11Protein CBR-APC-11. (134 aa)
CBG18037Protein CBG18037. (490 aa)
rpn-3Protein CBR-RPN-3. (506 aa)
mcm-2DNA helicase; Belongs to the MCM family. (892 aa)
kxd-1Protein CBG19105. (130 aa)
glo-4Protein CBR-GLO-4. (1392 aa)
mdf-1Protein CBR-MDF-1. (681 aa)
CBG19304Histone H2B; Belongs to the histone H2B family. (122 aa)
atl-1Protein CBR-ATL-1; Belongs to the PI3/PI4-kinase family. (2556 aa)
CBG19367Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (239 aa)
rmh-2Protein CBG19410. (602 aa)
dlc-1Dynein light chain. (89 aa)
npp-4Protein CBR-NPP-4. (515 aa)
pbs-5Protein CBR-PBS-5. (284 aa)
chk-2Protein CBR-CHK-2. (289 aa)
xpo-1Protein CBR-XPO-1. (1075 aa)
bub-3Protein CBR-BUB-3. (342 aa)
CBG20697Protein CBG20697. (173 aa)
lis-1Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. (390 aa)
exo-1Protein CBR-EXO-1. (647 aa)
CBG21459Protein CBG21459. (655 aa)
rpn-7Protein CBR-RPN-7. (409 aa)
CBG21690Protein CBG21690. (1974 aa)
pezo-1Protein CBG21689. (862 aa)
him-6Protein CBR-HIM-6. (1005 aa)
CBG21674Protein CBG21674. (171 aa)
mcm-7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (729 aa)
CBG21913Protein CBG21913. (618 aa)
wee-1.1Protein CBG21908; Belongs to the protein kinase superfamily. (419 aa)
CBG21906Protein CBG21906. (185 aa)
CBG22011Protein CBG22011. (228 aa)
CBG22013Protein CBG22013. (1122 aa)
atm-1Protein CBR-ATM-1; Belongs to the PI3/PI4-kinase family. (639 aa)
pptr-1Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (531 aa)
rfc-2Protein CBR-RFC-2. (329 aa)
apc-2Protein CBR-APC-2; Belongs to the cullin family. (700 aa)
CBG22959Serine/threonine-protein phosphatase. (551 aa)
mdt-30Protein CBR-MDT-30. (524 aa)
CBG23443Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (98 aa)
rad-50Protein CBR-RAD-50. (1354 aa)
CBG23414Protein CBG23414. (1631 aa)
rpt-1Protein CBR-RPT-1; Belongs to the AAA ATPase family. (435 aa)
bir-1Protein CBR-BIR-1. (158 aa)
ndc-80Protein CBR-NDC-80. (599 aa)
pptr-2Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (556 aa)
CBG26344Protein CBG26344. (129 aa)
CBG25885Protein CBG25885. (307 aa)
CBG25886Protein CBG25886. (111 aa)
CBG26841Protein CBG26841. (245 aa)
CBG22319Protein CBG22319. (306 aa)
his-64Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
CBG01507Histone H2B; Belongs to the histone H2B family. (122 aa)
cki-2Protein CBR-CKI-2.1. (256 aa)
CBG20339Protein CBG20339; Belongs to the AAA ATPase family. (415 aa)
CBG24469Protein CBG24469. (272 aa)
rpa-1Probable replication factor A 73 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (658 aa)
zwl-1Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores and spindle pole separation. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome segregation, the complex also inhibits the attachment of [...] (639 aa)
ubl-1Ubiquitin-like protein 1-40S ribosomal protein S27a; In the N-terminal section; belongs to the ubiquitin family. (163 aa)
mcm-6DNA replication licensing factor mcm-6; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentia [...] (810 aa)
cls-2Protein CLASP-2; Probable microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the formation of mitotic and meiotic spindles. Specifically promotes the polymerization of kinetochore-bound microtubules. Also required for cytoplasmic streaming (By similarity). (791 aa)
CBG09173Protein CLASP-1; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules; Belongs to the CLASP family. (1333 aa)
cls-3Protein CLASP-3; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules; Belongs to the CLASP family. (970 aa)
chk-1Serine/threonine-protein kinase chk-1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Required for checkpoint mediated cell cycle arrest in response to DNA damage in germline cells. Essential for embryogenesis (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. (493 aa)
wee-1.3Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase during oocyte maturation. Required for embryonic development, germline proliferation and initiation of meiosis during spermatogenesis. Required for chromosome structure during mitosis and negative regulation of nuclear envelope breakdown (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (656 aa)
cye-1G1/S-specific cyclin-E; Essential for the control of the cell cycle at the G1/S (start) transition. In association with cdk-2, regulates proliferation, quiescent state and cell fate during the development of several cell lineages. In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase. During the development of the vulva, controls the onset of vulval cell terminal differentiation by controlling the duration of G1 phase. During hypoderm development at early larval stages, controls syncytial fate of [...] (518 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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