STRINGSTRING
xpd-1 xpd-1 gtf-2h5 gtf-2h5 CBG15275 CBG15275 CBG13719 CBG13719 xpb-1 xpb-1 rpb-5 rpb-5 tlf-1 tlf-1 CBG11897 CBG11897 dcp-66 dcp-66 CBG10818 CBG10818 gtf-2h2c gtf-2h2c gtf-2h3 gtf-2h3 let-418 let-418 tbp-1 tbp-1 gcna-1 gcna-1 CBG08234 CBG08234 lin-40 lin-40 rpoa-12 rpoa-12 CBG03634 CBG03634 rpb-6 rpb-6 nra-3 nra-3 gtf-2h1 gtf-2h1 htz-1 htz-1 rpac-40 rpac-40 CBG01084 CBG01084 CBG23991 CBG23991 rpb-10 rpb-10 CBG23443 CBG23443 CBG26441 CBG26441 CBG26344 CBG26344 CBG25853 CBG25853 his-64 his-64 CBG01507 CBG01507 mbd-2 mbd-2 lin-53 lin-53 rpb-12 rpb-12 rpoa-1 rpoa-1 mnat-1 mnat-1 rpoa-2 rpoa-2 CBG19304 CBG19304 rpb-8 rpb-8 cyh-1 cyh-1 csb-1 csb-1 CBG16094 CBG16094
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
xpd-1Protein CBG15713. (755 aa)
gtf-2h5Protein CBG15257. (72 aa)
CBG15275Protein CBG15275. (342 aa)
CBG13719General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (482 aa)
xpb-1Protein CBG13269. (800 aa)
rpb-5DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower [...] (211 aa)
tlf-1Protein CBR-TLF-1. (512 aa)
CBG11897Protein CBG11897. (934 aa)
dcp-66Protein CBR-DCP-66. (748 aa)
CBG10818Histone H2B; Belongs to the histone H2B family. (123 aa)
gtf-2h2cGeneral transcription factor IIH subunit. (376 aa)
gtf-2h3Protein CBG09872. (297 aa)
let-418Protein CBR-LET-418. (1863 aa)
tbp-1Protein CBR-TBP-1. (337 aa)
gcna-1Protein CBG09024. (492 aa)
CBG08234Protein CBG08234. (2147 aa)
lin-40Protein CBR-LIN-40. (1002 aa)
rpoa-12DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (119 aa)
CBG03634Protein CBG03634. (648 aa)
rpb-6Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2; DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of t [...] (138 aa)
nra-3Protein CBR-NRA-3. (1012 aa)
gtf-2h1Protein CBG01668. (526 aa)
htz-1Histone H2A; Belongs to the histone H2A family. (142 aa)
rpac-40Protein CBG01436. (698 aa)
CBG01084Protein CBG01084. (888 aa)
CBG23991Protein CBG23991. (340 aa)
rpb-10DNA-directed RNA polymerases I, II, and III subunit RPABC5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the cor [...] (67 aa)
CBG23443Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (98 aa)
CBG26441Protein CBG26441. (111 aa)
CBG26344Protein CBG26344. (129 aa)
CBG25853Protein CBG25853. (127 aa)
his-64Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
CBG01507Histone H2B; Belongs to the histone H2B family. (122 aa)
mbd-2Methyl-binding protein-2. (210 aa)
lin-53Probable histone-binding protein lin-53; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation. Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. (416 aa)
rpb-12Protein CBR-RPB-12. (62 aa)
rpoa-1DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1764 aa)
mnat-1Protein CBR-MNAT-1. (343 aa)
rpoa-2DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1167 aa)
CBG19304Histone H2B; Belongs to the histone H2B family. (122 aa)
rpb-8Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity). (148 aa)
cyh-1Protein CBR-CYH-1. (320 aa)
csb-1Protein CBR-CSB-1. (1015 aa)
CBG16094Protein CBG16094. (251 aa)
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.